Malignant Peripheral Nerve Sheath Tumour (Malignant Schwannoma) in the Diaphragm of a Goat

Ramı́rez, G.A.; Herráez, P.; Rodríguez, Fausto J.; Godhino, A.; Andrada, M.; Monteros, A. Espinosa de los

doi:10.1016/j.jcpa.2007.05.003

Cited by 24 publications

(33 citation statements)

References 8 publications

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“…[3][4][5][7][8][9]11,13,15 The tumors are broadly classified as benign or malignant based on cell morphology and invasiveness. 6,9,11 Histologically, PNSTs contain 2 characteristic patterns: dense sheets and fascicles of spindle cells with fusiform nuclei (Antoni A areas) and other regions of loosely arranged spindle cells with smaller, round, dark nuclei that are separated by a mucinous matrix (Antoni B areas). [3][4][5][6][7][8]11,14,15 Verocay bodies are occasionally found within Antoni A areas and are characterized by 2 chains of nuclei arranged at the margins of a central cytoplasmic zone.…”

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Malignant peripheral nerve sheath tumor in a cat with nodal and pulmonary metastases

et al. 2012

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Abstract. Peripheral nerve sheath tumors in domestic cats are infrequently reported and are often locally invasive. An 11-year-old Domestic Shorthair cat was originally diagnosed with a right maxillary benign peripheral nerve sheath tumor at incisional biopsy. At necropsy, the neoplasm had features of malignancy including metastases to the regional lymph nodes and lung. Histologically, the neoplasm contained 2 distinct regions: spindle cells arranged in dense interwoven bundles with Antoni A areas and Verocay bodies and Antoni B regions with loosely arranged spindle cells separated by a mucinous matrix. Immunohistochemically, the neoplastic cells in the primary mass and right mandibular lymph node were strongly positive for vimentin, S-100, and glial fibrillar acidic protein. The neoplastic cells within the lung were strongly positive for vimentin and weakly positive for S-100 and glial fibrillar acidic protein.

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“…4,6,11,13,15 Malignant peripheral nerve sheath tumors (MPNSTs) are typically locally recurrent but rarely metastasize 4,5,11,13 ; however, case reports of metastases in a cow, 8 goats, 7,9 and dogs 3,14 have been published. There is 1 documented case of a MPNST in a Siberian tiger that metastasized to mediastinal lymph nodes and lung.…”

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Malignant peripheral nerve sheath tumor in a cat with nodal and pulmonary metastases

et al. 2012

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“…Similar representations such as epitheliod type [10], cartilaginous and osteogenic [1], glandular epithelial differentiation [20] or their complexes [12] have been found in canine MPNSTs. Furthermore, cases of atypical cell morphology such as tumor cells with eosinophilic cytoplasmic globules have also occurred in dogs and one goat [6,15,21]. Our report describes a canine MPNST with cytoplasmic globules arising from the greater omentum.…”

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confidence: 71%

“…Human MPNSTs occasionally show histologic evidence of focally divergent differentiation to rhabdomyosarcoma, osteosarcoma, chondrosarcoma, angiosarcoma, epithelial elements, or a combination thereof [9,24] [6,15,21]. Our report describes a canine MPNST with cytoplasmic globules arising from the greater omentum.…”

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Primary Malignant Peripheral Nerve Sheath Tumor with Eosinophilic Cytoplasmic Globules Arising from the Greater Omentum in a Dog

Sugiyama

Morita

Shimada

et al. 2008

The Journal of Veterinary Medical Science

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ABSTRACT. A 10-year-old Golden Retriever dog had a solitary tumor mass arising from the greater omentum. Histologically, the tumor showed varying cellularity and patterns of cellular arrangement. In dense cellular areas, spindle-shaped cells were arranged in interlacing bundles. The sparse cellular area was characterized by loosely arranged fusiform cells. The neoplastic cells frequently contained PASpositive eosinophilic globules in the cytoplasm, and mitotic figures were frequently observed. The tumor cells were positive to vimentin, S-100 protein, glial fibrillary acidic protein, myelin basic protein, neuron-specific enolase and myoglobin. The present tumor was diagnosed as a malignant peripheral nerve sheath tumor (MPNST) with eosinophilic cytoplasmic globules arising from the greater omentum. To our knowledge, this may be the first case of primary omental MPNST in domestic animals. KEY WORDS: canine, greater omentum, malignant peripheral nerve sheath tumor.J. Vet. Med. Sci. 70 (7): [739][740][741][742] 2008 Primary omental tumors are extremely rare in animals. A search of the literature in English over the past 20 years revealed no reports of only two tumors (lipoma and liposarcoma) in 2 dogs [3,8]. Moreover, only a few cases of a primary tumor of the peripheral nerves arising from the greater omentum have been reported in humans [2,11], but none in domestic animals.Malignant tumors arising from peripheral nerves or displaying differentiation along the lines of the various elements of the nerve sheath are collectively referred to as malignant peripheral nerve sheath tumors (MPNSTs) [24]. Human MPNSTs occasionally show histologic evidence of focally divergent differentiation to rhabdomyosarcoma, osteosarcoma, chondrosarcoma, angiosarcoma, epithelial elements, or a combination thereof [9,24] [6,15,21]. Our report describes a canine MPNST with cytoplasmic globules arising from the greater omentum.A 10-year-old neutered-male Golden Retriever was referred with a 1-week history of anorexia without vomiting or diarrhea. Ultrasonography showed a large, solitary, welldefined and extrahepatic mass close to the liver with a smooth surface and non-homogeneous echo levels. Computed tomography (CT) detected a large mass in the left upper abdomen (Fig. 1).The mass was surgically resected and, upon gross examination, was found to have arisen from the greater omentum and to reveal a smooth, dark whitish red surface with edematous areas (Fig. 2). The mass measured 17 × 11 × 8 cm in diameter and weighed 1,500 g. The cut surface showed solid tissue with hemorrhaging, necrosis and multiple cysts containing a dark red fluid. The tumor did not invade or adhere to other organs, and no metastasis or ascites was observed.The resected tissue was fixed in 10% formalin and embedded in paraffin wax. Sections were cut at 5 µm and stained with haematoxylin and eosin (HE) and periodic acid-Schiff (PAS) with or without diastase digestion. For

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“…However, diffuse neurofibroma must be distinguished from malignant PNST. In animals, PNSTs are most often reported in dogs and cattle (Bundza et al 1986;Johnson et al 1988;Summers et al 1995;Zachary 2007), infrequently in cats and horses (Goldschmidt & Hendrick 2002;Quinn et al 2005;Sturgeon et al 2008), and rarely in other species, such as goats (Veazey et al 1993;Ramirez et al 2007), pigs (Tanimoto & Ohtsuki 1993), birds (Bossart 1983;Ono et al 2004), and fish (Marino et al 2008, Marino et al 2010. In veterinary medicine, many authors have so far considered schwannoma and neurofibroma as a unique entity, suggesting they be named together with the general term of peripheral nerve sheath tumor (PNST), both benign and malignant (MPNST), because of the presence of a mixed cell population and/or lack of cellular differentiation on histopathology.…”

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Peripheral nerve sheath tumor invading the nasal cavities of a 6-year-old female Pointer dog

Sfacteria

Perillo

Macrı̀

et al. 2015

Veterinary Quarterly

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Malignant Peripheral Nerve Sheath Tumour (Malignant Schwannoma) in the Diaphragm of a Goat

Cited by 24 publications

References 8 publications

Malignant peripheral nerve sheath tumor in a cat with nodal and pulmonary metastases

Malignant peripheral nerve sheath tumor in a cat with nodal and pulmonary metastases

Primary Malignant Peripheral Nerve Sheath Tumor with Eosinophilic Cytoplasmic Globules Arising from the Greater Omentum in a Dog

Peripheral nerve sheath tumor invading the nasal cavities of a 6-year-old female Pointer dog

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