Malignant nodular hidradenoma of the skin: report of seven cases

Souvatzidis, P; Sbano, Paolo; Mandato, Filomena; Fimiani, Michele; Castelli, Alberto

doi:10.1111/j.1468-3083.2007.02504.x

Cited by 58 publications

(111 citation statements)

References 32 publications

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“…There may be a large or small representation of cells showing squamoid differentiation. However, a diversity of cell types, such as polygonal cells, clear cells, and spindle cells may be seen [1,2]. The cells express the high molecular weight cytokeratins CK5/6 and CK7, as well as p63, androgen receptor, estrogen receptor, and sometimes Her-2/neu.…”

Section: Discussionmentioning

confidence: 99%

“…Even after the complete excision MNH has a potential for local recurrence, tends to metastasize, and often cause death [7]. In a report of seven cases from Italy, six patients died within 15-45 months of diagnosis [1]. Wide local excision is the treatment of choice with clearances of 2 cm recommended.…”

Section: Discussionmentioning

confidence: 99%

“…Malignant nodular hidradenoma (MNH) is an infrequent, highly malignant, primary skin tumor which may have both apocrine and eccrine variants [1]. Several synonyms have been described in the literature, like malignant clear cell myoepithelioma, malignant acrospiroma, clear cell hidradenocarcinoma, clear cell eccrine carcinoma, clear cell hidradenoma, solid-cystic hidradenoma and eccrine acrospiroma.…”

Section: Introductionmentioning

confidence: 99%

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Malignant Nodular Hidradenoma of the Scalp: A Case Report

2017

Ann Clin Anal Med

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ÖzMalign nodüler hidradenoma (MNH) nadir bir deri eki tümörüdür. Kafa derisi bu tü-mör için alışılmadık lokalizasyonlardan biridir. Bu çalışmada, kafa derisinde yavaş büyüyen kitle ile başvuran ve histopatolojik değerlendirme sonucu malign nodüler hidradenom tanısı alan 80 yaşında kadın hastayı sunmayı amaçladık. MNH müm-kün olduğu kadar erken tanı alması ve cerrahi olarak geniş rezeksiyon yapılması gereken agresif bir tümördür. Buna karşın erken rekürrens sık olduğundan yakın klinik takip gerektirir. Anahtar KelimelerDeri Eki Tümörü; Kafa Derisi; Karsinom; Malign Nodüler Hidradenom AbstractMalignant nodular hidradenoma (MNH) is a rare sweat gland tumor of the skin.The scalp is an uncommon site of occurrence. We, herein, present an 80-year-old woman whose slow-growing subcutaneous nodule on her scalp was diagnosed as malignant nodular hidradenoma after histopathologic examination. MNH is an aggressive tumor and should be diagnosed and excised as early as possible. Wide local excision is the treatment of choice. As early recurrence is common despite the wide excision close follow-up is necessary.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Malignant Nodular Hidradenoma of the Scalp: A Case Report

2017

Ann Clin Anal Med

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“…For benign but unsightly facial forms, electrocoagulation is the treatment of choice. The surgery of the giant and highly vascularized forms will be followed by a good haemostasis of the site and preferably drainage [13]. The management of the malignant form is multidisciplinary.…”

Section: Discussionmentioning

confidence: 99%

Giant Hidradenoma of Limbs: A Report of Two Pediatric Cases

Jlalia¹,

Bahroun²,

Kamoun³

et al. 2017

J Orthop Oncol

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Hidradenoma is a rare benign tumor that develops of the eccrine sweat glands. We report here two cases of benign giant hidradenoma with a clear cell variant in one case and nodular in the other. The tumor was localized on the forearm in a patient aged 6 years and in the foot in a 14-year-old child. An excisional biopsy was performed in both patients. Evolution was marked by a good outcome without recurrence. We try through this paper to review an uncommon tumor which his eccrine origin is controversial and which biological behavior was badly known.

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“…The vast majority of hidradenomas are benign neoplasms that are cured with complete excision. However, malignant hidradenomas, alternatively called hidradenocarcinomas, display more aggressive behavior, including local recurrence and distant metastases [19,20,21,22,23]. Between these two extremes is a group of tumors characterized as atypical hidradenomas.…”

Section: Introductionmentioning

confidence: 99%

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

Rooper

Iding

Cuda³

et al. 2016

Acta Cytologica

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Background: Fine-needle aspiration (FNA) is well-established as an accurate technique for the diagnosis of palpable breast masses. While the differential diagnosis of such lesions usually focuses on benign or malignant mammary proliferations, a subset of breast neoplasms arises from skin and soft tissue. Skin adnexal neoplasms such as hidradenoma can pose a particular pitfall on breast FNA cytology (FNAC) as epithelial proliferations that are not of ductal or lobular origin. Case: A 59-year-old female presented with a superficial breast mass. FNAC revealed a hypercellular lesion with marked nuclear atypia that was highly suspicious for carcinoma. However, at partial mastectomy, the histological features of the tumor were consistent with atypical hidradenoma. Negativity for estrogen receptor (ER) and progesterone receptor (PR) confirmed the diagnosis. Eighteen years later, the patient remains free of recurrence or metastasis. Conclusions: This report offers the first description of findings of atypical hidradenoma on FNAC. In the breast, its high cellularity and nuclear atypia can mimic a primary mammary carcinoma on FNAC. Although breast and skin adnexal tumors show a immunohistochemical overlap, negative ER and PR stains in a low-grade tumor can suggest a nonmammary lesion. Skin adnexal neoplasms should be considered in the differential diagnosis of superficial breast tumors.

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Malignant nodular hidradenoma of the skin: report of seven cases

Cited by 58 publications

References 32 publications

Malignant Nodular Hidradenoma of the Scalp: A Case Report

Malignant Nodular Hidradenoma of the Scalp: A Case Report

Giant Hidradenoma of Limbs: A Report of Two Pediatric Cases

Atypical Hidradenoma Mimicking Primary Mammary Carcinoma on Breast Fine-Needle Aspiration: A Case Report with Long-Term Follow-Up

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