Malignant Hemangioendothelioma

Ihda, Hazuki; Tokura, Y.; Fushimi, Misao; Yokote, Ryuichi; Hashizume, Hideo; Shirahama, Shigeho; Iwatsuki, Keiji; MURAKAMI, KYOKO; Takigawa, Masaharu

doi:10.1111/j.1365-4362.1995.tb04406.x

Cited by 15 publications

(5 citation statements)

References 24 publications

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“…Systemic administration of high dose recombinant interleukin-2 (rIL-2) has been shown to inhibit pulmonary metastasis of angiosarcoma of the skin [17]. The mechanism of rIL-2 is thought to involve direct inhibition of tumor cells and activation of natural killer cells and lymphokine-activated killer cells [4,18]. Two chemotherapeutic combinations have demonstrated partial and full effects: doxorubicin/ifofsamide and docetaxel/gemcitabine.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Primary Pulmonary Angiosarcoma

Judy¹,

Predina²,

Mittal³

et al. 2011

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Angiosarcoma is an extremely aggressive tumor with a high rate of mortality. It can arise in any tissue of the body and is most commonly found in the skin and soft tissue[1]. Pulmonary angiosarcoma is usually secondary to a primary location of the body and presents as both solitary and multiple nodules. Primary pulmonary angiosarcoma is a rare disease with less than 20 cases reported in the English literature. In our report we present a case of metastatic primary pulmonary angiosarcoma involving the most ( > 100) pulmonary nodules known to date. Novel treatment strategy using an anti-angiogenic inhibitor was used to treat this disease for the first time to our knowledge; however, it was unsuccessful in controlling disease progression. This report reviews the literature of this rare and devastating disease

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Section: Discussionmentioning

confidence: 99%

Metastatic Primary Pulmonary Angiosarcoma

Judy¹,

Predina²,

Mittal³

et al. 2011

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“…Angiosarcoma of the scalp is an aggressive tumor characterized by a rapid and fatal process. Treatment for this tumor is composed of excision, radiation, polychemotherapy, and immunotherapy, in which rIL‐2 is often used 1,4 . The therapeutic mechanism of rIL‐2 in AS is thought to involve the direct effect and activation of NK cells and LAK cells, although the activity of these immune cells is often of a low level in elderly patients 1 .…”

Section: Discussionmentioning

confidence: 99%

“…Local injections of recombinant interleukin‐2 (rIL‐2) is known to improve the prognosis of angiosarcoma of the scalp (AS) 1 . In addition, it is thought to have a direct effect on tumor cells, and can activate natural killer (NK) cells and lymphokine activated killer (LAK) cells.…”

Section: Case Reportmentioning

confidence: 99%

Angiosarcoma of the scalp treated with OK‐432 and rIL‐2

et al. 2002

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“…Recombinant interleukin-2 brings out lymphokineactivated killer (LAK) cells and natural killer (NK) cells, and makes these cytotoxic cells increase ICAM-1 expression to stick easily to neoplastic cells. There are many reports (5,7) in which interleukin-2 has been effective for angiosarcoma, usually partially.…”

Section: Discussionmentioning

confidence: 99%