Malignant lymphoma of mucosa‐associated lymphoid tissue

Isaacson, Peter G.; Spencer, Jo

doi:10.1111/j.1365-2559.1987.tb02654.x

Cited by 745 publications

(303 citation statements)

References 30 publications

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“…The distinct clinico-pathological entity of low-grade Bcell lymphomas arising from mucosa-associated lymphoid tissue (MALT) was first described in 1983 in a patient with primary gastrointestinal lymphoma [9]. Since then further reports have been published of similar tumours, of both low and intermediate grade, which have arisen from other organs including the lungs, salivary glands, thyroid gland, thymus, and less commonly, the orbit, bladder and genitourinary tract [10][11][12].…”

Section: Discussionmentioning

confidence: 99%

Radiological appearances of lymphomas arising from mucosa-associated lymphoid tissue (MALT) in the lung

et al. 1998

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We review the radiological findings in 13 patients with histologically proven (n = 10) or clinically diagnosed (n = 3) lymphomas arising in mucosa-associated lymphoid tissue (MALT) of the lung. These rare B-cell lymphomas typically follow an indolent course, and many cases are still being incorrectly described in current radiological literature under the term pseudolymphoma. The patients frequently give a history of autoimmune disease involving the affected organ, and involvement of another mucosal site as part of a disseminated MALT lymphoma, is common. The radiographic patterns of pulmonary parenchymal involvement in lung MALT lymphomas have been reviewed, and correlation made with their clinical behaviour.

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Section: Discussionmentioning

confidence: 99%

Radiological appearances of lymphomas arising from mucosa-associated lymphoid tissue (MALT) in the lung

et al. 1998

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“…Thirteen of these were classified as low-grade MALT lymphoma, 29 as high-grade MALT lymphoma (four of which contained separate fields of low-and high-grade tumour cells in the same tissue block) and five were classified as diffuse large B cell lymphoma without the presence of features of a low-grade MALT component (DLBCL). Classification was based on cri-teria described by Isaacson et al; 1,12,13 MALT origin was defined by the presence of a small cell component showing the typical features of MALT: reactive follicles surrounded by centrocyte-like cells, plasma cell differentiation and lymphoepithelial lesions. High-grade MALT lymphomas were characterised by the additional presence of sheets of large, blastic cells.…”

Section: Tissue Specimensmentioning

confidence: 99%

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1999

Leukemia

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Gastric MALT lymphoma is a distinct entity related to Helicobacter pylori gastritis. Some studies suggest a role for trisomy 3 in the genesis of these lymphomas, but they mainly focused on low-grade MALT lymphoma. Gastric MALT lymphoma, however, comprises a spectrum from low-to high-grade cases. Furthermore, its exact relation to primary diffuse large B cell lymphoma (DLBCL) of the stomach is not clear. We applied in situ hybridisation (ISH) with centromeric probes on 43 samples of 39 patients with primary gastric lymphoma (13 samples with low-grade MALT lymphoma, 25 with high-grade MALT lymphoma and five with DLBCL) to detect numerical aberrations of 10 chromosomes. ISH was performed immunohistochemically on nuclei isolated from paraffin-embedded resection tissue and on whole paraffin sections using immunofluorescence. In six of 13 low-grade MALT lymphomas trisomy was detected (46%) and mostly involved chromosome 3 (33%). In high-grade MALT lymphomas, trisomies were found in 16 of 25 cases (64%), mainly involving chromosomes 12 and 18. Trisomy 3 was present in only 13% of these cases. Of five DLBCL, only one showed trisomy. Nine of the 16 aberrant high-grade MALT lymphomas (56%) showed trisomy of more than one chromosome per case vs two of six for low-grade cases. In lymphomas with separate low-and high-grade tumour components some trisomies were detected in both components, whereas others occurred only in the high-grade tumour cells. This supports the hypothesis that high-grade MALT lymphomas can develop from a low-grade type and that this progression is accompanied by the acquisition of more genetic aberrations. However, trisomy 3 probably does not play a major role in this progression.

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“…In addition, most low-grade MALT lymphomas are at stage IE; a minority are at stage II,, according to Isaacson and Norton (1994). Only three (14%) of our stage II patients had low-grade MALT lymphoma.…”

Section: Discussionmentioning

confidence: 64%

A prospective study of surgery and adjuvant chemotherapy for primary gastric lymphoma stage II

Takenaka

Maruyama²,

Kinoshita³

et al. 1997

Br J Cancer

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Summary The standard management of primary gastric lymphoma (PGL) (stage 11) has not been established despite the use of various treatment modalities. The present prospective trial of combined surgery and chemotherapy for the treatment of PGL (stage 11) included 25 consecutive patients treated between July 1978 and December 1993. Twenty-one patients were treated with total gastrectomy and four with partial gastrectomy; this was followed by post-operative chemotherapy with m-VEPA (vincristine, cyclophosphamide, prednisolone and doxorubicin), followed by consolidation chemotherapy with VEMP (vindesine, cyclophosphamide, methotrexate and prednisolone) or VQEP (vindesine, carbazilquinone, cyclophosphamide and prednisolone). Twenty-one of the 25 patients who completed post-operative chemotherapy were free of relapse 26-203 (median 94) months after the gastrectomy. Of the four patients who did not complete the projected chemotherapy, two relapsed and died of lymphoma. Another patient with recurrent lymphoma died in an accident, and the fourth patient was in remission at 54 months after surgery. The post-operative overall and disease-free survival rates at 10 years for the 25 evaluable patients were 81.6% and 92.0% respectively. Major surgical complications and treatment-related death after chemotherapy were not observed. PGL (stage 11) appears to be curable when treated with gastrectomy and adjuvant chemotherapy.

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Malignant lymphoma of mucosa‐associated lymphoid tissue

Cited by 745 publications

References 30 publications

Radiological appearances of lymphomas arising from mucosa-associated lymphoid tissue (MALT) in the lung

Radiological appearances of lymphomas arising from mucosa-associated lymphoid tissue (MALT) in the lung

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A prospective study of surgery and adjuvant chemotherapy for primary gastric lymphoma stage II

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