Malignant Ossifying Fibromyxoid Tumors: A report of two rare cases displaying retained INI1/SMARCB1 expression

Rekhi, Bharat; Thorat, Swati; Parikh, Gopal; Jambhekar, Nirmala A.

doi:10.4103/0377-4929.142717

Cited by 5 publications

(3 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…7,16 CD10 positivity has also been documented in a case of OFMT with atypical histologic features. 1,13 Recently, Graham et al 7 have described a characteristic ''mosaic'' pattern of loss of INI1/SMARCB1, unlike other authors 14 who observed retained INI1 expression in 2 malignant OFMTs (Figure 3, C).…”

Section: Pathologic Featuresmentioning

confidence: 93%

See 1 more Smart Citation

Ossifying Fibromyxoid Tumor: An Update

Bakiratharajan¹,

Rekhi

2016

Archives of Pathology &Amp; Laboratory Medicine

Self Cite

View full text Add to dashboard Cite

Ossifying fibromyxoid tumor (OFMT) is a rare soft tissue neoplasm of uncertain differentiation, initially described by Enzinger and colleagues. Until now, nearly 300 such cases have been reported worldwide. The histogenesis of these tumors remains controversial. These tumors show characteristic imaging findings and exhibit a spectrum of histopathologic features, including classical and atypical subtypes. Local recurrences and, occasionally, distant metastases have also been reported. A complete tumor resection forms the preferred treatment modality for these tumors, along with follow-up, as these tumors have an uncertain malignant potential. Lately, certain “molecular signatures” underlying OFMTs have been described that can further aid in reaching an accurate diagnosis for these tumors and unraveling their pathogenesis. This article is a review of the clinical, radiologic, histopathologic, and molecular features of OFMTs.

show abstract

Section: Pathologic Featuresmentioning

confidence: 93%

“…While one of these reported cases showed recurrence, the other 2 cases lacked follow-up. 8,14 Therefore, existence of fully malignant OFMTs is still a subject of discussion.…”

Section: Pathologic Featuresmentioning

confidence: 99%

Ossifying Fibromyxoid Tumor: An Update

Bakiratharajan¹,

Rekhi

2016

Archives of Pathology &Amp; Laboratory Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…2 However, INI-1 conserved expression has been identified in other studies, and the molecular mechanisms of this event in OFMT remain unclear. 23 To the best of our knowledge, this is the first intraoral OFMT case reported in the English-literature that analyzed the immunoreactivity of INI-1. An intact nuclear expression was observed in all tumor cells.…”

Section: Discussionmentioning

confidence: 83%