MALIGNANT PARAGANGLIOMA IN A COUGAR (<i>PUMA CONCOLOR</i>)

Duhamelle, Alexis; Langlois, Isabelle; Pey, Pascaline; Tremblay, Josée; Ruel, H; Parent, J; Lussier, J. J.; Doré, Monique

doi:10.1638/2014-0051.1

Cited by 3 publications

(11 citation statements)

References 12 publications

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“…15 Rich capillary network and subsequent intense postcontrast attenuation are also described in humans 23,25 and leopard. 11 Heterogeneity of the parenchyma is also a common finding in retroperitoneal paragangliomas in people as cystic changes, necrosis, hemorrhage, and mineralization are frequent. 1,23,25 The included MRI showed an amorphous heterogeneous mass.…”

Section: Discussionmentioning

confidence: 99%

“…Such a consequence has been described before. 10,11 Due to the paucity of published studies in veterinary medicine about retroperitoneal paragangliomas and as they can be very small, and located in a similar anatomic region, these masses were quite often (5/9) mistaken in imaging reports for enlarged renal or lumbo-aortic lymph nodes. In two cases, each with a mass localized around the renal artery, dogs were referred for an adrenal nodule, confusion supposedly due to their close locations.…”

Section: Discussionmentioning

confidence: 99%

“…13,14 Similarly, splenic and hepatic metastases were found in leopard. 11 Nuclear imaging could identify metastases, as described in people. 23,25 In two case reports of canine pheochromocytoma, the authors identified pheochromocytoma or metastasis using nuclear medicine.…”

Section: Discussionmentioning

confidence: 99%

“…They may also cause a mass effect resulting in compromise of adjacent organs. Paragangliomas have been reported to cause ureteral obstruction in a cat, 10 urinoma in a cougar, 11 and spinal cord compression in a dog 12 . If these neoplasms are functional, excess of catecholamines will create similar nonspecific, episodic clinical signs observed with pheochromocytomas 4,5 …”

Section: Introductionmentioning

confidence: 99%

“…Apart from descriptions in human beings, [23][24][25][26] this localization and type of neoplasm has only been described ultrasonographically in two cats 10,27 and on CT study in a cougar. 11 In humans, CT examination is the preferred modality partly for its excellent spatial resolution. 28 The goal of this study was to describe the imaging features of confirmed retroperitoneal paragangliomas in a group of dogs and their topography relative to AGs and adjacent vessels.…”

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confidence: 99%

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Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Gombert

Diana

Hecht

et al. 2022

Vet Radiology Ultrasound

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Retroperitoneal paragangliomas are rare tumors of the neuroendocrine system. Only a few canine case reports are available with rare descriptions of their imaging features.The objectives of this multi-center, retrospective case series study were to describe the diagnostic imaging features of confirmed retroperitoneal paragangliomas and specify their location. Medical records and imaging studies of 10 affected dogs with cytological or histopathologic results concordant with retroperitoneal paragangliomas were evaluated. Dogs had a median age of 9 years. Four of them had clinical signs and laboratory reports compatible with excessive production of catecholamines. Six ultrasound, four CT, four radiographic, and one MRI studies were included. The paragangliomas did not have a specific location along the aorta. They were of various sizes (median 33 mm, range: 9-85 mm of length). Masses had heterogeneous parenchyma in six of 10 dogs, regardless of the imaging modality. Strong contrast enhancement was found in all CT studies. Encircling of at least one vessel was detected in six of 10 masses, clear invasion of a vessel was identified in one of 10 masses. In five of 10 cases, the masses were initially misconstrued as lymph nodes by the on-site radiologist. Retroperitoneal paragangliomas appear along the abdominal aorta, often presenting heterogeneous parenchyma, possibly affecting the local vasculature, and displaying strong contrast enhancement on CT. Clinical signs can be secondary to mass effects or excessive catecholamine production. Underdiagnosis and misdiagnosis of this tumor are suspected as they can be silent, of small size, or confused with other structures.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Gombert

Diana

Hecht

et al. 2022

Vet Radiology Ultrasound

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Concurrent extra‐adrenal paraganglioma and uterine leiomyosarcoma in a degu (Octodon degus)

Payne

Munns²,

Urresti³

et al. 2022

Vet Record Case Reports

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An adult, female degu (Octodon degus) presented with a single, firm, nodular, 8 × 8 × 10 mm, fast‐growing mass located between the cranial thoracic vertebrae and the cranial aspect of the right scapula. Cytology, histopathology and immunohistochemistry confirmed an extra‐adrenal paraganglioma (chromogranin A, neuron‐specific enolase and S100 positive, and cytokeratin AE1/3 negative) within the deep adipose tissue underlying the panniculus muscle. Complete surgical excision was achieved; however, within 1 month after surgery, a novel fast‐growing intra‐abdominal mass was detected. The animal was subsequently euthanased. Postmortem examination only revealed a single, well‐demarcated, spherical, firm, 40 × 40 × 42 mm tumour arising from within the left uterine horn. Histology and immunohistochemistry confirmed a uterine leiomyosarcoma (smooth muscle actin positive). This case report represents the first case of an extra‐adrenal paraganglioma and the second case of a uterine‐specific leiomyosarcoma in this species.

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Subcutaneous ureteral bypass for treatment of bilateral ureteral obstruction in a cat with retroperitoneal paraganglioma

Borchert¹,

Berent²,

Weisse³

2018

javma

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CASE DESCRIPTION A 7-year-old female domestic shorthair cat was referred for evaluation of azotemia and unilateral hydronephrosis. CLINICAL FINDINGS Abdominal ultrasonography revealed right-sided hydronephrosis and dilation of the proximal aspect of the ureter; the left kidney was small with irregular margins. A highly vascular, irregular retroperitoneal mass, not clearly associated with the ureteral obstruction, was also visualized. Surgical exploration confirmed a retroperitoneal mass involving the caudal mesenteric artery and both ureters, with hydroureter on the right side. TREATMENT AND OUTCOME A subcutaneous ureteral bypass (SUB) device was surgically implanted to treat right ureteral obstruction, and the mass was biopsied. Shortly after surgery, progressive azotemia and hyperkalemia were detected; ultrasonographic examination revealed left-sided hydronephrosis and hydroureter, which was suspected secondary to inflammation of the mass causing a left-sided ureteral obstruction. A second surgery was performed to place an SUB device for the left kidney and remove the retroperitoneal mass; both ureters were ligated at the mid- and distal aspects and then transected and removed with the mass. A neuroendocrine paraganglioma was identified by histopathologic evaluation of the mass. Hydronephrosis improved (right kidney) or resolved (left kidney) after surgery, and azotemia improved. Chemotherapeutic intervention was declined. Markers of renal function were static during the 14-month follow-up period. At the last follow-up evaluation, the patient was reportedly doing well, and both SUB devices were patent. CLINICAL RELEVANCE This was the first report of retroperitoneal paraganglioma in a domestic cat causing bilateral ureteral obstruction. Bilateral SUB device placement enabled en bloc mass resection and provided long-term relief of ureteral obstruction.

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MALIGNANT PARAGANGLIOMA IN A COUGAR (PUMA CONCOLOR)

Cited by 3 publications

References 12 publications

Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Imaging features of retroperitoneal extra‐adrenal paragangliomas in 10 dogs

Concurrent extra‐adrenal paraganglioma and uterine leiomyosarcoma in a degu (Octodon degus)

Subcutaneous ureteral bypass for treatment of bilateral ureteral obstruction in a cat with retroperitoneal paraganglioma

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