Malignant Mesothelioma and Radiological Chest Abnormalities in Two Villages in Central Turkey

Barış, Y. İzzettin; Simonato, Lorenzo; Saracci, Rodolfo; Skidmore, J. W.; Artvinli, M

doi:10.1016/s0140-6736(81)91742-6

Cited by 115 publications

(56 citation statements)

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“…[5,6] Since respiratory exposure to asbestos which plays a pivotal role in the etiology pleura is the most commonly (90%) encountered location. [4,7,8] In a number of series published, exposure to asbestos has been reported in 50-80% of cases with malignant pleural mesothelioma. In our study, six (11.3%) patients declared exposure to asbestos by anamnesis.…”

Section: Discussionmentioning

confidence: 99%

Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Gul¹

2017

TJ Oncol

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OBJECTIVEA single-institution study of 7 years of experience was performed to investigate the clinicopathological and therapeutic characteristics of malignant pleural mesothelioma (MPM) patients who received multimodality treatment, as well as factors affecting survival. METHODSA retrospective review of a consecutive cohort of pathologically confirmed MPM patients who were referred to our radiation oncology clinic and received multimodality treatment strategy that included surgery, chemotherapy, and radiotherapy at our training and research hospital between 2001 and 2008 was performed. RESULTSA total of 53 patients were included in the study. Median age was 58 years (range: 33-79 years). Mean duration of follow-up was 14 months (range: 4-82 months). Disease-free status and overall survival were 11 months (range: 3-50 months) and 14 months (range: 4-82 months), respectively. Factors that individually predicted better prognosis were younger age (<50 years), having undergone surgery, having received radiotherapy, and having undergone multimodality treatment. CONCLUSIONFurther comprehensive and randomized studies are required to better understand biological behavior of MPM in order to obtain more successful results in the management of the disease.

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Section: Discussionmentioning

confidence: 99%

Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Gul¹

2017

TJ Oncol

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“…Endemic mesothelioma in the Turkish villages of Karain and Tuscoy has been attributed to the inhalation of zeolite fibres (Baris et al, 1981) or to the inhalation of zeolite and asbestos fibres acting synergistically (Rohl et al, 1982). This has stimulated interest in the oncogenic activity of the zeolite fibres as compared with that of other mineral fibres.…”

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confidence: 99%

In vitro genotoxic activities of fibrous erionite

Poole¹,

Brown²,

Turver³

et al. 1983

Br J Cancer

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A high incidence of mesothelioma has been reported from some villages in Cappadocia, Turkey. This type of cancer is usually associated with the inhalation of asbestos, but on the basis of the most prevalent fibre in the dust from these villages, the Turkish outbreak has been attributed to the inhalation of zeolite fibres. A counter hypothesis, based on the detection of very small quantities of chrysotile and tremolite in strata samples and human lung tissue, postulates a significant role of these minerals as one of several factors contributing to pleural disease. A respirable fraction of erionite, (from Oregon, USA, but with similar characteristics to the fibres found in Turkey), has some in vitro genotoxic properties associated with many conventional carcinogens. In this study these fibres caused an increase in morphological transformation and unscheduled DNA repair synthesis (UDS) in C3H10T1/2 cells and UDS in the human lung cell line--A549. It is therefore suggested that exposure to fibrous erionite alone may be sufficient to cause the high incidence of pleural tumours observed in Turkey. Images Figure 1 Figure 3

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“…In villages built with stones mined from the nearby natural caves in Cappadocia, a region in Central Anatolia, Turkey, at least 50% of deaths are caused by malignant mesothelioma. [13][14][15][16][17] When Baris et al 13 discovered a very high incidence of mesothelioma in the village of Karain, scientists looked for asbestos, and some asbestos was found; 18 however, additional studies demonstrated that asbestos is omnipresent in Cappadocia because it is a natural component of that volcanic terrain and because asbestostremolite-based stucco has been widely used in building construction in all Cappadocian villages. 14 -17,19 Hence, asbestos could not account for the uniquely high incidence of mesotheliomas in these three villages.…”

Section: Genetic Predispositionmentioning

confidence: 99%

Evolving Aspects of Mesothelioma Carcinogenesis: SV40 and Genetic Predisposition

Carbone

Pass

2006

Journal of Thoracic Oncology

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M alignant mesothelioma is characterized by a long latency from the time of exposure to asbestos to the onset of disease, which suggests that multiple somatic genetic events are required for tumorigenic conversion of a normal mesothelial cell. Epidemiological studies have established that exposure to asbestos fibers is the primary cause of malignant mesothelioma 1,2 , and recent investigations have implicated simian virus 40 (SV40) and genetic predisposition in the etiology of some malignant mesothelioma. SV40SV40 is a DNA tumor virus that is endogenous in rhesus monkeys and is now widespread among the human population. The modes by which the virus was transferred from monkey to human are uncertain, but it is possible that the bulk of this transfer may have occurred from 1954 to 1963 through SV40-contaminated polio vaccines administered worldwide. 3 SV40 can be excreted via human feces, breast milk, and semen 4 , and Butel et al. 5 and Butel and Lednicky 6 have reported that 5.9% of 377 Texas children born between 1980 and 1995 had SV40-neutralizing antibodies. SV40 produces two oncogenic proteins, the large and small t antigens. 2,4 The large T antigen (Tag) is capable of inducing structural and numerical chromosomal alterations. Tag also induces insulin-like growth factor expression and inhibits p53 and the pRb family, and it induces c-met activity to stimulate cell proliferation. 3,4 The small t antigen (tag) inhibits cellular phosphatase 2A, stimulates MAP kinase and AP-1 activity, and works with Tag to bind and inhibit p53 and pRb. 3 The combined activity of both the large Tag and the small tag induce Notch-1 and telomerase activity, which are required for malignant transformation and immortalization. 7,8 Analysis of human mesotheliomas for the virus revealed that SV40 sequences were present in 29 of 48 human mesothelioma samples (60%). Sequence analysis confirmed that the virus detected was SV40. 9 Polymerase chain reaction analysis, mRNA in situ hybridization, microdissection, and immunostaining techniques used in several studies have also shown that SV40 sequences and antigens are found in tumor cells but not in the normal adjacent tissue. 2,4 Although more than 60 laboratories have found SV40 in human mesotheliomas and other tumors, the virus was not detected in Finnish, Austrian, and Turkish mesothelioma specimens, 2-4 which suggests that the presence of SV40 in human tumors may be influenced by geographic factors. One of these factors may be related to polio vaccine distribution, because SV40-contaminated polio vaccines were not administered in Finland, Austria, and Turkey. 2,3 Three independent panels have reviewed and confirmed the association of SV40 with human tumors, especially mesothelioma. 10 -12 Human mesothelial cells are unusually susceptible to SV40 infection compared with fibroblasts. [3][4][5] In mesothelial cells, Tag binds p53 and inhibits its tumor suppressor activity. At the same time, the interaction inhibits the ability of the virus to replicate, which ultimately leads to prolonge...

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Malignant Mesothelioma and Radiological Chest Abnormalities in Two Villages in Central Turkey

Cited by 115 publications

References 3 publications

Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

Clinicopathological and Survival Characteristics of Malignant Pleural Mesothelioma: A Single-Institutional Experience

In vitro genotoxic activities of fibrous erionite

Evolving Aspects of Mesothelioma Carcinogenesis: SV40 and Genetic Predisposition

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