Malignant Hyperthermia and the Fluoride-Resistant Gene

Abstract

One hundred and six individuals from 33 families with a history of malignant hyperthermia have been investigated for plasma cholinesterase variants. An increased frequency of the fluoride-resistant gene has been found. Although an adequate explanation for our results is elusive, some hypotheses are discussed.

Cholinesterase Its significance in anaesthetic practice

“…Whereas Whittaker & Britten [57] found an increased frequency of fluoride-resistant genes in patients with a family history of malignant hyperthermia, Evans et al [58] found no such increase when they investigated the serum of patients who had actually shown susceptibility to the condition. In an editorial in the same issue of the journal in which both studies were published, Hall [59] seems to doubt that there is any connection between these two conditions.…”