Malignant Nephrosclerosis in Patients with Hemolytic Uremic Syndrome (Primary Malignant Nephrosclerosis)

Significance of Postglomerular Capillaries in the Pathogenesis of Chronic Renal Failure

“…4). In primary malignant nephros clerosis [22,23], which is always accompanied by the hae molytic-uraemic syndrome, we found no correlation be tween the relative area of the cortical interstitium and the serum creatinine concentration, or between the relative area of the intertubular capillaries and the serum creatinine con centration, because this disease is always accompanied by acute renal failure, which fundamentally influences the se rum creatinine concentration.…”

“…Neither is there general acknowledge ment that it is possible to distinguish two different types of malignant nephrosclerosis. There is a primary form, in which the vascular stenosis typical of nephrosclerosis de velops in the presence of normal blood pressure, and a sec ondary form, in which stenosis of the preglomerular vessels occurs as a result of overdilatation due to malignant hyper tension [22,23].…”

Die Klinik des h�molytisch-ur�mischen Syndroms

“…Die Letalit/it ist bei Erwachsenen sehr viel h6her (50%), eine ausgepr/igte Hypertonie geh6rt immer dazu und Ahnlichkeiten mit der malignen Hypertonie sind beschrieben [9,57]. Morphologisch wird dieser Zusammenhang besonders yon Bohle et al [6] beschrieben.…”

Haemolytic Uraemic Syndrome

“…In H US two different histopathological patterns are seen, although they may overlap. In the diarrhoea-associated variety of HUS there is pre dominantly glomerular capillary thrombosis with some arteriolar [13,14) ( f i g -1, 2 ).…”

“…HUS and TTP are part of a group of conditions in which thrombosis and necrosis of intra-renal vessels occurs in the absence of cellular inflammation. Synonyms for this histopathological constellation include malignant nephrosclerosis, thrombotic microangiopathy and proliferativearteriopathy [14][15][16]. In H US two different histopathological patterns are seen, although they may overlap.…”