Malignant Melanoma: Some Aspects of Pathology and Prognosis

Ironside, Philip; Pitt, Tracy; Rank, B. K.

doi:10.1111/j.1445-2197.1977.tb03938.x

Cited by 28 publications

(10 citation statements)

References 3 publications

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“…Studies examining the prognosis of regressed, transected tumors resulting from incomplete excision are lacking. Our results validate age, sex, Breslow's thickness, ulceration, and SLN status as prognostic factors for melanoma, and imply that transection, and moreover, lack of visible tumor after transection of a melanoma, do not affect patient survival. Conventional thinking would suggest that positive deep margins are a serious problem, preventing accurate staging.…”

Section: Discussionsupporting

confidence: 72%

Prognosis of Patients with Transected Melanomas

Martires

Nandi

Honda

et al. 2013

Dermatologic Surgery

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Section: Discussionsupporting

confidence: 72%

Prognosis of Patients with Transected Melanomas

Martires

Nandi

Honda

et al. 2013

Dermatologic Surgery

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“…In large series of the literature [9,12,14,15,17,19,21,27], the overall sex distribution of malignant melanoma of the skin shows a distinct pre ponderance of females over males, as in the present study.…”

Section: Discussionsupporting

confidence: 49%

“…Females, as a rule, show by far better survival ra tes than males, and the differences afier a few years of follow-up range be tween 8 and 20% [12,22,25,26], In comparison with the literature [2,6,18,19], the present study yields relatively lower overall survival rates for both sexes. This is certainly due to our patient material solely evaluated according to invasive malignant melanomas.…”

Section: Discussionmentioning

confidence: 45%

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8-Year-Survival in Malignant Melanoma Related to Sex and Tumor Location

Weidner¹

1981

Dermatology

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1,322 melanoma patients in the clinical stage I were followed up for at least 8 years. The females clearly predominated (sex ratio f :m = 2.2:1). Trunk melanomas prevailed in males and extremity melanomas in females. The overall survival was strikingly better in females than in males. In 936 of the patients exhibiting ‘high risk’ melanomas, tumors located on the upper extremities and on the lower extremities gave the relatively best 8-year-survival rates (60.7% resp. 62.7%). 8-year-survival rates decreased if head (52.8%) and trunk locations (40.3%) were involved. As to these anatomic sites of the primary tumor, there were no statistically relevant differences between the survival rates of the females and the males. Thus, the anatomic site of malignant melanoma is especially important for the prognosis largely explaining the sex differences of the overall survival rates.

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“…Epstein et al found a more favorable ten-year OS in the biopsy group (65%) as compared to the primary wide excision group (56%) but biopsy was loosely defined as less than optimal or complete surgical excision 9. Ironside et al found a five-year OS rate of 66% in the excision- and 43% in the incision biopsy group but failed to describe the distribution of prognostic factors between both groups 10. Rampen et al also found a worse prognosis for patients after an incision biopsy (14 patients) but the study was small and retrospective 11.…”

Section: Discussionmentioning

confidence: 99%

Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival

et al. 2007

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Background: In fair-skinned Caucasian populations both the incidence and mortality rates of cutaneous melanoma have been increasing over the past decades. With adjuvant therapies still being under investigation, early detection is the only way to improve melanoma patient survival. The influence of incisional biopsies on melanoma patient survival has been discussed for many years. This study investigates both the influence of diagnostic biopsy type and the presence of residual tumor cells in the re-excision specimen on disease free and overall survival.Methods: After (partial) removal of a pigmented skin lesion 471 patients were diagnosed with stage I/II melanoma and underwent re-excision and a sentinel node biopsy. All patients were followed prospectively, mean follow up >5 years. Patients were divided according to their diagnostic biopsy type (wide excision biopsy, narrow excision biopsy, excision biopsy with positive margins and incisional biopsy) and the presence of residual tumor cells in their re-excision specimen. Survival analysis was done using CoxÕs proportional hazard model adjusted for eight important confounders of melanoma patient survival.Results: The diagnostic biopsy was wide in 279 patients, narrow in 109 patients, 52 patients underwent an excision biopsy with positive margins and 31 patients an incisional biopsy. In 41 patients residual tumor cells were present in the re-excision specimen. Both the diagnostic biopsy type and the presence of tumor cells in the re-excision specimen did not influence disease free and overall survival of melanoma patients.Conclusions: Non-radical diagnostic biopsies do not negatively influence melanoma patient survival.

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Malignant Melanoma: Some Aspects of Pathology and Prognosis

Cited by 28 publications

References 3 publications

Prognosis of Patients with Transected Melanomas

Prognosis of Patients with Transected Melanomas

8-Year-Survival in Malignant Melanoma Related to Sex and Tumor Location

Non-Radical Diagnostic Biopsies Do Not Negatively Influence Melanoma Patient Survival

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