Malignant melanoma with cavitary pulmonary metastasis: Diagnostic dilemma resolved by FDG PET/CT guided biopsy

Chakraborty, Partha Sarathi; Dhull, Varun Singh; Karunanithi, Sellam; Verma, Satyavrat; Kumar, Rakesh

doi:10.4103/0972-3919.136604

Cited by 4 publications

(1 citation statement)

References 8 publications

(9 reference statements)

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“…Recent studies have reported that FDG‐PET‐CT can successfully detect metastatic lesions of MM, which show false negative findings with CT and may be a valuable diagnostic tool for restaging and management of recurred MM 9, 10. Specifically, a number of recent reports have described PET/CT scan images of MM in the lung from the skin as lesions with increased uptake of the radiotracer 11, 12. However, information on primary MM of the lung (not metastatic) is still limited.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary malignant melanoma with distant metastasis assessed by positron emission tomography‐computed tomography

et al. 2016

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Melanoma is a cutaneous malignant neoplasm of melanocytes. Primary malignant melanoma (MM) of the lung is very rare. Although previous reports have described the radiologic features of pulmonary MM, its rarity means that many factors are unknown. Thus, radiologic diagnosis is very difficult. Furthermore, there is little information regarding diagnostic application and/or the usefulness of [18F]‐fluorine‐2‐fluoro‐2‐deoxy‐D‐glucose positron emission tomography‐computed tomography (FDG‐PET‐CT) for primary pulmonary MM. A 69‐year‐old patient with a productive cough lasting three weeks was admitted to our hospital. Chest CT showed a large single mass with a multi‐lobulated margin and homogeneous enhancement in the right upper lobe, which was subsequently diagnosed as a primary pulmonary MM with multiple metastases. On PET‐CT images, the pulmonary mass and multiple bone lesions showed very increased uptakes of FDG. Considering that pulmonary metastasis from a mucocutaneous melanoma is the main differential diagnosis of primary pulmonary MM, systemic assessment of the whole body is more important than for other types of lung malignancies. This report introduces PET‐CT as a useful diagnostic modality for pulmonary MM, especially in cases of distant multiple metastases.

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Section: Discussionmentioning

confidence: 99%

Pulmonary malignant melanoma with distant metastasis assessed by positron emission tomography‐computed tomography

et al. 2016

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18F-FDG-Directed Surgery and 18F-FDG-Directed Interventional Procedures

Povoski

Murrey

Hall

2016

Radioguided Surgery

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CT-Staging kutaner maligner Melanome

Hoffend

2015

Radiologe

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Malignant melanomas are a challenge in radiological imaging diagnostics as they may metastasize into every organ and tissue. Cross-sectional imaging, in particular positron emission tomography computed tomography (PET/CT) and whole body magnetic resonance imaging (MRI), are considered the standards in the staging of melanomas. Because of its excellent availability CT, however, remains a widely employed staging modality. Familiarity with the manifold CT morphology of metastasized melanomas as it is described here is essential when interpreting dedicated CT and in addition useful when interpreting PET/CT results. In individual cases CT can assist in the detection of transient metastases. In the detection of locoregional lymph node metastases CT has a median sensitivity and specificity in meta-analyses of at best 61 % and 97 %, respectively, which is inferior to the performance of ultrasound (96 % and 99 %, respectively). According to meta-analyses, in the assessment of systemic tumor spread CT can detect the majority of metastases with a sensitivity and specificity of 51-63 % and 69-78 %, respectively, which is inferior to MRI and PET/CT. Therefore, if an exact staging is required for critical management decisions, MRI or PET/CT should be employed whenever possible.

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Malignant melanoma with cavitary pulmonary metastasis: Diagnostic dilemma resolved by FDG PET/CT guided biopsy

Cited by 4 publications

References 8 publications

Pulmonary malignant melanoma with distant metastasis assessed by positron emission tomography‐computed tomography

Pulmonary malignant melanoma with distant metastasis assessed by positron emission tomography‐computed tomography

18F-FDG-Directed Surgery and 18F-FDG-Directed Interventional Procedures

CT-Staging kutaner maligner Melanome

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