Malignant peripheral nerve sheath tumours in the head and neck region: retrospective analysis of clinicopathological features and treatment outcomes

Ma, ChengHua; Ow, Andrew; Shan, O.H.; Wu, Yiqun; Zhang, Chi; Sun, Jian; Ji, Tong; Martín, Lorena Pingarrón; Wang, L.

doi:10.1016/j.ijom.2014.03.006

Cited by 26 publications

(56 citation statements)

References 25 publications

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“…Patients with S-100 protein negative had a higher recurrence rate and a poorer survival rate as compared with those with S-100 positive. The NF-1 status and tumor size were considered prognostic factors for overall survival in previous research [6,11,12,14,16,17]. But NF-1 was detected in only 6 patients in our series, which was not an independence prognostic factor for both recurrence and overall survival.…”

Section: Discussioncontrasting

confidence: 66%

“…MPNSTs are rare tumors with poor prognosis [8,11,12,16,22,23]. There is limited information in the literature regarding prognostic factors and long-term outcomes of MPNSTs due to rarity.…”

Section: Discussionmentioning

confidence: 99%

“…The possible reason might be that osteolytic destruction is more common in patients with high grade MPNST and meanwhile it may increase the difficulty of surgical treatment. Surgical resection is the foundational treatment strategy for MPNSTs [8,11,12,14,16,17,23]. Many authors confirmed that total resection with a clear margin could reduce the recurrence rate and improve the prognosis of MPNST [11,12,17,23].…”

Section: Discussionmentioning

confidence: 99%

“…Surgical resection is the foundational treatment strategy for spinal MPNST, although chemotherapy and radiotherapy have also been reported in the literature [6,[10][11][12]. However, total surgical resection of spinal MPNSTs is sometimes difficult due to the complexity of the spine structure [8].…”

Section: Introductionmentioning

confidence: 99%

“…So, local recurrence and death are not uncommon in spinal MPNST. The reported recurrence rate is 29-51 % [11,12,14], and the 5-year survival rate is 30-50 % [15]. Some prognostic factors of MPNSTs have been reported, including tumor size, malignant grade, surgery type and radiotherapy [6,11,16].…”

Section: Introductionmentioning

confidence: 99%

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Malignant peripheral nerve sheath tumor (MPNST) in the spine: a retrospective analysis of clinical and molecular prognostic factors

et al. 2015

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Spinal malignant peripheral nerve sheath tumors (MPNSTs) are relatively rare. There is little information published in the literature regarding this subject. The aim of this retrospective study was to evaluate factors that may affect the outcomes of patients with spinal MPNSTs by reviewing 43 patients with spinal MPNST who were treated in our hospital between 2001 and 2012. Univariate and multivariate analyses were performed to identify prognostic variables relative to patient and tumor characteristics, treatment modality and molecules. All 43 MPNST patients (25 men and 18 women; median age 49 years) underwent surgical resection, of whom 15 patients also underwent postoperative radiotherapy. Local recurrence was found in 21 (48.8 %) patients. Twenty-two (51.2 %) patients died during the follow-up periods with a median survival time of 49 months. The 5-year recurrence and survival rate was 53 and 44 % respectively. The statistical analyses suggested that high-grade malignancy and osteolytic destruction were closely associated with recurrence and death. A total of 38 cases accepted postoperative immunohistochemisty examine. S-100 was identified as an independent factor related to both recurrence and survival, adjusting for clinical factors. In conclusion, we confirmed that malignant grade and osteolytic destruction were the two independent factors for both recurrence and survival, while patients with S-100 protein negative had a higher recurrence rate and a lower survival rate.

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Section: Discussioncontrasting

confidence: 66%

“…MPNSTs are rare tumors with poor prognosis [8,11,12,16,22,23]. There is limited information in the literature regarding prognostic factors and long-term outcomes of MPNSTs due to rarity.…”

Section: Discussionmentioning

confidence: 99%