Malignant phyllodes tumor with heterologous liposarcomatous differentiation and tubular adenoma-like epithelial component

Abstract

Phyllodes tumor of the breast is a biphasic fibroepithelial neoplasm. A 30-year-old woman presented with a 1-year history of a palpable, asymptomatic right breast mass without axillary lymphadenopathy and family history of breast carcinoma. Malignant phyllodes tumor was diagnosed. The authors present not previously described histological appearance of this tumor where an epithelial component was identical to that of a tubular adenoma of the breast, with the review of the literature. This is in addition to very rare liposarcomatous stromal differentiation in the malignant phyllodes tumor.

Chromosomal aberrations and genetic relations in benign, borderline and malignant phyllodes tumors of the breast: a comparative genomic hybridization study

“…Histologically, PTs are classified as benign, borderline, or malignant on the basis of stromal cellularity, nuclear atypia, mitotic activity, stromal distribution, and margin appearance (infiltrating or pushing) (see Fig. 1a-c) [6][7][8][9][10]. In view of the progression to sarcoma in some cases, the stroma of PTs is generally thought to be the neoplastic element.…”

Malignant phyllodes tumor of the breast with liposarcomatous differentiation and intraductal hyperplasia

“…Malignant epithelial transformation is uncommon [6,7]. The most common alterations in the epithelial element of phyllodes tumor are focal apocrine change or squamous metaplasia, areas of adenosis, and cystic changes [8,9]. All authors agree that the treatment for sarcoma of the breast should be early and complete surgical excision of the mass.…”

“…All recurrent tumors reported were pleomorphic in type and all had invasive margins. The role of chemotherapy and radiotherapy is still uncertain [8]. Complete excision with tumor-free margins is essential; mastectomy is not necessary provided excision margins are tumor free [5].…”

Malignant Phyllodes Tumor Mimicking Metaplastic Carcinoma of Breast- A Case Report

“…[9] These tumors with heterologous differentiation of osteosarcoma and chondrosarcoma are rare, accounting for 1.3% of all phyllodes tumors. [10,11,12] In the population of Asian women, the incidence of phyllodes is 6.92%, as compared to the western population, where the quoted incidence is 0.3 to 1.5% [13] . Tumors of the breast showing bone and cartilage differentiation are: Intraductal papilloma with stromal metaplasia, cystosarcoma phyllodes, stromal sarcoma, and adenocarcinoma with metaplasia [14] .…”