Malignant melanoma of the skin: prognostic value of clinical features and the role of treatment in 111 cases

Repeated equally effective suberythemogenic exposures to ultraviolet (UV)A1 or narrowband UVB induce similar changes of the dermoscopic pattern of acquired melanocytic nevi that can be prevented by high-protection UVA-UVB sunscreens

“…They are activated by suberythemogenic exposures to UVB or UVA1 [16][17][18] but an increase in number can be observed only after UVB, but not UVA1 overexposures. 16 A high proportion (57%-85%) of melanomas develop within pre-existing nevi, [19][20][21] and nevi that undergo malignant changes may result in melanomas that are thicker and, as a consequence, have potentially a poorer prognosis compared with de novo melanomas. 22 The main question to be addressed is whether activation of photoexposed melanocytes in AMN is caused by cell damage that would be relevant to the induction, promotion, or progression of a melanoma within an AMN.…”

A study of the influence of various diagnostic and therapeutic procedures applied to a murine squamous carcinoma on its metastatic behaviour

“…In the case of malignant melanomata, radical excision is usually performed on the basis of a clinical diagnosis, for fear of increasing the risk of metastases. However, the evidence to support such a policy is tenuous: Jones et al (1968) and Epstein, Bragg and Linden (1969) both found no evidence of an adverse prognosis in patients whose malignant melanomata were biopsied or locally excised before more radical treatment.…”

Malignant Melanoma: A Review

“…Jones Williams et al (1968) reviewing the five‐year survival rate of 89 patients with malignant melanoma found that depth of involvement and the number of mitoses (if greater than one per five high‐power fields) were the only features that were of prognostic value.…”