Malignant nerve sheath tumour arising in a ganglioneuroma

Fletcher, Christopher D.�M.; Fernando, Indrajit; Braimbridge, M. V.; McKee, Phillip H.; Lyall, J. R. W.

doi:10.1111/j.1365-2559.1988.tb01959.x

Cited by 32 publications

(14 citation statements)

References 4 publications

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“…However, there have been at least seven documented cases of transformation of ganglioneuromas into malignant nerve sheath tumors. 3,5,7,8,11,14 Although malignant transformation involving the spindle cell component of a ganglioneuroma is a rare but proven event, to our knowledge, malignant transformation of the ganglion cell component into neuroblastoma has never been reported. The argument against this theory is that the neuronal component of a ganglioneuroma is presumably composed of mature, well-differentiated, postmitotic ganglion cells that should have lost the capacity to proliferate.…”

Section: Discussionmentioning

confidence: 98%

Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult

Kulkarni¹,

Bilbao²,

Cusimano³

et al. 1998

Journal of Neurosurgery

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Ganglioneuroma is generally considered to be a benign tumor and potentially surgically curable. The authors present a case of a 21-year-old woman who underwent resection of a retroperitoneal ganglioneuroma and developed spinal neuroblastoma 11 years later. She has survived 10 more years with only recent development of metastases. To the authors' knowledge, this is the first report of malignant transformation of a ganglioneuroma into a neuroblastoma. Also, such long-term survival in an adult with spinal neuroblastoma has not been reported previously. This case raises the possibility of a dedifferentiating potential for ganglion cells in a ganglioneuroma or the presence of a long-term, quiescent form of neuroblastoma.

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Section: Discussionmentioning

confidence: 98%

Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult

Kulkarni¹,

Bilbao²,

Cusimano³

et al. 1998

Journal of Neurosurgery

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“…In three of these cases the PNSTs arose following radiotherapy to primary neuroblastomas, and could be considered to be radiation-induced neoplasms 10,13 . In four cases the transformation into malignant PNSTs appears to have been spontaneous 1,4,7,8 . It is likely that these tumours arose as a result of malignant transformation in the stromal cell component of the ganglioneuroma with Schwann cells the most probable cell of origin, as the mature post-mitotic ganglion cells should have lost the capacity to proliferate 11,13 .…”

Section: Discussionmentioning

confidence: 95%

Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma

Patterson

Barker

Loukota

et al. 2009

International Journal of Oral and Maxillofacial Surgery

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“…Generally, ganglioneuromas appear secondary to maturation of a neuroblastoma or a ganglioneuroblastoma, although malignant degeneration of primary ganglioneuromas has also been described. 6,7 These tumors may demonstrate hormonal activity and secrete catecholamine as well as intestinal vasoactive peptide. They then cause diarrhea, distension of the abdomen, hot fl ushes, hypertension, and hypoglycemia.…”

Section: Discussionmentioning

confidence: 99%

Intrathoracic ganglioneuroma in an elderly patient over 70 years of age

Maruyama

Tanaka

Maehara

et al. 2007

Gen Thorac Cardiovasc Surg

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We herein present an exceedingly rare case of intrathoracic ganglioneuroma that was surgically resected in an elderly patient over 70 years of age. A 74-year-old woman was asymptomatic, but a computed tomography (CT) scan of the thorax indicated the presence of a posterior mediastinal mass paravertebrally. A thoracotomy was thus performed under a strongly suggested diagnosis of a neurogenic tumor because of the appearance and position of the mass on the chest CT and magnetic resonance imaging findings, and measuring 6.9 x 5.8 x 1.6 cm. Not only tumors originating from the nerve sheath, but also neurogenic tumors occurring in young patients such as ganglioneuroma, should be included in the different diagnosis of posterior mediastinal tumor occurring in elderly patients.

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Malignant nerve sheath tumour arising in a ganglioneuroma

Abstract: A malignant nerve sheath tumour arising within a thoracic ganglioneuroma is described. This is only the seventh such case described in the literature and the first at this site. The previously documented cases are reviewed.

Cited by 32 publications

References 4 publications

Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult

Malignant transformation of ganglioneuroma into spinal neuroblastoma in an adult

Ganglioneuroma of the mandible resulting from metastasis of neuroblastoma

Intrathoracic ganglioneuroma in an elderly patient over 70 years of age

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