Malignant melanoma presenting as a unilateral ovarian neoplasm

Hsiu, Jeng-Gwang; Kemp, George M.; Given, Fred T.; D'Amato, Nicholas A.

doi:10.1016/0090-8258(86)90314-8

Cited by 8 publications

(6 citation statements)

References 9 publications

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“…Despite thorough examination and a positron emission tomography scan, the primary tumor site was not evident in this case. Spontaneous regression of the primary lesion may have occurred 3 . Ovarian metastasis from a regressed melanoma has been reported by Martinelli et al 11…”

Section: Discussionmentioning

confidence: 88%

“…The majority of these neoplasms are thought to originate in a cystic teratoma and are regarded as one of the rarest types of malignant transformation in cystic teratoma 1 . Ovarian melanoma without evidence of teratoma should be considered metastatic because the ovary does not have melanin producing cells 2,3 . To date, seven cases of ovarian melanoma without evidence of teratoma have been reported 3–9 …”

Section: Introductionmentioning

confidence: 99%

“…Ovarian melanoma without evidence of teratoma should be considered metastatic because the ovary does not have melanin producing cells 2,3 . To date, seven cases of ovarian melanoma without evidence of teratoma have been reported 3–9 …”

Section: Introductionmentioning

confidence: 99%

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Ovarian malignant melanoma without evidence of teratoma

Lee¹,

Lee²,

Shin³

et al. 2010

J of Obstet and Gynaecol

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A 46-year-old woman with ovarian malignant melanoma had advanced intraperitoneal metastasis, retroperitoneal and inguinal lymph node metastases. Extensive debulking surgery was performed and chemotherapy was given. Microscopically, no evidence of other accompanying tumor, such as teratoma was noted. Detailed examination of the patient failed to identify any evidence of another primary melanoma site. It is assumed that spontaneous regression of the primary lesion occurred. Despite the surgery and chemotherapy, the patient died within 2 months of diagnosis. Considering this case, it is assumed that the combination of surgical debulking and chemotherapy are not always beneficial in ovarian malignant melanoma and the prognosis of ovarian malignant melanoma is very poor.

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Section: Discussionmentioning

confidence: 88%

Section: Introductionmentioning

confidence: 99%

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Ovarian malignant melanoma without evidence of teratoma

Lee¹,

Lee²,

Shin³

et al. 2010

J of Obstet and Gynaecol

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“…The chemotherapy regimens used varied but, with one exception (28) , involved combination regimens, all including cisplatin. Four of the six patients showed no evidence of disease 12 or more months after treatment (Table 1), while two (16,20) had died, 2 and 8.5 months, respectively, after presentation. Two patients (21,28) relapsed after adjuvant chemotherapy but responded to further chemotherapy.…”

Section: Discussionmentioning

confidence: 98%

“…A variety of other tumors can occur, including fibrosarcoma, leiomyosarcoma, osteosarcoma, basal cell carcinomas, and melanoma. Primary ovarian malignant melanoma was first reported in 1901 (2) , with 30 cases reported in the world literature to date (2−30) . The median age of the previously reported cases was 49 years (range 20–87 years).…”

mentioning

confidence: 99%

Metastatic malignant melanoma arising in a mature ovarian cystic teratoma: a case report and literature review

McNeilage

Morgan

Constable

et al. 2005

Int J Gynecol Cancer

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Primary malignant melanoma arising inform the ovary is rare, with only 30 cases described in the literature to date. The case reported here occurred in a 19-year-old woman and was rapidly progressive, resulting in death only 37 days following initial presentation. Management of this case is discussed in the context of the other reported cases. Surgery, ranging from an ovarian cystectomy to a radical debulking procedure, has been the main treatment with adjuvant chemotherapy utilized in only 4 of the previous cases. Key problems in management relate to the ability to make the diagnosis at the time of surgery and the overall poor response rates of melanoma to adjuvant chemotherapy.

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