Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde.

Holmström, Mats; Lund, VJ

doi:10.1136/oem.48.1.9

Cited by 55 publications

(54 citation statements)

References 23 publications

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“…A smoking history and formaldehyde exposure are believed to be potential risk factors for oral and nasal melanomas [11,12]. However, in this study, data on potential formaldehyde exposure were not collected, and there was no evidence supporting a pathogenic role of tobacco use.…”

Section: Discussionmentioning

confidence: 42%

Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

Zhu

Zou²,

Wang³

2016

ORL

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Aims: Sinonasal mucosal malignant melanoma (SNMMM) is a rare disease. The aim of the present study was to describe its clinicopathological features and prognosis in a Chinese population. Methods: Data on 83 SNMMM patients were collected and analyzed. A survival analysis was performed using the Kaplan-Meier method and a log-rank test. Results: The most common presenting symptoms of SNMMM were nasal obstruction, epistaxis, and bloody rhinorrhea. Histopathologically, 38 cases (45.78%) were amelanotic. Five cell types (epithelioid, undifferentiated, plasmacytoid, spindle, and clear) were identified. Positive staining for human melanoma black-45 and Melan-A was diagnostic of SNMMM. Advanced age, multiple tumor sites, and amelanotic-type SNMMM indicated a worse outcome (p = 0.008, p = 0.009, and p = 0.013, respectively). Neither adjuvant therapy nor the tumor stage was associated with overall survival. Conclusions: SNMMM is an uncommon disease with atypical symptoms. Its histopathological appearance is variable, especially in the amelanotic type. Thus, immunohistochemistry is important in the diagnosis, and it should be performed according to the histology.

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Section: Discussionmentioning

confidence: 42%

Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

Zhu

Zou²,

Wang³

2016

ORL

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“…Formaldehyde and smoking are listed as risk factors. In workers professionally exposed to formaldehyde fumes, cases of sinonasal melanomas have been reported 2 . Swedish authors mention the more prevalent pigmentation of oral mucosa in smokers, deeming it to be a risk factor for OM 3 .…”

Section: Introductionmentioning

confidence: 99%

Primary Oral Mucosal Melanomas – Two Case Reports and Comprehensive Literature Review

Topić

Masic

Radović

et al. 2017

acc

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SUMMARY -Oral melanoma (OM) occurs from activated or genetically altered epidermal melanocytes. Th ere is no scientifi c evidence that OM can be linked to physical, chemical and thermal irritation, or to other risk factors of the oral cavity. According to fi gures from various countries, OM accounts for 0.2% to 7.5% ( Japan) of all cases of melanoma of the skin and mucous membrane. Th e male to female ratio of OM is 2:1. About 80% of OMs are located in the mucosa of the palate and maxillary gingiva. Th is paper presents two cases of oral mucosal melanoma of the upper and lower lips in women aged 62 and 59 years. Diagnosis, diff erential diagnosis and therapy are reported.

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“…Exposure to formaldehyde in case of sinonasal type and cigarette smoking in case of oral melanomas has been suggested as the possible risk factors. 5,6,7 Curtin et al 8 in his research study showed that genetic mutations and/or increased copy number of KIT (Receptor tyrosine kinase) in 39% of mucosal melanomas.…”

Section: Discussionmentioning

confidence: 99%

A Case Report of Primary Melanotic Tumour of the Nasal Cavity

M¹,

Suhas²,

Ravi³

et al. 2016

jemds

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Primary mucosal melanomas arise from melanocytes located in occult sites and can present along the mucosal membranes lining respiratory, gastrointestinal, and urogenital tract. Sinonasal melanomas are extremely rare. Infrequent tumour incidence has limited the insight about their pathogenesis and associated risk factors along with indefinite protocols for staging and treatment of mucosal melanomas. We report here a case of primary melanotic tumour involving the nasal cavity, which was detected at an early stage and operated. We also describe the histological features, imaging studies, and treatment options for this tumour along with a brief literature review. KEYWORDSMucosal Melanoma, Nasal Tumours, Lateral Rhinotomy. Majority of the melanomas are cutaneous in origin. Cutaneous tumours can develop anywhere on the skin, but are more likely to start on the trunk, chest, and back) in males and on the legs in females. 3 Unlike cutaneous melanomas, primary mucosal melanomas arise from melanocytes located in occult sites and can present along the mucosal membranes lining respiratory, gastrointestinal, and urogenital tract. The sinonasal melanomas are extremely rare and accounts for less than 1% of all melanomas. The rarity of the mucosal melanomas have limited the understanding of possible risk factors and the pathogenesis of this disease resulting in inadequacy of precise treatment options. We report here a rare case of melanoma of nasal cavity, which was diagnosed at an early stage and operated and the biopsy of which affirmed to be malignant mucosal melanoma. We also briefly discuss about cases reported in the past along with a literature review. HOW TO CITE THIS ARTICLE:

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Malignant melanomas of the nasal cavity after occupational exposure to formaldehyde.

Cited by 55 publications

References 23 publications

Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

Clinicopathological Features and Prognosis of Sinonasal Mucosal Malignant Melanoma: A Retrospective Study of 83 Cases in a Chinese Population

Primary Oral Mucosal Melanomas – Two Case Reports and Comprehensive Literature Review

A Case Report of Primary Melanotic Tumour of the Nasal Cavity

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