Malignant mesothelioma of the tunica vaginalis propria testis in a patient with asbestos exposure—A case report

Fligiel, Zuzana; Kaneko, Mamoru

doi:10.1002/1097-0142(197603)37:3<1478::aid-cncr2820370333>3.0.co;2-g

Cited by 44 publications

(15 citation statements)

References 10 publications

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“…4,5,9,[11][12][13][14]18,19,21,22,27,28,37,38,40,43,45 Reviewing the available data for the 74 cases determined an incidence of primary disseminated disease in 14.9% (11 cases). All of these patients were older than 40 years, with a median age of 58 years.…”

Section: Histology and Invasionmentioning

confidence: 99%

Malignant mesothelioma of the tunica vaginalis testis

Plas

Riedl

Pflüger

1998

Cancer

173

134

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Section: Histology and Invasionmentioning

confidence: 99%

Malignant mesothelioma of the tunica vaginalis testis

Plas

Riedl

Pflüger

1998

Cancer

173

134

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“…In 1957, Barbera and Rubino2 described the first case of mesothelioma of the tunica vaginalis testis (MTVT), and since then, fewer than 230 cases have been reported 1 , 3. However, the first description of MTVT associated with asbestos was held by Fligiel and Kaneko in 1976 4. MTVT might be considered to be a variation of peritoneal mesothelioma, since the peritoneal lining extends into the scrotal sac 3 , 5.…”

Section: Discussionmentioning

confidence: 99%

“…MTVT might be considered to be a variation of peritoneal mesothelioma, since the peritoneal lining extends into the scrotal sac 3 , 5. Since the description of Fligiel and Kaneko4 the association of MTVT and asbestos exposure has been widely reported 6 - 11. This association was noted to occur between 34% and 42% of the cases,8 , 9 although this is considered to be underestimated because of insufficient clinical information.…”

Section: Discussionmentioning

confidence: 99%

Malignant paratesticular mesothelioma

Fonseca¹,

Marques²,

Takahashi³

et al. 2014

ACR

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Mesothelioma of the tunica vaginalis testis (MTVT) is a rare tumor that usually affects patients after the sixth decade of life. Exposure to asbestos is a known risk factor. Enlargement of the scrotal volume is the most common initial clinical manifestation, and about 15% of cases present metastasis at diagnosis. The treatment relies on surgical resection while the role of adjuvant chemotherapy and radiotherapy remains unclear. The prognosis for patients is generally poor, with a lethal outcome in 30% over a 24-month period. The authors report a case of a 62-year-old patient with the diagnosis of MTVT without a history of asbestos exposure. After surgical treatment, metastatic disease ensued. Chemotherapy was initiated, but could not be continued due to marked and fast clinical deterioration. The authors call attention to the difficulty of early diagnosis of MTVT due to a nonspecific clinical picture, the lack of action by the patient when the scrotal enlargement was first noticed, and the lack of tumor markers. Delayed diagnosis is definitely related to unfavorable prognosis.

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“…For example, under German law, the occurrence of a malignant mesothelioma of the testis is evidence of occupational disease for asbestos workers [8]. The latent period between exposure and development of the tumor may be up to 40 years [10].…”

Section: Treatmentmentioning

confidence: 99%

Malignant gonadal mesothelioma

Gupta

Kumar²

2002

Curr. Treat. Options in Oncol.

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Malignant mesothelioma of the gonads is a rare and highly lethal disease. Most of these tumors arise from the tunica vaginalis, which is a continuation of the mesothelium similar to the pleura and the peritoneum. However, intratesticular and ovarian mesotheliomas have also been described. Occasionally, patients with localized disease at the time of detection have been known to survive for more than 10 years; however, the majority will not live beyond 5 years, with median survival being approximately 23 months. The principle reasons for this are difficulty in making a preoperative diagnosis and advanced stage at the time of treatment. Surgery forms the mainstay of management for all stages of the tumor. Adjuvant therapy in the form of chemotherapy, immunotherapy, or radiotherapy has negligible benefit. It is essential to diagnose this rare entity at the early stages to allow complete surgical extirpation. For the management of localized disease, we suggest the following protocol: initial staging of suspected cases with computed tomographic scan of the abdomen and pelvis; radical inguinal orchiectomy or hemiscrotectomy; retroperitoneal lymph node dissection in cases with positive nodes on scan or biopsy; and inguinal node dissection in cases requiring hemiscrotectomy. For advanced or recurrent disease, we suggest local radical resection with chemotherapy, including high-dose cisplatin and doxorubicin for two cycles of 5 days each; add local radiotherapy for uncontrolled locally advanced disease.

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Malignant mesothelioma of the tunica vaginalis propria testis in a patient with asbestos exposure—A case report

Cited by 44 publications

References 10 publications

Malignant mesothelioma of the tunica vaginalis testis

Malignant mesothelioma of the tunica vaginalis testis

Malignant paratesticular mesothelioma

Malignant gonadal mesothelioma

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