Malignant Mediastinal Chemodectoma

Srougi, Victor; Anand, KuljeetSingh; Bharathy, Sarasa; Rao, Subba; Reddy, K.

doi:10.1378/chest.68.4.583

Cited by 12 publications

(4 citation statements)

References 6 publications

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“…If lesion cannot be removed completely then radiotherapy is an option although radioresistance has been seen. [12,26,27] Recurrence with incomplete removal, and even metastasis outside spinal canal, has been reported. [12,13,[20][21][22]28,29] Local recurrence rate of 12% has been seen.…”

Section: Discussionmentioning

confidence: 99%

Spinal paraganglioma: A case report

Telang¹,

Sinha²

2014

Int J Med Sci Public Health

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Paraganglioma is a neuroectodermal tumour which originates from the chromaffin cells. Paraganglioma of spinal cord is uncommon lesion and usually presents as intradural tumour within cauda equina. We present a case of 42 year old female having spinal paraganglioma which developed in lumbar segment of spinal cord. The patient complained the pain in lower back and both legs with sensory deficit in left lower limb. Preoperative MRI showed a intradural mass. Patient operated with laminectomy and durotomy with complete excision of mass. Histopathology and Immunohistochemistry study showed the Zellaballen pattern and positive markers for Viamentin, Synaptophysin, Chromogranin A and Neurone specific enolase. Paraganglioma is a rare tumor with recurrence potential so total precision excision is the best option to achieve cure and to reduce the chance of recurrence.

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Section: Discussionmentioning

confidence: 99%

Spinal paraganglioma: A case report

Telang¹,

Sinha²

2014

Int J Med Sci Public Health

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“…However multicentric 1,8 and malignant metastatic lesions 9 have also been reported with both synchronous and metachronous metastasis presenting at varying time intervals. 1,10,11 Reports of familial occurrence 12 and association with other tumours such as leiomyosarcomas, chordomas (the "Carney triad") 13 or pituitary adenomas 8 suggest a genetic basis for the tumour. A wide range of age at presentation of between 13 14 -74 15 years with a mean age of 46 years 15 has been reported with a slight male predominance (2:1).…”

Section: Discussionmentioning

confidence: 99%

“…In case of incomplete removal radiotherapy is an option although radioresistance has been reported. 10 Of late, I-131 labeled metaiodobenzylguanidine (MIBG) has been successfully used in managing these patients. 19 Although the median time for local recurrence has been estimated as 6 years 20 recurrences as late as 20 years have been reported.…”

Section: Discussionmentioning

confidence: 99%

Paraganglioma of the filum terminale

Sousa¹,

O’Brien²,

Crooks

2005

Journal of Clinical Neuroscience

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“…The decision to operate or irradiate should be based on a formula that considers tumor size and location, patient age and health, symptoms or signs, potential morbidity and the expertise and availability of those involved in treatment. Chemotherapy has no defined role for treatment at any stage 17 , 18 ) .…”

Section: Discussionmentioning

confidence: 99%

A Case of Cushing`s Syndrome in ACTH - secreting Mediastinal Paraganglioma

Park

et al. 2000

Korean J Intern Med

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Paragangliomas are unusual neuroendocrine cell tumors arising from paraganglia, of which ACTH-secreting cases in the mediastinum are exremely rare. A 51-year-old woman was admitted for generalized edema and weakness which began 5 months ago. Chest X-ray and CT scan revealed a tumor mass in the anterior mediastinum. The plasma cortisol and ACTH levels were very high. Other sources secreting ACTH, except mediastinal mass, were not found. Surgical excision of mediastinal mass and left supraclavicular lymph node was performed. The postoperative microscopic finding and immunohistochemical staining revealed organoid tumor cell nests (zellballen) and S-100 protein positive sustentacular cells which are characteristics of paraganglioma. This was thus a case of Cushing’s syndrome resulting from ectopic ACTH production in anterior mediastinal paraganglioma.

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Malignant Mediastinal Chemodectoma

Cited by 12 publications

References 6 publications

Spinal paraganglioma: A case report

Spinal paraganglioma: A case report

Paraganglioma of the filum terminale

A Case of Cushing`s Syndrome in ACTH - secreting Mediastinal Paraganglioma

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