Malignant Melanoma of the Breast: A Case Report and Review of the Literature

Tan, Marcus; Howard, Allison; Cyr, Amy

doi:10.1177/030089161309900125

Cited by 3 publications

(4 citation statements)

References 21 publications

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“…In a series of 1,362 patients with breast lesions seen in a single academic hospital, no melanomas were among the 23 nonepithelial tumors . Several cases of cutaneous melanomas on the skin overlying the breast have been published in the literature but only a few cases of primary noncutaneous (parenchymal) malignant melanoma of the breast have been reported. A Pubmed/ Medline search of case reports including a manual search of retrieved articles references has disclosed five case reports in the last 35 years (Table ).…”

Section: Discussionmentioning

confidence: 99%

Primary Noncutaneous Malignant Melanoma of the Breast

Rassouli

Voutsadakis

2016

Breast J

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Primary noncutaneous breast melanoma without an apparent skin primary lesion is uncommon. Its pathogenesis is debated with some authors believing that it is a metastatic disease from an undiscovered primary or a primary that has since completely regressed but it may be a true primary tumor arising from ectopic melanocytes. We present a case of a V600E BRAF mutation-positive primary noncutaneous breast melanoma diagnosed at an early stage in a screening mammogram as a solitary breast lesion without nodal involvement. Considerations of treatment of this rare disease are discussed.

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Section: Discussionmentioning

confidence: 99%

Primary Noncutaneous Malignant Melanoma of the Breast

Rassouli

Voutsadakis

2016

Breast J

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“…More often they are of metastatic origin. 12-15 It is hypothesized by Yen at al 11 in their case report in 2000 that some of the rare primary (parenchymal) breast melanomas may actually represent an “extreme” example of a metaplastic breast carcinoma with unidirectional differentiation toward a melanoma cell type.…”

Section: Discussionmentioning

confidence: 99%

“…However, removing clinically normal nodes has no proven therapeutic benefit, therefore a sentinel lymph node biopsy can be considered in the management of clinically node-negative patients, reducing the number of unnecessary lymph node dissections. 12,14,20,22…”

Section: Discussionmentioning

confidence: 99%

Phyllodes Tumor of the Breast With Malignant Melanoma Component

2015

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Phyllodes tumors of the breast display a wide variation in histological appearance and are classified into benign, borderline, and malignant categories based on a combination of histological parameters. These tumors may include a malignant heterologous component that is believed to originate through a process of multidirectional differentiation from a cancer stem cell. In these cases, the tumor is classified as a malignant phyllodes tumor. Among the heterologous elements that have been described in malignant phyllodes tumors are rhabdomyosarcoma, chondrosarcoma, osteosarcoma, liposarcoma and angiosarcoma. We present the first case of a phyllodes tumor with a malignant melanoma component in the breast of a 71-year-old lady, discussing the clinical implications of this diagnosis.

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“…Breast metastases from solid primary tumors are uncommon, with an incidence of 1.3% to 6.6% for all breast malignancies (1). Also primary breast melanoma is a very rare entity and can be mistaken for triple-negative breast cancer (2). About 20% of patients affected by malignant melanoma develop metastases; the commonest sites are liver, lung, and brain, while breast metastases are rare (1).…”

Section: Introductionmentioning

confidence: 99%