Malignant peripheral nerve sheath tumor arising from the greater omentum: Case report

Abstract

Malignant peripheral nerve sheath tumors (MPNSTs) are rare soft tissue tumors that arise from a peripheral nerve or exhibit nerve sheath differentiation. Most of these tumors arise on the trunk, extremities, or head and neck regions; they are very rarely located in the abdominal cavity. The patient was a 71-year-old man who was referred to our hospital for a mass and pain in the right lower abdomen. Abdominal computed tomography revealed a large (9 × 9 cm), well-circumscribed, lobulated, heterogeneously enhanced mass in the pelvis. Exploratory laparotomy revealed a large mass in the greater omentum, and the tumor was completely excised. Histopathological analysis revealed that the tumor was composed of spindle cells with high mitotic activity. On staining the tumor, positive results were obtained for S-100 but negative results were obtained for c-kit, cluster of differentiation (CD)34, α-smooth muscle actin, and desmin. These findings strongly supported a diagnosis of MPNST primarily arising from the greater omentum. To the best of our knowledge, this is the first reported case of an MPNST arising from the greater omentum. In this report, we have described the case of a patient with an MPNST arising from the greater omentum and have discussed the clinical characteristics and management of MPNSTs.

Malignant Solitary Fibrous Tumor with Heterologous Rhabdomyosarcomatous Differentiation: A Case Report

“…MPNST has features of heterogeneous spindle cells with variable growth pattern and arrangement and has bizarre giant cells, high mitotic activities, and distinguishing patterns of necrosis [10]. MPNST also shows focal immunopositivity for S100 protein.…”

Malignant Peripheral Nerve Sheath Tumor of the Small Bowel: An Unusual Presentation with Fatal Outcome

“…So, current recommendations may be based only on what is known for this tumor in other locations of the body [3]. …”

“…Most case series indicate limited benefits and high morbidity of using adjuvant radiotherapy or chemotherapy. These treatments should be reserved for cases of positive margins, recurrent disease, or when wide local excision is unfeasible [2, 3]. …”

“…Malignant peripheral nerve sheath tumors arising from the gastrointestinal tract are extremely rare, with a few cases being reported in the literature for the small bowel [2, 3]. Because the clinical symptoms in this localization are usually nonspecific, the diagnostic is often late and makes wide excision more difficult.…”

Extrathoracic malignant peripheral nerve sheath tumor of the lateral chest wall locally recurred and metastasized to peritoneum: Report of a case

“…In the case we presented, the patient experienced a local recurrence twice and had multiple metastases; one was resected from the right lung and one large tumor from the abdomen. Although MPNSTs arising from the greater omentum have been reported in the literature, 6 its metastasis to the peritoneum is very uncommon. The prognosis of patients with this tumor is poor 1 .…”