Malignant pericardial effusion as initial solitary site of metastasis from transitional cell carcinoma of the bladder

Fabozzi, Scott J.; Newton, Joseph; Moriarty, Richard P.; Schellhammer, Paul F.

doi:10.1016/0090-4295(95)80025-5

Cited by 25 publications

(29 citation statements)

References 13 publications

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“…In the other case, the cytodiagnosis suggested malignancy. 4,5,7 In our case, symptoms were similar to previously reported cases. Plain chest radiography showed a "water bottle" heart, and echocardiography was useful to evaluate pericardial effusion.…”

Section: Discussionsupporting

confidence: 79%

“…2 In the case of UC, 10% of autopsied cases show cardiac metastases. 4 Pericardial effusions were found in 25.4% of those with cardiac involvement. However, cases presented as clinically significant cardiac tamponade are rare.…”

Section: Discussionmentioning

confidence: 99%

“…Including the present case, 14 cases of symptomatic cardiac metastases from UC have been reported so far: 7 bladder cancers and 7 renal pelvic cancers. [4][5][6][7][8][9][10][11][12][13][14][15][16] (Table-1). There have been 3 reported cases of cardiac tamponade from urothelial carcinoma.…”

Section: Discussionmentioning

confidence: 99%

“…There have been 3 reported cases of cardiac tamponade from urothelial carcinoma. 4,5,7 In all the cases, symptoms included dyspnea, fatigue, orthopnea and chest pain. Plain chest radiography revealed an enlarged cardiac silhouette or "water bottle" heart.…”

Section: Discussionmentioning

confidence: 99%

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Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Hattori

Miyajima

Maeda

et al. 2012

CUAJ

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A 53-year-old man presented for further evaluation due to microscopic hematuria and left lumbar pain. Computed tomography revealed a large tumour in the left renal pelvis with multiple metastases. Despite effective systemic chemotherapy, he developed dyspnea, and was diagnosed with cardiac tamponade. Pericardial involvement in an advanced malignancy is common, but symptomatic cardiac metastasis from urothelial carcinoma is rare. Of the reports of symptomatic cardiac metastasis from urothelial carcinoma, only 3 cases presented as cardiac tamponade. We report here a rare case of cardiac tamponade caused by a renal pelvic carcinoma with positive cytodiagnosis of pericardial effusion. We also summarize and discuss the symptoms, treatment, and prognosis of the pathological condition, and present a brief review of previously published reports.

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Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Hattori

Miyajima

Maeda

et al. 2012

CUAJ

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“…Other tumours producing metastasis to skeletal muscle include osteogenic sarcoma [2,3], melanoma [4], adenocarcinoma of colon [5], stomach [6], ovary [7], leiomyosarcoma [8], mesothelioma [9] and nasopharyngeal carcinomas [10]. Metastasis from transitional cell carcinoma to brain [11], skin [12] and pericardial effusion [13] are also described. Skeletal muscle metastasis from transitional cell carcinoma of bladder has been reported only by Nabi et al [14].…”

Section: Discussionmentioning

confidence: 99%

Multiple Skeletal Muscle Metastases in a Case of Transitional Cell Carcinoma of Bladder Detected by F-18 FDG PET/CT

Kashyap

Mittal

Chakraborty

et al. 2010

Nucl Med Mol Imaging

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Cytomorphologic features of metastatic urothelial carcinoma in serous effusions

Huang

Attele

Michael

2012

Diagnostic Cytopathology

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Metastatic urothelial carcinoma (UC) to serous effusion (SE) is extremely rare and its cytomorphological features have only been described in case reports. In this study, we searched the pathology database at University of Michigan for SEs due to metastatic UC in the last 20 years. A total of 25 cases from 20 patients with clinically and pathologically confirmed metastatic UC in SEs were retrieved. The specimens consisted of 15 pleural, 8 peritoneal, and 2 pericardial effusions. Smears were reviewed and evaluated for the following features: cellularity, single cells, cell clusters or short cords, cell wrapping, "windows" between the cells, two-tone cytoplasm, cytoplasmic vacuoles, signet ring cells, nuclear to cytoplasmic (N/C) ratio, nuclear hyperchromasia, irregular nuclear membrane, nuclear centricity, double or multiple nuclei, nucleoli, anaplastic cells and mitosis. Our results showed that UC manifested in SEs predominantly as a single cell population with or without clusters or short cords, and frequently exhibited the "cell wrapping" of two or more cells. Individual UC cell in SEs exhibited nuclear enlargement with increased N/C ratio, irregular nuclear membranes, hyperchromatic coarse chromatin and frequently prominent nucleoli. Double or multinucleated cells, cells with vacuolated cytoplasm or signet ring appearance were also frequently present. Our results demonstrated that while certain features could suggest the diagnosis of UC, the cytomorphological features are not specific and often overlap with those of reactive mesothelium, mesothelioma, metastatic adenocarcinoma, or squamous cell carcinoma in SEs. Accurate diagnosis of UC rests on the combination of clinical history, cytomorphologic features and appropriate immunohistochemical panel.

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Malignant pericardial effusion as initial solitary site of metastasis from transitional cell carcinoma of the bladder

Cited by 25 publications

References 13 publications

Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Metastatic urothelial carcinoma to pericardia manifested by dyspnea from cardiac tamponade during systemic chemotherapy: case report and literature review

Multiple Skeletal Muscle Metastases in a Case of Transitional Cell Carcinoma of Bladder Detected by F-18 FDG PET/CT

Cytomorphologic features of metastatic urothelial carcinoma in serous effusions

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