Malignant Melanoma Metastatic to Oligodendroglioma: Case Report and Literature Review of Tumor-to-Tumor Metastasis to Gliomas

Larsen, Alexandra Giantini; Grannan, Benjamin L.; Lee, Christine K.; Koch, Matthew J.; Williams, Erik A.; Frosch, Matthew P.; Cahill, Daniel P.

doi:10.1093/jnen/nly029

Cited by 4 publications

(1 citation statement)

References 31 publications

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“…TTM refers to the growth and spread of a primary malignant tumor into an existing tumor through blood vessels or lymphatic pathways (7). TTM typically occurs in immunocompromised patients, such as organ transplant recipients or those with HIV (8).…”

Section: Discussionmentioning

confidence: 99%

Case Report: Tumor-to-tumor metastasis with prostate cancer metastatic to lung cancer: the first reported case

Liu,

Li,

Dong

et al. 2023

Front. Oncol.

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Tumor-to-tumor metastasis (TTM) occurs rarely in tumor progression, but this event has significant clinical implications. Although the impact of TTM on patient prognosis and survival has been increasingly recognized, understanding of TTM biology and treatment is limited. Prostate cancer is among the most common malignancies threatening male health. Prostate cancer can potentially metastasize to primary lung Cancer; however, this is an exceedingly rare event. We here report for the first time a case of TTM from a prostate cancer to a coexisting primary lung cancer.

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Section: Discussionmentioning

confidence: 99%

Case Report: Tumor-to-tumor metastasis with prostate cancer metastatic to lung cancer: the first reported case

Liu,

Li,

Dong

et al. 2023

Front. Oncol.

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Glioblastoma with Probable Intratumoral Adenocarcinoma Metastasis: A Rare Report with Review of Literature

Goyal,

Rao,

Bhat

et al. 2024

Int J Surg Pathol

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“Tumor-to-tumor metastasis,” an uncommon phenomenon, refers to a primary tumor metastasis into another tumor, with the most frequent donor being lung carcinoma and common recipients being renal cell carcinoma and meningioma. Tumor-to-tumor metastasis occurring in gliomas is rare with less than 20 reports described so far, and that into a glioblastoma is even rarer. We report a 54-year man, diagnosed with glioblastoma, IDH-wildtype, with metastasis of an adenocarcinoma into it. On histomorphology, the glial component was composed of astrocytic cells and showed increased mitosis, microvascular proliferation, and focal necrosis. This was intermingled with an adenocarcinomatous tumor with pleomorphic epithelial cells in glands, nests, and sheets. On immunohistochemistry, the adenocarcinomatous areas were positive for AE1/AE3 and TTF1 but negative for glial markers, ruling out adenoid glioblastoma. Further cytogenetic analysis showed EGFR amplification in the glial component but not in the adenocarcinoma component, ruling out glioblastoma with true epithelial metaplasia, and supporting the diagnosis of adenocarcinoma metastasis into glioblastoma. Glioblastomas may be susceptible to intratumoral metastasis due to the proliferating leaky vascular channels, however, the short survival of patients with glioblastoma may be responsible for the rarity of this occurrence. The documentation of these tumors is important as they may be important for clinical diagnosis and further treatment and prognosis.

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Rare malignant skin tumours of the head and neck

Oroz

Bokun

Lazović

et al. 2018

Sanamed

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Introduction: Malignant skin tumors in the majority of cases arise from the squamous epithelium, although they may occur in other accompanying skin structures, such as skin adnexa (hair follicle, sweat and sebaceous glands), as well as soft tissues participating in the building of skin structure, such as muscles, fibrous, fatty tissue and cartilagå. Those tumors may also have a neuroendocrine origin or may arise from a premalignant lesion (solar keratosis and lentigo maligna). Regardless of their origin, they usually present as a nodule or longstanding, non-healing ulceration. Their early recognition enhances the treatment results and decreases the possibility of complications (invasion of deeper tissue structures and occurrence of regional and distant metastases). Material and methods: Our retrospective study included 100 patients of both sexes surgically treated for skin malignancy in the Department for Otorhinolaryngology and Maxillofacial surgery of the Clinical Hospital Centre "Zemun" , Belgrade, Serbia. The goal of this paper is to highlight the frequency of rare malignant tumors compared to the more frequent ones and consider the most appropriate clinical-diagnostic approach as well as the treatment modality for the patient. Conclusion: Our study has shown that the most frequent tumor of the head and neck skin is basal cell carcinoma.

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Malignant Melanoma Metastatic to Oligodendroglioma: Case Report and Literature Review of Tumor-to-Tumor Metastasis to Gliomas

Cited by 4 publications

References 31 publications

Case Report: Tumor-to-tumor metastasis with prostate cancer metastatic to lung cancer: the first reported case

Case Report: Tumor-to-tumor metastasis with prostate cancer metastatic to lung cancer: the first reported case

Glioblastoma with Probable Intratumoral Adenocarcinoma Metastasis: A Rare Report with Review of Literature

Rare malignant skin tumours of the head and neck

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