Malignant Hidradenocarcinoma in the Lower Extremity: A Case Report of a Rare Tumor

Kane, Brendan; Adler, Evan; Bhandari, Tarun; Rose, Michael; DiGuglielmo, Nicola; Sun, Xin

doi:10.1053/j.jfas.2017.10.024

Cited by 7 publications

(6 citation statements)

References 17 publications

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“…In past reports, lesions mostly occurred in the head and neck region. Our case is only the second malignant transformation of NH to be reported in the lower leg [ 8 ]. Contrary to its benign counterpart, MNH shows aggressive behavior with a high frequency of local recurrence and metastasis.…”

Section: Discussionmentioning

confidence: 98%

Malignant Transformation of Nodular Hidradenoma in the Lower Leg

et al. 2018

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Nodular hidradenoma (NH) is a benign adnexal tumor that arises from either eccrine or apocrine sweat glands. NH can originate from any cutaneous site, but the most common sites are the head and anterior surface of the trunk, with very rare cases in the extremities. Long-standing NH has been reported to undergo malignant transformation to malignant NH (MNH); however, its occurrence in the lower leg is extremely rare with only one other case reported to date. In this report, we present a rare case of MNH occurring in the lower leg which was resected with the intent to make a diagnosis. At the final follow-up after 11 months, no local recurrence or metastasis has been observed.

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Section: Discussionmentioning

confidence: 98%

Malignant Transformation of Nodular Hidradenoma in the Lower Leg

et al. 2018

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“…It can recur locally or metastasize distantly. Only a few cases have been reported, and the differentiation from benign hidradenoma by only imaging is difficult ( 2 8 9 ).…”

Section: Discussionmentioning

confidence: 99%

Sonographic and Strain Elastographic Findings of a Clear Cell Hidradenoma that Looked Like an Epidermoid Tumor: A Case Report

김

박

김

2022

J Korean Soc Radiol

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Clear cell hidradenoma (CCH) is a rare tumor of the sweat glands of eccrine or apocrine differentiation. It can occur anywhere in the body, but common sites of involvement are the head, face, trunk, and extremities. Although several reports have described sonographic findings of CCH, only one study on the axilla mentioned its strain elastographic findings. Here, we present a case of CCH in the right calf with its sonographic and strain elastographic findings in a tumor that looked like an epidermoid tumor.

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“…However, approximately 66% of patients present distant extension of the tumor (39% to lymph nodes and 28% to other distant organs that include bone, lung, pleura, skin, and among others), and the local recurrence rate of this type of tumor is high (up to 50%). Therefore, surgical treatment of the tumor is currently combined with regional lymphadenectomy whenever possible if there is regional lymph node involvement, and even prophylactically [ 2 , 3 , 4 , 8 , 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Sentinel node biopsy can be useful in the early diagnosis of lymph node metastases in the subclinical phase in those cases with lesions with data suggesting a high risk of malignancy, such as invasion more than 2 mm in depth, perineural invasion, and histological dedifferentiation [ 2 , 8 , 9 ].…”

Section: Discussionmentioning

confidence: 99%

Hidradenocarcinoma over a Surgically Excised Hidradenoma of the Foot. A Case Report of a Very Rare Presentation of a Rare Tumor

Saz¹,

Medrano²,

Nielsen³

et al. 2022

JOCR

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Introduction: Hidradenocarcinomas are very rare and aggressive soft-tissue tumors, originated from sweat gland cells, which are located most frequently in head and neck, being their appearance at the extremities rare. This kind of tumor usually appears de novo and very few cases have been reported until now of appearance over benign lesions such as hidradenomas. Malignancy progression rate of hidradenomas is unknown, and this benign lesion has clinical and histopathological characteristics in common with hidradenocarcinomas that could lead to misdiagnosis. Hidradenocarcinomas have a very poor survival rate; therefore, an early diagnosis is essential for a better prognosis, and that is the reason why hidradenomas should be widely excised from the beginning, instead of performing marginal resections of this lesions that could lead to an aggressive recurrence. Case Presentation: Here is a case report of a 27-year-old woman diagnosed with a hidradenocarcinoma over a previously excised hidradenoma in the right foot. The diagnosis was made after right pelvic and inguinal lymphadenopathies appeared few months after a new small asymptomatic lump appeared at the same place in the sole of the right foot were the excised hidradenoma five years before was located. Lymph node biopsy was performed, with histopathological diagnosis of hidradenocarcinoma metastasis. Surgical local wide excision of the lump at the foot and lymphadenectomies was performed. Histopathological analysis of the samples confirmed the diagnosis of hidradenocarcinoma. The patient later received adjuvant radiotherapy and after one year there are no signs of disease recurrence. Conclusion: Many questions remain uncertain about the management and treatment of hidradenocarcinomas due to the rarity of this type of tumor. Although targeted molecular therapies have shown promising results, more studies in this field are necessary. An early diagnosis and differentiation from its benign counterparts that allow local control of the disease before spreading is essential to improve survival rates.

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Malignant Hidradenocarcinoma in the Lower Extremity: A Case Report of a Rare Tumor

Cited by 7 publications

References 17 publications

Malignant Transformation of Nodular Hidradenoma in the Lower Leg

Malignant Transformation of Nodular Hidradenoma in the Lower Leg

Sonographic and Strain Elastographic Findings of a Clear Cell Hidradenoma that Looked Like an Epidermoid Tumor: A Case Report

Hidradenocarcinoma over a Surgically Excised Hidradenoma of the Foot. A Case Report of a Very Rare Presentation of a Rare Tumor

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