Malignant Hyperthermia in Brazil: Analysis of Hotline Activity in 2009

Abstract

The number of calls per year in the Brazilian hotline service for MH is still low. The characteristics of MH episode were similar to those reported in other countries. The knowledge of MH in Brazil needs to be increased.

Idiopathic hyperCKemia and malignant hyperthermia susceptibility

“…This is further supported by the presence of dysmorphisms in some diseases associated with MH, such as the King-Denborough syndrome and Native American myopathy. 6,33 Study of muscular anatomopathology in the MHS patients resulted mostly in a final diagnosis of unspecified changes; whereas, in the case of patients nonsusceptible to MH, the resulting diagnosis was mitochondrial proliferation. Anatomopathological study does not allow for a diagnosis of MH susceptibility as up to 78% of the MHS patients can have normal features.…”

“…Malignant hyperthermia may also be expressed as a chronic myopathy, such as central core disease. 6 Susceptibility to MH is hereditary and autosomal dominant, and an in vitro muscular contracture test (IVCT) in response to exposure to halothane and caffeine is the gold standard for the diagnosis. 7 This study investigated susceptibility to MH in patients with hyperCKemia via the IVCT and a search of mutations in the RYR1 gene.…”

Malignant hyperthermia in a cleft lip and palate patient: A case report

“…The typical clinical features of this crisis are tachycardia, hypercarbia, tachypnea, hyperthermia, muscle rigidity, rhabdomyolysis and metabolic acidosis [1,8]. Rhabdomyolysis occurs with elevation in creatine kinase, and gives rise to hyperkalaemia which could lead to cardiac dysrhythmias or cardiac arrest and renal failure [9].…”