Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid

Goodall, Peter; Spriggs, A. I.; Wells, F. R.

doi:10.1002/bjs.18004821119

Cited by 25 publications

(14 citation statements)

References 13 publications

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“…The reticuloendothelial cells of the liver and spleen (Albertini et al 1927, Dixon 1938, Ritz 1949, Goodall et al 1961, Sohn et al 1969, bone marrow (Albertini et al 1927, Goodall et al 1961) and lymph nodes (Albertini et al 1927, Dixon 1938, Goodall et al 1961, Sohn et al 1969, are loaded with pigment, and various parenchymal cells, such as renal tubular cells (Albertini et al 1927, Way et al 1930, Dixon et al 1938, Ritz 1949, Goodall et al 1961, Sohn et al 1969, thyroid cells (Goodall et al 1961), and adrenals (Goodall et al 1961, Sohn etal. 1969, may contain melanin granules.…”

Section: Discussionmentioning

confidence: 99%

“…Macrophages and monocytes are involved in transport of pigment (Albertini et af. 1927, Liebmann 1929, Alexander & Spriggs 1960, Goodall et al 1961, Silberberg et al 1968. Melanoma cells carry with them pigment and may infiltrate an organ in a single cell fashion, as demonstrated in the skin by Konrad er al.…”

Section: Discussionmentioning

confidence: 99%

“…Diffuse melanosis in malignant melanoma is clinically characterized by a striking argyria-like slate-blue discolouration of the skin and melanuria (Albertini & Walthard 1927,Odel & Horton 1937, Dixon 1938, Albeaux-Fernet, Laumonier & Collart 1949, Ritz 1949, Fitzpatrick, Montgomery & Lerner 1954, Goodall & Spriggs 1961, Silberberg, Kopf & Gumport 1968, Bork, Korting & Rumpelt 286 J.Eide 1977. The bluish colour is due to deposition of melanin pigment in the deeper part of the dermis (Ode1 & Horton 1937, Albeaux-Fernet et al 1949, Fitzpatrick et al 1954, Goodall & Spriggs 1961, Silberberg et al 1968, ,Holcomb et al 1975, Bork et al 1977.…”

Section: Introductionmentioning

confidence: 99%

“…The bluish colour is due to deposition of melanin pigment in the deeper part of the dermis (Ode1 & Horton 1937, Albeaux-Fernet et al 1949, Fitzpatrick et al 1954, Goodall & Spriggs 1961, Silberberg et al 1968, ,Holcomb et al 1975, Bork et al 1977.…”

Section: Introductionmentioning

confidence: 99%

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Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Eide

1981

Histopathology

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A case of disseminated malignant melanoma with generalized melanosis of the skin and other tissues, melanuria, melanoptysis, and a dark brown blood serum is reported. The reticuloendothelial system contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally contained large amounts of melanin pigment. Lysis of degenerating pigment-loaded melanoma cells in peripheral blood vessels seemed to be of considerable importance in the pigmentation of tissues. Focal pigmentation of capillary endothelium and perivascular deposition of melanin pigment in macrophages and, occasionally, in other cells, was noted. Single cell metastases contributed to melanin pigmentation of most organs, but were not found in sections of the skin. Melanoptysis (black sputum) was due to diffuse melanoma cell infiltration of the lungs, with secondary pigment deposition in macrophages and in bronchial epithelial cells. In this case the 'glomerular melanoma cell emboli' recorded by previous authors consisted of melanin pigment and cell debris. Focal damage of glomeruli affected by pigment emboli is described allowing access of melanoma cell debris (including melanin pigment granules) into glomerular tubules.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Eide

1981

Histopathology

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“…[9] On the other hand, other reports indicate that the main cause of the skin darkening is melanin precursors which are liberated into the bloodstream during the rapid lysis of MM metastatic tumors in the internal organs, a phenomenon triggered by anticancer therapy. [3,6,10] Subsequently, in the dermis and urine melanin, precursors undergo spontaneous oxidation and are transformed into the melanin. This theory has been supported by the documented observations of melanin precursors, melanin, melanosomes, and melanophages in patients’ serum.…”

Section: Discussionmentioning

confidence: 99%

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Maj

Jankowska‐Konsur²,

Gruber³

et al. 2017

Medicine

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Rationale:Diffuse melanosis cutis (DMC) is a very rare sign of malignant melanoma progression. The condition usually develops after approximately one year from melanoma diagnosis in a patient with metastatic tumors and after anticancer treatment with cytostatic medications.Patient concerns:A 72-year old Caucasian man was admitted to the Department of Dermatology with DMC for 4 months and the history of two melanomas treated surgically 30 years and 9 months before present hospitalization.Diagnosis:Histological and immunohistochemical examinations of DMC biopsy indicated melanoma metastatic cells as well as free deposits of melanin and melanophage presence in the dermis.Interventions:The patient refused to the treatment.Outcomes:The patient died eight months after DMC appeared.Lessons:DMC is a rare presentation of advanced MM and is a bad prognostic factor. The pathomechanisms of the discoloration of the skin are not fully explained. The role of micrometastases, as well as melanin precursors, released during lysis of MM metastases, and growth factors may play a role in the development of the symptom.

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Generalized melanosis complicating disseminated malignant melanoma in pregnancy: A case report

Holcomb

Thigpen

Puckett

et al. 1975

Cancer

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A case of generalized melanosis complicating disseminated malignant melanoma in pregnancy is described. Four features of this case, unique in combination, are discussed. First, generalized melanosis is a rare complication in macrophages of skin and other areas. Secondly, extensive bone lesions in the absence of roentgenographic changes are an uncommon occurrence. Thirdly, pregnancy probably has little effect on the course of melanoma, as illustrated by this case and a review of the literature. Finally, placental metastases may be more common than generally thought, yet may have little significance to the fetus.

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Malignant melanoma with melanosis and melanuria, and with pigmented monocytes and tumour cells in the blood. Autoradiographic demonstration of tyrosinase in malignant cells from peritoneal fluid

Cited by 25 publications

References 13 publications

Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Pathogenesis of generalized melanosis with melanuria and melanoptysis secondary to malignant melanoma

Diffuse melanosis cutis related to dermal micrometastases as the first clinical symptom of distant metastatic malignant melanoma

Generalized melanosis complicating disseminated malignant melanoma in pregnancy: A case report

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