Malignant phyllodes tumor of the breast with lymph node metastasis shown by FDG PET-CT

Chinchilla, A. Santiago; Font, C. Ramos; Aguirre, A.C. Rebollo; Laínez, Martínez; Gerona, H. Palacios; Elvira, J.M. Llamas

doi:10.1016/s1578-200x(10)70045-0

Cited by 5 publications

(5 citation statements)

References 3 publications

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“…Cystic change may be seen as well. A rapid enhancement pattern is seen more commonly with benign rather than with malignant phyllodes tumors, which is the opposite of the pattern seen with adenocarcinomas of the breast [54-57]. 18 F-FDG PET/CT therefore is useful in imaging recurrent phyllodes tumors, since it can display rare unsuspected sites of metastasis [57].…”

Section: Discussionmentioning

confidence: 99%

Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature

et al. 2021

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Phyllodes tumor of the breast is an infrequently encountered fibroepithelial neoplasm, which accounts for 0.3–1% of all tumors. Few case reports have described the occurrence of giant phyllodes tumor. To our knowledge, about 20% of phyllodes tumors would be considered giant benign. Complete surgical excision is the standard of care for giant benign phyllodes tumors; axillary lymph node metastasis is rare, and dissection should be limited to patients with pathologic evidence of tumor in the lymph nodes. We report the case of a 40-year-old Mexican woman with giant mammary tumor who underwent a right total mastectomy. The pathology results showed a benign phyllodes tumor 4,857 g in weight and 40.2 × 36.3 × 15 cm in size. We do not suggest adjuvant radiation therapy for patients with benign phyllodes tumors that are widely excised. A review of the pertinent literature was performed.

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Section: Discussionmentioning

confidence: 99%

Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature

et al. 2021

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“…Addition of radiotherapy did not affect DFS. Although there have been no randomized clinical trials on the role of systemic therapy in malignant PTs, various chemotherapy regimens containing doxorubicin, dacarbazine, cisplatin, isophosphamide, and etoposide are generally recommended for patients with malignant and/or metastatic disease [28]. Nevertheless, adjuvant chemotherapy was reported to have no beneficial effect on patient survival [20].…”

Section: Discussionmentioning

confidence: 99%

Phyllodes Tumors of the Breast (the Egyptian Experience)

Ibreaheem

Naguib

Gamal

et al. 2020

Indian J Surg Oncol

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Phyllodes tumors (PT) are rare fibroepithelial lesions, about 0.3-0.5% of all breast tumors. This study is an evaluation of patient characteristics, clinicopathologic features, diagnostic tools, therapeutic options, risk factors for recurrence, and distant metastasis and follow-up findings in patients with PTs. One hundred twenty-seven patients with pathologically proved PTs in the National Cancer Institute, Cairo University, Egypt, from January 2011 to January 2016 were reviewed and analyzed. Sixty patients presented with benign PTs (47.2%), 34 had borderline PTs (26.8%), and 33 had malignant PTs (26%). The mean follow-up period was approximately 36 months; local recurrence occurred in 34 patients, 9 benign cases (14.5%), 11 borderlines (32.4%), and 14 malignant PTs (42.4%). Mastectomy was the most commonly used surgery in recurrent cases (61.4%). Axillary staging was performed in 31 cases (24.4%); only 2 cases showed positive nodal metastasis (6.5%) and were of the malignant subtype. Distant metastasis occurred in 12 patients, 4 with borderline PTs, and 8 with malignant PTs. The most common site for metastasis was the lungs and bones. Adjuvant radiotherapy was applied in 9 patients, 2 in borderline phyllodes, and 7 in malignant phyllodes; post-radiotherapy recurrence occurred in 5 malignant phyllodes patients. Chemotherapy was employed in 10 metastatic patients (4 with borderline and 6 with malignant phyllodes); excision with clear margins is important to reduce the local recurrence. Routine axillary staging should not be done. The adjuvant radiation therapy is still controversial. Local recurrence can develop even after appropriate surgery. Therefore, close follow-up is mandatory.

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“…4,12,23,24 Even though PET/CT imaging has been widely studied in lymphomas and in breast cancer, there is a lack of literature about the role of PET/CT in the diagnosis of phyllodes tumors, because of the rarity of this disease. [25][26][27][28] In 1996, Holle et al first showed an intense 18 F-FDG uptake in a rapidly growing phyllodes tumor. 29 Two years later, Bakheet and colleagues reported the case of a 22-year-old woman with an 18 F-FDG avid focus in the right breast corresponding to the local recurrence of a cystosarcoma phyllodes.…”

Section: Discussionmentioning

confidence: 99%

A Strange Case of Phyllodes Tumor Detected Using 18F-FDG PET/CT in an Adolescent Patient Affected by Hodgkin Lymphoma: A Possible Pitfall

Cucinotta

Quartuccio

Coppolino

et al. 2014

Clinical Lymphoma Myeloma and Leukemia

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Malignant phyllodes tumor of the breast with lymph node metastasis shown by FDG PET-CT

Cited by 5 publications

References 3 publications

Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature

Giant Benign Mammary Phyllodes Tumor: Report of a Case and Review of the Literature

Phyllodes Tumors of the Breast (the Egyptian Experience)

A Strange Case of Phyllodes Tumor Detected Using 18F-FDG PET/CT in an Adolescent Patient Affected by Hodgkin Lymphoma: A Possible Pitfall

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