Malignant Phyllodes Tumor with Pleomorphic Liposarcomatous Stroma Diagnosed by Fine Needle Aspiration Cytology

Vera-Alvarez, J; Marigil-Gómez, Miguel; Abascal-Agorreta, Manuel; García-Prats, María Dolores; López-López, José Ignacio; Pérez-Ruiz, Javier

doi:10.1159/000326716

Cited by 12 publications

(12 citation statements)

References 15 publications

(9 reference statements)

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“…Well-documented cytology studies by FNA are limited and only small series or case reports [2][3][4][5][6][7][8][9][10][11] have been published. In an attempt to better define the fine-needle sampling (FNS) characteristics of MPT, we withdrew 22 such cases from our files whose histopathological material was available for a comparative study.…”

mentioning

confidence: 99%

Fine‐needle sampling in malignant phyllodes tumors: Clinicopathologic study of 22 cases seen at the Institut Curie

Vladescu¹,

Klijanienko²,

Caillaud³

et al. 2004

Diagnostic Cytopathology

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The preoperative cytological diagnosis of malignant phyllodes tumor (MPT) is challenging due to the heterogeneity of its clinical, radiological, and morphological presentation. To better define the cytopathological characteristics of MPT, we reviewed 22 examples seen at the Institut Curie. The original cytologic diagnosis was benign breast tumor in four cases (18.2%), suspicious in seven cases (31.8%) (low-grade phyllodes tumor in six cases needing histological evaluation, suspicious of sarcoma in one case), and malignant in 11 cases (50%). Smears were composed of different proportions of clusters of epithelial cells (68.2%), phyllodes fragments (31.8%), spindle cells within stromal tissue (31.8%), isolated spindle-shaped or round cells (45.5%), and bipolar naked nuclei (22.7%). Giant cells and mitotic figures were also occasionally seen. The cytological findings on smears were correlated with histopathological observations. One of the difficulties to reach an accurate cytological diagnosis for MPT is the frequent overwhelming of clearly malignant sarcomatous cell by the presence of largely predominant clusters of epithelial cell.

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confidence: 99%

Fine‐needle sampling in malignant phyllodes tumors: Clinicopathologic study of 22 cases seen at the Institut Curie

Vladescu¹,

Klijanienko²,

Caillaud³

et al. 2004

Diagnostic Cytopathology

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“…[12] Malignant phyllodes tumors are rare ones comprising 0.18% of all breast malignancies. [3] They occur most often in 30–70 year-old females, the median age at the time of diagnosis being 45 years with a few occurring in adolescents.…”

Section: Discussionmentioning

confidence: 99%

“…[8] The neoplastic stromal components is highly pleomorphic reminiscent of fibrosarcoma, malignant fibrous histiocytoma, rhabdomyosarcoma liposarcoma, and osteogenic sarcoma. [1910] Osseous differentiation of the stroma contributes to the histologic complexity of these tumors and correlate with malignant phyllodes tumor (high grade).…”

Section: Discussionmentioning

confidence: 99%

“…A small percentage of tumors are histologically overtly malignant, constituting less than ten percent of all phyllodes tumors. [1] Osseous differentiation is an extremely rare stromal alteration in phyllodes tumor causing histologic complexity. Preoperative diagnosis of these tumors by fine needle aspiration cytology (FNAC) and identification of overtly malignant tumor can help in planning the extent of surgery.…”

Section: Introductionmentioning

confidence: 99%

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Osseous differentiation in cystosarcoma phyllodes - diagnosed by fine needle aspiration cytology

Krishnamurthy

2010

J Cytol

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Osseous differentiation within a phyllodes tumor is extremely rare. Cytological and histological findings of a case of malignant phyllodes tumor with osseous differentiation are presented. A 45-year-old female had a malignant phyllodes tumor with osseous stroma diagnosed by fine needle aspiration cytology. The cytological findings were representative of the histological features. The diagnosis of these tumors preoperatively is important in planning the most appropriate treatment. It is also important to follow up these patients postoperatively for long periods for recurrence and metastasis.

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“…It may be a component of malignant phyllodes tumour. 99,111 Rare cases have been reported arising as radiation-induced sarcomas. 112 A range of morphologies may be encountered, including spindled, pleomorphic or epithelioid; however, the defining feature is the presence of often bizarre-appearing pleomorphic lipoblasts.…”

Section: Pleomorphic Liposarcomamentioning

confidence: 99%

Mesenchymal tumours of the breast and their mimics: a review with approach to diagnosis

2016

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Malignant Phyllodes Tumor with Pleomorphic Liposarcomatous Stroma Diagnosed by Fine Needle Aspiration Cytology

Cited by 12 publications

References 15 publications

Fine‐needle sampling in malignant phyllodes tumors: Clinicopathologic study of 22 cases seen at the Institut Curie

Fine‐needle sampling in malignant phyllodes tumors: Clinicopathologic study of 22 cases seen at the Institut Curie

Osseous differentiation in cystosarcoma phyllodes - diagnosed by fine needle aspiration cytology

Mesenchymal tumours of the breast and their mimics: a review with approach to diagnosis

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