Malignant Hypertensive Retinopathy Studied With Optical Coherence Tomography

Suzuki, Mina; Minamoto, Atsushi; Yamane, Kunio; Uka, Junko; Aoki, Seishiro; Mishima, Hiromu K.

doi:10.1097/00006982-200504000-00026

Cited by 12 publications

(10 citation statements)

References 2 publications

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“…Therefore, a possible explanation of our finding of thinner photoreceptor related retinal layers with increasing blood pressure could be through higher systolic blood pressure leading to intermittent reduction in blood flow at the DCP, leading to subtle changes in photoreceptor layer thickness on OCT imaging. An alternative explanation is that severe hypertension leads to choroidal permeability changes, which increases choroidal interstitial fluid and extends into the subretinal space causing subretinal fluid accumulation, and subsequent photoreceptor defects 43,44 .…”

Section: Discussionmentioning

confidence: 99%

Associations with photoreceptor thickness measures in the UK Biobank

Chua

Dhillon

Aslam

et al. 2019

Sci Rep

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Spectral-domain OCT (SD-OCT) provides high resolution images enabling identification of individual retinal layers. We included 32,923 participants aged 40–69 years old from UK Biobank. Questionnaires, physical examination, and eye examination including SD-OCT imaging were performed. SD OCT measured photoreceptor layer thickness includes photoreceptor layer thickness: inner nuclear layer-retinal pigment epithelium (INL-RPE) and the specific sublayers of the photoreceptor: inner nuclear layer-external limiting membrane (INL-ELM); external limiting membrane-inner segment outer segment (ELM-ISOS); and inner segment outer segment-retinal pigment epithelium (ISOS-RPE). In multivariate regression models, the total average INL-RPE was observed to be thinner in older aged, females, Black ethnicity, smokers, participants with higher systolic blood pressure, more negative refractive error, lower IOPcc and lower corneal hysteresis. The overall INL-ELM, ELM-ISOS and ISOS-RPE thickness was significantly associated with sex and race. Total average of INL-ELM thickness was additionally associated with age and refractive error, while ELM-ISOS was additionally associated with age, smoking status, SBP and refractive error; and ISOS-RPE was additionally associated with smoking status, IOPcc and corneal hysteresis. Hence, we found novel associations of ethnicity, smoking, systolic blood pressure, refraction, IOPcc and corneal hysteresis with photoreceptor thickness.

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Section: Discussionmentioning

confidence: 99%

Associations with photoreceptor thickness measures in the UK Biobank

Chua

Dhillon

Aslam

et al. 2019

Sci Rep

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“…Morphologic abnormalities associated with severe hypertension, as identified with TD-OCT, include SRF and macular edema. 13 However, choroidal abnormalities have not been investigated with conventional OCT due to poor light penetration past the retinal pigment epithelium (RPE). Relatively new enhanced depth imaging (EDI) techniques allow the choroid to be visualized on a microscopic level, so this is now technologically feasible.…”

Section: Introductionmentioning

confidence: 99%

Retinal and Choroidal Changes With Severe Hypertension and Their Association With Visual Outcome

Ahn

Woo

Park

2014

Investigative Ophthalmology & Visual Science

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“…[3][4][5][6] Especially in malignant hypertensive retinopathy, which occurs in the setting of severely elevated blood pressure, optic disc swelling and macular edema occur, which can cause an abrupt decline in vision. [7][8][9] The treatment of hypertensive retinopathy includes urgent antihypertensive management; however, no randomized controlled studies have evaluated whether treating the hypertension will reverse established hypertensive retinopathy changes. 2,8 Bevacizumab (Avastin Ò ), an antibody against vascular endothelial growth factor (anti-VEGF), has been injected intravitreally in several retinal diseases that have increased vascular permeability and edema.…”

Section: Introductionmentioning

confidence: 99%