Malignant Melanoma Originating in the Thymus

Shimizu, Junzo; Kawaura, Yukimitsu; Tatsuzawa, Yasuhiko; Kinoshita, Takahiro; Nozaki, Zensei; Ohta, Yasuhiko; Nonomura, Akitaka

doi:10.1046/j.1440-1622.2000.01952.x

Cited by 6 publications

(2 citation statements)

References 7 publications

(2 reference statements)

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“…primary malignant melanoma of the anterior mediastinal region is extremely rare, with fewer than 10 cases having been reported so far [2,3]. among them, three cases were reported as primary thymic malignant melanomas [4].…”

Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the thymus: report of a case

et al. 2014

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A 61-year-old male was admitted to our hospital complaining of bloody sputum. A chest roentgenogram revealed a clearly demarcated mass located in the anterior mediastinum. Positron emission tomography revealed abnormal accumulation of (18)F-fluorodeoxy glucose only in the anterior mediastinal tumor. A computed tomography-guided needle aspiration biopsy was performed, and the tumor was diagnosed as a malignant melanoma. Although the skin, eyeballs, oral cavity, nasal cavity, etc., were closely evaluated, no other lesion of malignant melanoma was detected except the mediastinal tumor. Hence, this tumor was diagnosed as a primary malignant melanoma. We performed total thymectomy, including the tumor, and combined resection of the adhesive bilateral lungs, pericardium and left brachiocephalic vein. Because the tumor was histologically surrounded by thymus tissue, we diagnosed it as a primary mediastinal malignant melanoma that originated in the thymus. Although the patient's postoperative course was uneventful, he complained of back pain 5 months after the operation. Multiple bone metastases were found, and he received chemotherapy and radiotherapy, and is currently alive with disease 14 months after the primary treatment.

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Section: Discussionmentioning

confidence: 99%

Primary malignant melanoma of the thymus: report of a case

et al. 2014

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“…On the other hand, other studies and evidence suggest that melanomas primarily diagnosed in unusual visceral locations are metastases of melanomas of unknown origin, probably from completely regressed or misdiagnosed skin melanoma [ 4 ]. The thymus is an exceptional localization of melanoma, with fewer than ten primary intrathymic melanomas and only one report of intrathymic metastasis described in the literature [ 5 , 6 , 7 , 8 , 9 , 10 , 11 ]. We present two cases of thymic localization of melanoma misdiagnosed as a primary thymic tumor by clinicians and that were subjected to surgery.…”

Section: Introductionmentioning

confidence: 99%

Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature

et al. 2023

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Intrathymic localizations of melanoma represent a very rare entity, with fewer than ten cases of intrathymic melanoma described in the literature. Herein, we describe two cases of patients who underwent surgical removal of a thymic mass at our thoracic surgery department between 2015 and 2022. The final pathological examination revealed a malignant melanoma in both cases; we therefore carried out a literature review to identify such rare and similar cases. In the first case, the intrathymic localization of melanoma was the first manifestation of the disease, posing a dilemma regarding the metastatic and primitive nature of the neoplasm. The second case described a thymic metastasis from a known previous cutaneous melanoma, for which the patient had successfully been treated six years earlier. After carefully reviewing the literature, we identified only six cases of verified primary intrathymic melanomas and one case of intrathymic metastasis resulting from melanoma previously described. Pathologists should be aware of the occurrence of this rare entity and mindful of the differential diagnoses. Several tools, including immunostaining of melanocytic markers and molecular investigations, are mandatory for final pathological diagnosis.

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BRCA1 Gene Mutation in Thymic Malignant Melanoma

Park

Lee

et al. 2013

The Annals of Thoracic Surgery

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Malignant Melanoma Originating in the Thymus

Cited by 6 publications

References 7 publications

Primary malignant melanoma of the thymus: report of a case

Primary malignant melanoma of the thymus: report of a case

Intrathymic Localization of Melanoma: A Brief Report of Two Cases and a Review of the Literature

BRCA1 Gene Mutation in Thymic Malignant Melanoma

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