Malignant mesothelioma of the tunica vaginalis: a case with an unusually indolent course following radical orchidectomy and radiotherapy.

Harmse, J. L.; Evans, AT; Windsor, Phyllis

doi:10.1259/bjr.72.857.10505018

Cited by 11 publications

(8 citation statements)

References 2 publications

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“…Malignant mesothelioma of the tunica vaginalis is a very rare neoplasm associated with highly aggressive biological behavior. [ 6 ] It commonly occurs in elderly age group with a rapidly progressive course. Few cases have been reported in the younger age group of <25 years[ 2 ] as it was observed in the index case reported.…”

Section: Discussionmentioning

confidence: 99%

Hydrocele with a surprise: Malignant mesothelioma of the tunica vaginalis - Case report and review of literature

et al. 2017

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Hydrocele is a very common condition that is simple to evaluate and treat. Management of hydrocele is usually delegated to the junior members of the surgical team. Sometimes this simple condition can spring huge surprises. A 20-year-old man presented with acute onset large, painless fluctuant left hemi-scrotal swelling. Scrotal ultrasonography showed thickened tunica vaginalis. A diagnosis of left hydrocele was made and repair by excision of sac was planned. During the procedure, the sac was found studded with red nodular growths; histopathology reported malignant mesothelioma of tunica vaginalis. Metastatic evaluation showed extensive retroperitoneal lymph nodal involvement. Despite receiving adjuvant chemotherapy with radiotherapy patient died due to extensive metastasis within 16 months. This case is presented for rarity of diagnosis, young age of presentation, absence of etiological factor and rapidly progressive clinical course.

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Section: Discussionmentioning

confidence: 99%

Hydrocele with a surprise: Malignant mesothelioma of the tunica vaginalis - Case report and review of literature

et al. 2017

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“…Mesothelioma cells react positivelywiththrombomodulin,cytokeratin5,andcalretinin [5,[7][8][9].Theprognosisofmesotheliomaisnotaffectedbythe histologicalpattern [10],butitseemsthatthereissomeassociation between the Ki-67 index and the prognosis of the disease [11]. Mesotheliomas with low Ki-67 index seem to haveabetterprognosis [9,12,13],buttherearealsostudies thatdonotconfirmanycorrelation [14].…”

Section: Discussionmentioning

confidence: 99%

“…In the adjuvantsetting,radiotherapyatadosageof40-60Gyisused to assure local disease control [1,8]. There are currently no guidelinesforadjuvantchemotherapyregimens.Inthisindication,manysubstanceshavebeentried.Themostcommonly used are cisplatin, pemetrexed, vinorelbin, and gemcitabine [1,4,5,10] based on regimens used for the treatment of malignantpleuralmesothelioma.…”

Section: Discussionmentioning

confidence: 99%

Cutaneous Recurrence of Malignant Mesothelioma of the Tunica Vaginalis Testis: a Rare Case Report

et al. 2012

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Background: Mesothelioma of the tunica vaginalis testis is a rare and aggressive cancer; fewer than 90 cases have been reported. It occurs in all age groups, but its highest incidence appears between 55 and 75 years of age. Less than 5% of all malignant mesotheliomas arise from the tunica vaginalis testis. Case Report: The authors present a rare case of localized malignant mesothelioma of the tunica vaginalis testis. Diagnosis and treatment are described. Conclusion: Mesothelioma of the tunica vaginalis testis can be asymptomatic for a long time. In more than half of the cases, the clinical manifestations imitate a hydrocele or a tumor mass in the scrotum. Despite treatment, this tumor has a very poor prognosis with a median survival of 23 months.

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“…Plas et al reported that the median survival period was 23 months, with a range of 2-64 months. 6 Only two of the 110 reported cases of radical orchidectomy survived more than 5 years, 7 which indicates that convalescence is very poor for this disease. Therefore, it is important to diagnose a malignant tumor as soon as possible, and then operate immediately.…”

Section: Discussionmentioning

confidence: 99%

Malignant mesothelioma of the tunica vaginalis testis related to recent asbestos

Ikegami¹,

Kawai

Tozawa³

et al. 2008

Int J of Urology

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Abstract:We report an extremely rare case of malignant mesothelioma in the tunica vaginalis testis. A 67-year-old man was referred to our hospital complaining of painless swelling in the right scrotum. Ultrasonography and computed tomography demonstrated a mass of approximately 6 cm in the right scrotum. He underwent tumor resection under a diagnosis of right intrascrotal tumor. The histopathological diagnosis was malignant mesothelioma, and he died 26 months later from multiple metastases. Asbestos may be a significant contributor to malignant mesothelioma in Japan. There have been 46 cases reported in urology departments in this country of the related symptoms, but only two of these have been clearly attributable to asbestos, which may be due to the investigations being insufficient to obtain a definitive diagnosis. In addition, this symptom is often diagnosed preoperatively as hydrocele testis; it is therefore important to carry out ultrasonography when a hydrocele testis has been diagnosed.

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Malignant mesothelioma of the tunica vaginalis: a case with an unusually indolent course following radical orchidectomy and radiotherapy.

Cited by 11 publications

References 2 publications

Hydrocele with a surprise: Malignant mesothelioma of the tunica vaginalis - Case report and review of literature

Hydrocele with a surprise: Malignant mesothelioma of the tunica vaginalis - Case report and review of literature

Cutaneous Recurrence of Malignant Mesothelioma of the Tunica Vaginalis Testis: a Rare Case Report

Malignant mesothelioma of the tunica vaginalis testis related to recent asbestos

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