Malignant Melanoma of the Foot

Søndergaard, Knud; Olsen, Grete

doi:10.1111/j.1699-0463.1980.tb02497.x

Acta Pathologica Microbiologica Scandinavica Section A Patholog

1980

DOI: 10.1111/j.1699-0463.1980.tb02497.x

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Malignant Melanoma of the Foot

Knud Søndergaard¹,

Grete Olsen²

Abstract: In a retrospective study of 125 primary cutaneous malignant melanomas of the foot treated from 1949 to 1977 the prognostic importance of various histological and clinical factors was observed. Clinical stage, location of tumour on the foot, level of invasion, tumour thickness, mitotic rate, and presence of ulceration correlated well with survival, while sex and histological type did not. A histological transition was found between the superficial spreading type and the acral lentiginous type, indicating a clos… Show more

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1982

1985

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Cited by 5 publications

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Histological type and biological behavior of primary cutaneous malignant melanoma

Søndergaard

1983

Vichows Archiv A Pathol Anat

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Primary cutaneous malignant melanomas are generally divided into 3 separate clinico-pathological variants, lentigo maligna melanoma (LMM), superficial spreading melanoma (SSM), and nodular melanoma (NM). Recently an additional variant, acral lentiginous melanoma (ALM), has been defined, occurring on acral regions, defined as plantar, palmar, and sub-/parungual areas. Histological examination of 86 primary melanomas on acral regions revealed 24 (28%) acral lentiginous melanomas (ALM), 23 (27%) superficial spreading melanomas (SSM), 18 (21%) nodular melanomas (NM), and 21 (24%) unclassifiable melanomas. No LMM was seen. The prognosis was found to be the same in patients with SSM and ALM. However, by correlating histological type with frequency of antecedent nevus, duration of melanoma and dominant invasive tumor cell, it was demonstrated that histologically typical ALM differed from histologically typical SSM by their infrequent origin from antecedent nevi, their lower local growth rate, and their more frequent content of spindle cells. These findings support ALM as a valid melanoma subtype only when clearly defined histologically.

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Histological type and biological behavior of primary cutaneous malignant melanoma

Søndergaard

1983

Vichows Archiv A Pathol Anat

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Survival with primary cutaneous malignant melanoma, evaluated from 2012 cases

Søndergaard

Schou

1985

Vichows Archiv A Pathol Anat

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Cox's multivariate regression model for survival data was applied to 2,012 patients with primary cutaneous melanoma in order to evaluate the relative prognostic value of numerous clinical and histological variables and to establish their prognostically most efficient combination. The material was divided into 4 groups according to the size of resection margin of the primary lesion (less than 2.0 cm, 2.0 cm, 2.1-4.9 cm, and greater than or equal to 5.0 cm). Data were analysed separately in these 4 groups and equivalent results were obtained. The risk factors were clinical stage, site of tumour, tumour thickness, level of invasion, mitotic activity, ulceration, lymphocytic reaction, predominant type of invasive tumour cell and partial regression. When accounting for these factors, histological type, nuclear pleomorphism, nucleolar size, vascular invasion, pigmentation, verrucous growth pattern, and dermal elastosis were without prognostic influence. The effect of sex and age of patient was uncertain and both variables, therefore, were retained in the model. By using Cox's method it is possible to make a qualified estimate of the survival for the individual patient.

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Acral lentiginous melanoma: an illustrative case report and brief review of the literature

Ward

Breach

Hall-Smith

1984

British Journal of Plastic Surgery

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Malignant Melanoma of the Foot

Cited by 5 publications

References 16 publications

Histological type and biological behavior of primary cutaneous malignant melanoma

Histological type and biological behavior of primary cutaneous malignant melanoma

Survival with primary cutaneous malignant melanoma, evaluated from 2012 cases

Acral lentiginous melanoma: an illustrative case report and brief review of the literature

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