Malignant Melanoma of the Eyelid and Conjunctiva

Collin, J. R. O.; Allen, L. H.; Garner, A; Hungerford, J. L.

doi:10.1111/j.1442-9071.1986.tb00004.x

Cited by 25 publications

(6 citation statements)

References 9 publications

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“…Several authors have reviewed the clinical3-5 [17][18][19] and histopathological-" 13 152021 features of conjunctival melanoma and these studies have advanced our understanding of pigmented lesions of the conjunctiva. However, there is still uncertainty regarding clinical and pathological prognostic factors associated with conjunctival melanoma.…”

Section: Discussionmentioning

confidence: 99%

Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases.

Potter

Shields

et al. 1993

British Journal of Ophthalmology

127

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ResultsThere were 68 patients with conjunctival melanoma who were evaluated and treated: all were white. Of the 68 conjunctival melanomas, 37 (54%) involved the right eye, 31 (46%) the left eye, and none were bilateral. The tumour either appeared as a new conjunctival lesion or a change (increase in pigmentation or size) in a previously static conjunctival lesion as noted by the patient or the ophthalmologist. The mean follow up was 7-5 years (range 0F4-28-3 years; median, 6-8 years).Among the 68 patients with conjunctival melanoma there were 43 patients (65%) who were treated initially at another institution and referred to us for evaluation and further treatment because of the histopathological diagnosis of conjunctival melanoma. Twenty five patients (35%) were evaluated and treated initially at our institution by us using our standard techniques. 16 To ensure that there was no bias in our analysis, we elected to evaluate this subgroup of 25 patients separately in order to determine the clinical parameters that were significantly associated with local recurrence and metastasis and compare this with the total group of 68 patients.The presumed origin of the conjunctival 624 on 11 May 2018 by guest. Protected by copyright.

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Section: Discussionmentioning

confidence: 99%

Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases.

Potter

Shields

et al. 1993

British Journal of Ophthalmology

127

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“…The reported incidence of choroidal melanomas has increased in recent decades, possibly because of greater exposure to UV light ( 2 ), or possibly due to greater detection. Eyelid melanomas are very rare, with knowledge limited to small case series ( 3 – 5 ).…”

Section: Introductionmentioning

confidence: 99%

Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients

Rose

Luthert²,

Jayasena

et al. 2017

Front. Oncol.

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BackgroundPeriocular melanoma is a rare but often deadly malignancy that arises in the uvea (commonest origin), conjunctiva or orbit (rarest primary site). Melanoma accounts for 5–10% of metastatic/secondary orbital malignancies, but only a tiny proportion of primary orbital neoplasia. Primary orbital melanoma (POM) is exceedingly rare, with approximately 50 cases reported to date.MethodsAll patients seen in the orbital unit at a tertiary referral hospital (1991–2016) with a biopsy-proven diagnosis of POM were identified from a diagnostic database and were studied. The case notes, imaging, surgical approach, and histology were reviewed.ResultsThirteen patients (five male; 38%) presented with isolated malignant melanoma of the orbit, for which no other primary site was identified at presentation or during an average follow-up of 44 months (median 22; range 0–13 years). The patients presented between the ages of 40 and 84 years (mean 55.5; median 48 years) and typically gave a short history of rapidly increasing proptosis and eyelid swelling. On the basis of history, a malignant lesion was suspected in most patients and all underwent incisional biopsy, with debulking of the mass in 10 (77%) patients, and skin-sparing exenteration in 3/13 (23%). Ten patients underwent orbital radiotherapy and the survival to date ranged from 9 months to 14 years (mean 55 months; median 23 months); two patients received solely palliative care for widespread disease and one patient refused orbital radiotherapy. Five of the 13 (38%) patients died from the disease.DiscussionPOM is a very rare malignancy, but clinical analysis of this cohort gives insight into disease presentation and prognosis. The tumor typically presents with a rapidly progressive, well-defined mass that is, in some cases, amenable to macroscopically intact excision. Unusual for malignant melanoma, some of these patients can show an unusually long period of quiescent disease after surgical debulking and radiotherapy.

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“…The decisive diagnosis procedure in conjunctival melanoma is the histological examination [ 1 , 2 , 3 , 4 ]. Dermoscopy is a noninvasive technique that can help us to distinguish between benign and malignant lesions.…”

Section: Discussionmentioning

confidence: 99%

Conjunctival Melanoma: A New Clinical and Therapeutical Approach

Rodríguez-Martín

Paz

et al. 2010

Case Rep Dermatol

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Melanoma involving the conjunctiva is extremely rare. Graver prognosis has been reported with primary conjunctival melanoma than with their cutaneous counterparts [Collin et al.: Aust N Z J Ophthalmol 1986;14:29–34]. Among conjunctival melanomas, two significant risk factors for tumour-related death have been identified: (i) age older than 55 years and (ii) unfavourable tumour location (caruncle, cornea, fornix, palpebral conjunctiva) [Werschnik and Lommatzsch: Am J Clin Oncol 2002;25:248–255]. Here we present a rare case of lentigo maligna involving the palpebral, bulbar conjunctiva and the caruncle. We describe dermoscopic patterns observed and the use of a novel ocular melanoma therapy with topical imiquimod.

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Malignant Melanoma of the Eyelid and Conjunctiva

Cited by 25 publications

References 9 publications

Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases.

Clinical predictive factors for development of recurrence and metastasis in conjunctival melanoma: a review of 68 cases.

Primary Orbital Melanoma: Presentation, Treatment, and Long-term Outcomes for 13 Patients

Conjunctival Melanoma: A New Clinical and Therapeutical Approach

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