Malignant Obstructive Cholangiopathies Mimicking Primary Sclerosing Cholangitis

Resolution of Diffuse Intrahepatic Biliary Strictures after Chemotherapy for Metastatic Ovarian Cancer

“… 4 To our knowledge, only one case that documents SSC caused by ovarian cancer has been reported. 5 Unlike our patient, however, that patient had focal areas of liver metastasis and ultimately required surgery. 5 …”

“… 5 Unlike our patient, however, that patient had focal areas of liver metastasis and ultimately required surgery. 5 …”

“… 1 , 2 SSC has also occurred in cases of metastatic disease of the ovaries, prostate, gallbladder, pancreas, and colon/rectum. 5 , 7 - 9 Approximately half of patients with SSC are asymptomatic, but common clinical manifestations include generalized fatigue and pruritis. 10 Abdominal pain, fever, and jaundice can also occur with cholestasis or cholangitis.…”

Diagnosis of Secondary Sclerosing Cholangitis by Port Site Metastasis

“…Diffuse multifocal biliary strictures from SSC due to malignancy is a very uncommon phenomenon. Case reports have documented SSC secondary to lymphoma as well as metastatic prostate, ovarian, and gallbladder cancers [3][4][5][6]. Lew et al documented complete resolution of SSC findings via ERCP after successful treatment of metastatic ovarian cancer [7].…”

Primary Sclerosing Cholangitis

“…The most common secondary causes of sclerosing cholangitis include ischemia (arising from operative trauma, hepatic arterial infusion of floxuridine, allograft rejection), recurrent biliary sepsis, multifocal cholangiocarcinoma, AIDS, and toxic agents (formaldehyde, absolute alcohol) [15][16][17][18][19][20][21][22][23][24]. Radiographically, secondary causes of sclerosing cholangitis simulate PSC but the clinical course and therapeutic options may differ considerably.…”