Malignant Melanoma of the Penis

Abstract

Malignant melanoma of the penis is rare and accounts for only a small percentage of penile carcinomas. We report the largest series and the longest followup of patients with this disease. The tumor usually presents as a small, brown or black lesion, often ulcerating, on the glans penis. Stage I disease (confined to the penis) can be treated conservatively by distal penectomy and results in excellent survival. Palpable inguinal lymph nodes and nodes associated with thick cutaneous lesions require surgical exploration. Stages II (node positive) and III (metastatic) diseases carry a poor prognosis, mainly because of the lack of effective adjuvant systemic therapy.

Penile malignant melanoma in a hemodialysis patient

“…Fifty-five percent of cases of penile malignant melanoma occur in the glans penis 3 and appear in an older age population than malignant melanomas in general. 3,4 Patients with malignant melanoma of stage III or more have an extremely poor prognosis; the 5-year and 10-year survival rates of Japanese patients with stage IIIB melanoma are 40% and 38%, respectively.…”

“…3,4 Patients with malignant melanoma of stage III or more have an extremely poor prognosis; the 5-year and 10-year survival rates of Japanese patients with stage IIIB melanoma are 40% and 38%, respectively. 5 Penile malignant melanoma patients with positive lymph nodes carry a poor prognosis of less than 2 years of mean survival.…”

“…5 Penile malignant melanoma patients with positive lymph nodes carry a poor prognosis of less than 2 years of mean survival. 3 According to the guidelines for treatment of patients in each stage, in addition to radical dissection of regional lymph nodes, DAVFeron therapy is recommended as a postoperative adjuvant chemotherapy for patients with stage III melanoma. 5 The DAV therapy, which is a three-drug combination therapy with DTIC, ACNU and VCR, is a typical chemotherapy regimen for malignant melanoma in Japan.…”

Malignant Melanoma in Genito-Urinary Tract

“…Considering the rarity of the disease, aggressive treatment in selected patients with penectomy or partial penectomy of the primary tumor with bilateral lymph node dissection has been recommended. 65 Despite aggressive surgical treatment and chemotherapy, patients with metastatic disease have a poor prognosis. Patients with penile melanoma of stage III or more have an extremely poor prognosis; the 5 year and 10 year survival rates of Japanese patients with stage IIIB melanoma are 40% and 38%, respectively.…”

Melanoma de pene

“…Nos inclinamos por la linfadenectomía bilateral, sin ningún otro tipo de tratamiento complementario. Los estadios II con ganglios linfá-ticos positivos y III con metástasis a distancia precisaran de otros tipos de tratamiento complementario radio, quimio o inmunoterapia según protocolos [5][6][7] .…”