Malignant melanoma of the third eyelid in a horse

Albanese, Valeria; Newton, Joseph C.; Waguespack, Richard W.

doi:10.1111/eve.12012

Cited by 14 publications

(13 citation statements)

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“…For this reason, the decision was made to perform an excisional biopsy associated with cryotherapy. Reports of the treatment of adnexal melanomas in horses are rare [1,6]. In the treatment of melanoma located on the human conjunctiva, the gold standard is wide surgical excision and cryotherapy to the margins [2,3].…”

Section: Discussionmentioning

confidence: 99%

“…These tumors are found most frequently in the perineal area, the external genitalia, the ventral surface of the tail and the parotid region [10]. Melanomas occur frequently in grey horses after the age of 5 years [1]. Ocular melanomas are uncommon in comparison to cutaneous tumors in horses [6].…”

Section: Introductionmentioning

confidence: 99%

“…In humans, treatment options for conjunctival melanoma include surgical excision, excision associated with cryotherapy, radiotherapy, and chemotherapy [2]. Melanomas located in the orbit, ocular adnexa, epibulbar area, or intraocular have been reported in horses [1,5]. However, a review of the literature reveals only a single documented case of melanoma located in the conjunctiva of a horse [6].…”

Section: Introductionmentioning

confidence: 99%

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Conjunctival Melanoma in a Horse Treated by Tumor Resection and Cryotherapy

Pigatto

Vargas

Torikachvili

et al. 2018

Acta Scientiae. Vet.

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Background: Ocular melanoma is very rare compared to cutaneous melanoma in horses. Definitive diagnosis is made through histopathological examination and treatment options include surgical excision associated with cryotherapy, radiation therapy, and chemotherapy. In this report, we describe a case of conjunctival melanoma in a horse that has been treated successfully with surgical excision associated with cryotherapy. Case: A 15-year-old male Percheron male was referred to the Ophthalmology Veterinary Section of the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil, with a history of a pigmented mass located on the lower eyelid of the left eye. Ophthalmologic examination revealed ocular discomfort, secretion and a pigmented mass in the left inferior bulbar conjunctiva. The dermatological examination revealed other melanomas in the perineal region. Complete blood count and serum chemistry profile were within normal ranges and prior to surgery the horse was treated with flunixin meglumine (1.1 mg/kg, IV, q 12 h). Sedation was performed with xylazine (0.4 mg/kg, IV) and detomidine hydrochloride (0.01 mg/kg, IV) and then the animal was placed in a retention trunk. The conjunctival mass was resected with a margin of safety. Liquid nitrogen was applied to the tumor site and the adjacent conjunctiva with a copper cryoprobe with one unit of liquid nitrogen. Histopathological examination revealed neoplastic cells containing pigmented melanocytes in the conjunctival submucosa, confirming the diagnosis of conjunctival melanoma. Postoperative treatment was performed with flunixin meglumine (1.1 mg/kg, IV, q 12 h) for 3 days and topical ophthalmic ointment containing neomycin, polymyxin B sulfate and dexamethasone twice daily for one week. Seven days after surgery, the lesion was healed. The patient was followed for 24 months after excision and there was no evidence of recurrence. Discussion: Older horses are considered more predisposed to melanoma development, possibly because of the proliferation of melanocytes as a manifestation of aging, and in addition, cutaneous melanomas are common in gray horses and rare in other horse colors. In this case, the horse was a 15-year-old Percheron horse with gray hair. In horses, there is only one case of conjunctival melanoma documented in the literature. In both cases, the ophthalmic examination revealed a large, raised, heavily pigmented mass protruding from the bulbar conjunctiva. The only difference is that in the present case the location of the mass was in the inferior bulbar conjunctiva and in the case cited in the literature. The mass was located in the bulbar conjunctiva under the lateral comer. In this case, the diagnosis of conjunctive melanoma was based on clinical signs and confirmed by histopathological examination. It was decided to perform an excisional biopsy for treatment and to confirm the diagnosis of conjunctival melanoma. The choice of treatment depends very much on the clinical presentation, that in this animal, despite the neoplasia being exte...

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Conjunctival Melanoma in a Horse Treated by Tumor Resection and Cryotherapy

Pigatto

Vargas

Torikachvili

et al. 2018

Acta Scientiae. Vet.

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“…Eine Therapie mit Cimetedin (mit antitumoröser Wirkung) über einen langen Zeitraum ist eine günstige Alternative [7]. Es gibt aber keine Studie über die schrumpfende Wirkung von Cimetedin auf uveale Melanome [4] und die Wirkung ist umstritten [1,2]. Das empfohlene Schema ist, 2,5 mg/kg Körpergewicht alle 8 Stunden über 2 Wochen, danach Dosisreduzierung auf 1-0,5 mg/kg Körpergewicht, diese Dosis wird über Monate weitergegeben [7].…”

Section: Therapieunclassified

Der klinische Fall: Intraokulares Melanom bei einer Ponystute

Einhellig¹,

Bartke²,

Herder³

2019

pferde spiegel

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“…), retrobulbar space (Sweeney and Beech ) , the third and lower eyelids (Rizk ; Albanese et al . ), foot (Honnas et al . ; Floyd ), vertebrae (Traver et al .…”

Section: Introductionmentioning

confidence: 99%

Unilateral malignant melanoma of the adrenal gland with metastatic spread to the thorax in a horse

Hablolvarid

2018

Equine Veterinary Education

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A 7-year-old grey horse that had a history of inappetence, weight loss, weakness, dyspnoea, coughing and intermittent colic was examined post-mortem. A melanoma, confirmed histologically, was found in the right adrenal gland and had eroded into the posterior vena cava. Thoracic metastases were also identified. The skin, including the legs, trunk and perineum was normal with no evidence of melanomas. This was considered to be a primary, malignant melanoma, a novel finding in the adrenal gland of the horse.

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Malignant melanoma of the third eyelid in a horse

Cited by 14 publications

References 50 publications

Conjunctival Melanoma in a Horse Treated by Tumor Resection and Cryotherapy

Conjunctival Melanoma in a Horse Treated by Tumor Resection and Cryotherapy

Der klinische Fall: Intraokulares Melanom bei einer Ponystute

Unilateral malignant melanoma of the adrenal gland with metastatic spread to the thorax in a horse

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