Malignant Histiocytosis in a Domestic Cat: Cytomorphologic and Immunohistochemical Features

Walton, Raquel M.; Brown, Diane E.; Burkhard, Mary Jo; Donnelly, Kevin B.; Frank, Arthur J.; Obert, Leslie; Withrow, Stephen J.; Thrall, Mary Anna

doi:10.1111/j.1939-165x.1997.tb00708.x

Cited by 33 publications

(51 citation statements)

References 15 publications

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“…Lysozyme is considered a useful marker for mononuclear phagocytes, and had been used to confirm histiocytic differentiation in an immunohistochemical study of feline malignant histiocytosis [23]. However, in the study, the staining pattern of feline liver Kupffer cells was not mentioned.…”

Section: Discussionmentioning

confidence: 66%

Histopathological Characteristics of Ito Cells and Kupffer Cells in the Feline Liver

Uetsuka

Nishikawa

Yasoshima

et al. 2006

The Journal of Veterinary Medical Science

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ABSTRACT. The histopathological characteristics of Ito cells and Kupffer cells were investigated in the liver of 21 cats (age range: 6 months -18 years) autopsied in our laboratory during 2003. Immunohistochemical examinations were performed using antibodies against lysozyme, desmin and α-smooth muscle actin. No Kupffer cells reacted with the antibody against lysozyme. However, macrophages in the lung and spleen showed a positive reaction with the antibody. This finding suggests a possibility that the amount of lysozyme in the Kupffer cells of feline liver is comparatively small. On the other hand, large vacuole-laden cells were observed in the hepatic perisinusoid of some feline cases, and these cells showed a positive reaction with antibodies against desmin and α-smooth muscle actin. These cells could be Ito cells with large lipid vacuoles. This conclusion was supported by electron microscopic observation and oil red O staining. However, no such large vacuole-laden perisinusoidal cells were detected in the liver of young cats less than 2 years old. The present study revealed the histopathological features of Kupffer cells and Ito cells in the feline liver.

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Section: Discussionmentioning

confidence: 66%

Histopathological Characteristics of Ito Cells and Kupffer Cells in the Feline Liver

Uetsuka

Nishikawa

Yasoshima

et al. 2006

The Journal of Veterinary Medical Science

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“…10,14,18,37 The cats had a low packed cell volume (19-20%), normochromic or hypochromic, regenerative or nonregenerative anemia, hypoproteinemia, hyperbilirubinemia, thrombocytopenia, and prolonged thromboplastin time. 10,14,18,37 Hepatosplenomegaly with ascites and mediastinal and pulmonary masses with hydrothorax were observed. Histologic evaluations of the tumor masses revealed a proliferation of pleomorphic histiocytes, which usually displayed marked hemophagocytosis.…”

Section: Discussionmentioning

confidence: 99%

“…Histologic evaluations of the tumor masses revealed a proliferation of pleomorphic histiocytes, which usually displayed marked hemophagocytosis. The diagnosis of malignant histiocytosis was based on the morphology of the tumor cells, the hemophagocytic activity, and the variably positive immunohistochemical stains for lysozyme and Mac387 14,18,37 or positive reactions with a-1 antitrypsin, acid phosphatase, or nonspecific esterase. 10,18 These findings are most consistent with disseminated hemophagocytic histiocytic sarcomas of macrophage origin rather than histiocytic sarcomas of DC origin.…”

Section: Discussionmentioning

confidence: 99%

Feline Progressive Histiocytosis

2006

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Abstract. Histiocytic proliferative diseases include reactive and neoplastic proliferations of dendritic cells (DC) or macrophages. Various forms of DC proliferations have been documented in humans and dogs; their etiology is largely unknown. With the exception of a few case reports, histiocytic proliferations have not been characterized in cats. This study summarizes clinical, morphologic, and immunophenotypic features of a feline progressive histiocytosis (FPH) in 30 cats. There was no breed or age predilection. Females were more often affected than males. Solitary or multiple nonpruritic firm papules, nodules, and plaques had a predilection for feet, legs, and face. Lesions consisted of poorly circumscribed epitheliotropic (13/30) and nonepitheliotropic (17/30) histiocytic infiltrates of the superficial and deep dermis, with variable extension into the subcutis. The histiocytic population was relatively monomorphous early in the clinical course. With disease progression, cellular pleomorphism was more frequently encountered. Histiocytes expressed CD1a, CD1c, CD18, and major histocompatibility complex class II molecules. This immunophenotype suggests a DC origin of these lesions. Coexpression of E-cadherin, a feature of cutaneous Langerhans cells, was only observed in 3 cats. FPH followed a progressive clinical course; the lesions, however, were limited to the skin for an extended period of time. Terminal involvement of internal organs was documented in 7 cases. Treatment with chemotherapeutics or immunosuppressive and immunomodulatory drugs was not successful. The etiology of FPH remains unknown. FPH is best considered an initially indolent cutaneous neoplasm, which is mostly slowly progressive and may spread beyond the skin in the terminal stage.

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“…3,19,21 To facilitate labeling with CD3, tissues were pretreated by incubation in 0.1% porcine trypsin. Antigen recovery was accomplished for MAC387, glial fibrillary acid protein (GFAP), and vimentin by exposure to microwaves.…”

Section: Immunohistochemical Stainingmentioning

confidence: 99%

Feline Hodgkin's-like Lymphoma: 20 Cases (1992–1999)

Walton

Hendrick

2001

Vet Pathol

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Abstract. We identified 20 cases of feline lymphadenopathy that conform to many clinical and histologic manifestations of human Hodgkin's disease. Histologic subtypes encountered included lymphocyte predominance (nine cases), mixed cellularity (nine cases), and nodular sclerosis (two cases). Two cases were not easily classified; fibrous bands were present, but the absence of nodules supported a subclassification of mixed cellularity Hodgkin's disease. Immunohistochemical staining of the tissues using antibodies against the pan T-cell antigen CD3, the human B-lymphocyte antigen 36 (BLA.36), the pan B-lymphocyte and plasma cell marker CD79a, and a myeloid antigen (MAC387) confirmed the phenotypic heterogeneity of the tumor. Classic ReedSternberg (RS) cells and mononuclear, multinucleate, and lacunar cell variants did not stain with any of the antibodies used. In contrast, lymphohistiocytic RS variants (LϩH cells) reacted positively to BLA.36 and CD79a B-cell markers. Eighteen of 20 affected cats were Ն6 years of age (range, 1-14 years). A sex predilection could not be identified. These findings support the existence of Hodgkin's-like lymphoma in the cat. Proper identification of this disease in the cat will enable further characterization of clinical features and biologic behavior to determine whether there are significant differences in the treatment and prognosis of feline Hodgkin's-like lymphoma compared with non-Hodgkin's lymphoma.

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Malignant Histiocytosis in a Domestic Cat: Cytomorphologic and Immunohistochemical Features

Cited by 33 publications

References 15 publications

Histopathological Characteristics of Ito Cells and Kupffer Cells in the Feline Liver

Histopathological Characteristics of Ito Cells and Kupffer Cells in the Feline Liver

Feline Progressive Histiocytosis

Feline Hodgkin's-like Lymphoma: 20 Cases (1992–1999)

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