Malignant Melanoma in Pleural Effusion in a 14-Year-Old Cat

Morges, Michelle A.; Zaks, Karen

doi:10.1016/j.jfms.2011.05.011

Cited by 9 publications

(5 citation statements)

References 13 publications

(61 reference statements)

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“…7 Unlike canine species and human beings, melanocytic neoplasms are rare in cats. [8][9][10][11][12][13] The eye is the most commonly involved site and ocular melanomas are the most frequent intraocular tumours in cats. 10 Few data are available concerning non-ocular melanomas.…”

Section: Introductionmentioning

confidence: 99%

Non-ocular melanomas in cats: a retrospective study of 30 cases

Chamel

Abadie

Albaric

et al. 2016

Journal of Feline Medicine and Surgery

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Objectives The aim of the study was to describe the clinical outcome of 30 cats with non-ocular melanomas and to evaluate the association between clinical or pathological parameters and overall survival time. Methods The database of the animal histopathological laboratory of the National Veterinary School of Nantes (Oniris, Nantes, France) was retrospectively searched to identify cases of feline non-ocular melanomas between December 2009 and April 2014. For each case, clinical data, including signalment, location of the primary tumour, staging, treatment and outcome, were collected from the medical records or via interviews with referring veterinarians. Histological and immunohistochemical evaluation included mitotic index, cytonuclear atypias, junctional activity, Melan A and S100 immunostaining, and surgical margins. Univariate analysis to test the prognostic value of the different variables was performed by the Kaplan-Meier product limit method using the log-rank test of significance. Results Thirty cats were included in the study. Eleven had a cutaneous non-auricular melanoma, six had a tumour located on the pinna and 13 had a tumour in the oral cavity. Cats with auricular melanomas were significantly younger than cats with tumours in other locations. Location and presence of clinical signs were not of prognostic significance, but the achromic phenotype was significantly associated with a poorer prognosis. Twenty cats were treated with surgery and survived significantly longer than cats that received only medical treatment or that did not receive any treatment. According to our data, mitotic index, cytonuclear atypias, junctional activity, Melan A or S100 expression, and surgical margins were not associated with survival. Conclusions and relevance We show for the first time, in a large series, that the auricular form of melanoma affected significantly younger cats than other extraocular forms. Most feline non-ocular melanomas are malignant and achromic tumours are associated with a poorer prognosis. According to this study, surgery should be considered as a priority.

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Section: Introductionmentioning

confidence: 99%

Non-ocular melanomas in cats: a retrospective study of 30 cases

Chamel

Abadie

Albaric

et al. 2016

Journal of Feline Medicine and Surgery

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“…Melanocytic tumors are relatively rare in cats. The primary sites affected most commonly are intraocular, periocular and dermal sites, 1–28 although other primary locations involving oral, nares, digit and orbital lesions have been described. 8,10,20,21,29–31 Malignant melanoma appears to have an aggressive local behavior and a high risk for dissemination in cats, regardless of the primary site of origin.…”

Section: Introductionmentioning

confidence: 99%

“…8,10,20,21,29–31 Malignant melanoma appears to have an aggressive local behavior and a high risk for dissemination in cats, regardless of the primary site of origin. 7,10,13,15,18,21,26,27,32 Surgery and radiation therapy have been the primary modalities used for treatment of malignant melanoma in this species. 17,21,29,29,33–38 Therapies to address the metastatic potential of these tumors in cats have not been reported to date.…”

Section: Introductionmentioning

confidence: 99%

Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma – a retrospective study

Sarbu

Kitchell

Bergman³

2016

Journal of Feline Medicine and Surgery

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Objectives A xenogeneic human tyrosinase DNA vaccine was developed for treatment of dogs with oral malignant melanoma (Oncept; Merial). No studies have evaluated the safety or efficacy of this vaccine in cats. The purpose of this study was to evaluate the safety of the canine melanoma vaccine in cats diagnosed with melanoma. Methods Medical records were reviewed from cats diagnosed with malignant melanoma and treated with the canine melanoma DNA vaccine (Oncept). Data regarding signalment, melanoma location, treatments received, vaccine adverse effects and cause of death were collected. Results A total of 114 melanoma vaccines were administered to 24 cats. Seven cats (11.4%) had clinical adverse effects from a total of 13 vaccines classified as grade 1 or 2 based on the Veterinary Cooperative Oncology Group's common terminology criteria for adverse events v1.1. These included pain on vaccine administration, brief muscle fasciculation, transient inappetence, depression, nausea and mild increase in pigmentation at the injection site. Nineteen cats were deceased at study close. The most common cause of death was melanoma (14 cats). Hematological and biochemical changes were observed in six cats, five of which had concurrent disease or treatments that likely caused or greatly contributed to the laboratory abnormalities found. Therefore, these adverse events were considered unlikely to be caused by the melanoma vaccine. One cat had transient grade 1 hypoalbuminemia, which was possibly caused by the vaccination but not thoroughly evaluated. Conclusions and relevance The canine melanoma DNA vaccine can be safely administered to cats, with minimal risk of adverse effects.

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“…Neoplastic melanocytic pleural effusions are extremely uncommon in veterinary medicine and are typically associated with metastatic malignant melanomas and a poor prognosis 3,15,16 …”

Section: Discussionmentioning

confidence: 99%

Neoplastic melanocytic pleural effusion in a Portuguese water dog

Corda

Saavedra

Berghoff

et al. 2020

Veterinary Clinical Pathol

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A 9‐year‐old castrated male Portuguese water dog was presented following incomplete excision of a malignant melanoma at the left lip commissure by the referring veterinarian. Physical examination was otherwise unremarkable. The patient was staged using thoracic radiographs, abdominal ultrasound, and fine‐needle aspirates of the mandibular lymph nodes and spleen. Given the absence of any definitive evidence of metastasis, the malignant melanoma was surgically completely removed. The dog then received four melanoma vaccine doses as an adjuvant therapy and remained clinically healthy for more than 3 months after the last immunization. However, 232 days after the initial discovery of the lip mass, the dog was euthanized due to deterioration and a poor prognosis based on the presence of lung metastases and neoplastic melanocytic pleural effusion. The latter has been rarely reported in dogs, despite the high prevalence of oral malignant melanomas and the tendency of these tumors to metastasize to the lungs.

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Malignant Melanoma in Pleural Effusion in a 14-Year-Old Cat

Cited by 9 publications

References 13 publications

Non-ocular melanomas in cats: a retrospective study of 30 cases

Non-ocular melanomas in cats: a retrospective study of 30 cases

Safety of administering the canine melanoma DNA vaccine (Oncept) to cats with malignant melanoma – a retrospective study

Neoplastic melanocytic pleural effusion in a Portuguese water dog

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