Malignant mesenchymal tumors of the ovary in three cases: Histology, immunohistochemistry, and ultrastructural observations

Khan, Salma; Katabuchi, Hidetaka; Okamura, Yosuke; Matsumura, Sayuri; Nagai, Ryo; Ohtake, Hideyuki; Suenaga, Yoshito; Fukumatsu, Y.; Ikuta, Yukio; Okamura, Hitoshi

doi:10.1007/bf01545703

Cited by 5 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…3,4,6,7,9,13,14,17,18,24,25,31,38,39,41,43,45,56,61,63,66,67,75,79,83,84,86,88,99,100,102,111 Fewer than 10% of patients are younger than 30 years. 3,4,6,7,9,13,14,17,18,24,25,31,38,39,41,43,45,56,61,63,66,67,<...>…”

Section: Discussionmentioning

confidence: 99%

“…97 It is therefore of note that a single case interpreted as ovarian leiomyosarcoma has been reported in a 20-year-old with the syndrome. 3,6,7,9,24,31,41,45,56,66,67,75,86 Because of the rarity of ovarian smooth muscle tumors, criteria for distinguishing leiomyoma from leiomyosarcoma at this site have long been elusive. 4 Both conventional and myxoid ovarian leiomyosarcomas are aggressive like their uterine counterparts.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Smooth Muscle Tumors of the Ovary

Lerwill¹,

Sung²,

Oliva³

et al. 2004

American Journal of Surgical Pathology

112

View full text Add to dashboard Cite

We studied 54 ovarian smooth muscle tumors with an emphasis on histologic criteria for malignancy. Twenty-two leiomyomas were identified, including 7 typical, 11 cellular, 2 mitotically active, 1 with bizarre nuclei, and 1 myxoid. Follow-up ranging from 12 to 240 months (mean, 77.6 months) was available for 14 patients; all were alive with no evidence of disease. Of 26 leiomyosarcomas, including 2 myxoid leiomyosarcomas, most were readily diagnosed by the presence of at least two of the following: moderate or severe cytologic atypia, mitotic rate > or =10 mitotic figures per 10 high power fields, and tumor cell necrosis. Some cytologically atypical tumors demonstrated lesser mitotic activity of 5 to 9 mitotic figures per 10 high power fields, in the absence of tumor cell necrosis. Sixty percent of these were clinically malignant, supporting a diagnosis of leiomyosarcoma in such tumors. Follow-up was available for 21 patients. Seventy-one percent developed recurrent disease at a mean of 19 months, and 62% died of their disease at a mean of 24 months. Four tumors were deemed of uncertain malignant potential, and two that were stage II both recurred in the pelvis. One case of ovarian intravenous leiomyomatosis had a benign outcome at 42 months, as did one case of ovarian leiomyoma with leiomyomatosis peritonealis disseminata at 180 months. Overall, ovarian smooth muscle tumors encompass the same varied histologic spectrum as their uterine counterparts. The main tumors in the differential diagnosis are those in the fibroma/thecoma category, spindle cell carcinomas, and metastatic gastrointestinal stromal tumors.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Smooth Muscle Tumors of the Ovary

Lerwill¹,

Sung²,

Oliva³

et al. 2004

American Journal of Surgical Pathology

112

View full text Add to dashboard Cite

show abstract

“…Ovarian fibrosarcoma shows marked cellular pleomorphism and brisk mitotic activity similar to that seen in other locations. Typically, spindle‐shaped tumor cells are arranged in a herringbone pattern around vascular spaces of various sizes and shapes (17) . In addition to reticulum stains, electron microscopy and immunohistochemical techniques are helpful to distinguish hemangiopericytoma from the above described tumors.…”

Section: Discussionmentioning

confidence: 99%

A case of metastatic malignant hemangiopericytoma of the ovary: Recurrence after a period of 17 years from intracranial tumor

Begum

Katabuchi

Tashiro

et al. 2002

Int J Gynecol Cancer

View full text Add to dashboard Cite

Hemangiopericytoma is an uncommon vascular tumor. Primary or metastatic hemangiopericytoma of the ovary is extremely rare. A 48-year-old Japanese woman had a tumor in the neck. Simultaneously, a solid ovarian tumor was detected. She had received treatment for intracranial hemangiopericytoma 17 years previously. For the ovarian tumor, she underwent a total abdominal hysterectomy and bilateral salpingo-oophorectomy. The left ovarian tumor weighed 1510 g and its cut surface was solid without areas of hemorrhage or necrosis. It was microscopically composed of tightly packed tumor cells outside of many vascular vessels. One or two mitotic figures were counted per 10 high power fields. Immunohistochemically, vimentin was expressed but factor-VIII-related antigen, CD 31, and CD 34 were not expressed in the tumor cells. Electron microscopy showed that the tumor cells were grown outside of the endothelium-lined vascular spaces. A discontinuous external basal lamina was also observed. We present a case of metastatic malignant hemangiopericytoma of the ovary from a primary intracranial hemangiopericytoma with a long interval of 17 years.

show abstract

Synovial sarcoma arising from the pleura: a case report with ultrastructural and immunohistological studies

Honda

Kizaki

Sashikata

et al. 2002

Medical Electron Microscopy

View full text Add to dashboard Cite

Synovial sarcoma commonly occurs in the para-articular regions of the extremities, and rarely in the pleura. We report a 46-year-old woman with primary synovial sarcoma of the pleura. She was admitted with a complaint of left-sided chest pain and exertional dyspnea. She had previously undergone two operations for pleural neoplasm, at the ages of 33 and 36 years. A computed tomography scan revealed an expanded mass in the left thoracic cavity, involving the surrounding tissue. Macroscopic findings demonstrated a 25 x 25 x 15-cm grayish-white mass with hemorrhage beneath the pleura. Both epithelial and spindle cells were observed microscopically. Ultrastructural microscopy of the epithelioid cells demonstrated short, blunt microvilli on the luminal surface, and desmosomes between the neoplastic cells. Immunohistochemically, the tumor cells of the epithelial component were positive for embryonal membrane antigen (EMA), carcinoembryonic antigen (CEA), human mesothelial cells (HBME)-1, and cytokeratin, and the spindle cells were positive for vimentin. These findings led us to a diagnosis of primary synovial sarcoma of the pleura. She had no evidence of recurrence or metastasis after the third operation.

show abstract

Malignant mesenchymal tumors of the ovary in three cases: Histology, immunohistochemistry, and ultrastructural observations

Cited by 5 publications

References 11 publications

Smooth Muscle Tumors of the Ovary

Smooth Muscle Tumors of the Ovary

A case of metastatic malignant hemangiopericytoma of the ovary: Recurrence after a period of 17 years from intracranial tumor

Synovial sarcoma arising from the pleura: a case report with ultrastructural and immunohistological studies

Contact Info

Product

Resources

About