Malignant Granular Cell Tumor of the Skull Base

Meling, Torstein R.; Fridrich, K.; Evensen, J. F.; Nedregaard, Bård

doi:10.1055/s-2007-992763

Cited by 14 publications

(2 citation statements)

References 33 publications

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“…Additionally, the knowledge about the variations of the vertebrobasilar arterial complex is important for surgeons operating at the skull base, craniocervical junction, cervical region and for clinicians interpreting the imaging of this region (SHOJA, TUBBS, KHAKI et al, 2006). Moreover, numerous studies (MIZUTANI, ARUGA, KIRINO et al, 1995;MOKRI, HOUSER, SANDOK et al, 1988;SMITH, SNYDERMAN, KASSAM et al, 2002;MELING, FRIDRICH, EVENSEN et al, 2008;KOCAELI, CHAALALA, ANDALUZ et al, 2009;MATSUSHIMA, KAWASHIMA, MASUOKA et al, 2010;GUPTA, RADHAKRISHNAN, PALIMAR et al, 2013), involving structures of the skull base have described important morphological, functional and clinical data about the VA, including those related to VA hypoplasia (BLICKENSTAFF, WEAVER, YELLIN et al, 1989). Thus, in this study we report an additional rare case of VA hypoplasia emphasizing some aspects of this clinical and morphological vascular unusual configuration.…”

Section: Introductionsupporting

confidence: 53%

Hypoplasia of the vertebral artery in human - a case report

Campos

2015

J Morphol Sci

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Hypoplasia of the vertebral artery (VA) is rare, and incidentally encountered in radiological imaging techniques. During routine activities in the Laboratory of Human Anatomy from University of Santa Cruz do Sul, Brazil, it was observed a 70 years old male cadaver with hypoplasia of the right VA. Thus, the purpose of this study is to report this case of hypoplasia of the VA emphasizing some morphological, functional and clinical data about this rare vascular abnormality, in order to offer useful information to anatomists, radiologists, vascular and head and neck surgeons. Moreover, to our knowledge, this variation has not been cited in recent medical literature.

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Section: Introductionsupporting

confidence: 53%

Hypoplasia of the vertebral artery in human - a case report

Campos

2015

J Morphol Sci

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“…[2,3] The gold standard of treatment is surgical resection, as the tumor is resistant to chemotherapy and radiation therapy. [4,5] To the best of our knowledge, 17 cases of malignant granular cell tumors arising from various peripheral nerves have been reported so far. [4,[6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21] We report a case of a malignant granular cell tumor originating from the ulnar nerve with a good clinical outcome.…”

Section: Introductionmentioning

confidence: 99%

Malignant granular cell tumor of the ulnar nerve: A case report of long-term follow-up and literature review

Morinaga¹,

Yamamoto²,

Hayashi³

et al. 2021

CRCP

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Background: The incidence of malignant granular cell tumor, an extremely rare Schwann cell-derived tumor with a poor prognosis, is reported to be approximately 0.2% of malignant soft tissue tumors. We report a case of a malignant granular cell tumor originating from the ulnar nerve.Case presentation: A 71-year-old woman presented with a mass in her right forearm. Magnetic resonance imaging showed a tumor with homogenous intensity of T1 and heterogeneous hyperintensity of T2, continuous with the ulnar nerve. Incisional biopsy revealed a malignant granular cell tumor, and marginal excision of the tumor was performed. Histologically, the tumor size was 9.2 cm and consisted of eosinophilic, granular polygonal to round and spindle-shaped cells, with vesicular and prominent nucleoli, and increased mitosis. Immunohistochemically, the tumor cells were positive for S-100 protein, CD68, H3K27me3, TFE3, and SOX10 and negative for smooth muscle alpha-actin, desmin, cytokeratin AE1/3, epithelial membrane antigen, and synaptophysin. The Ki-67 positivity rate was 12%. These findings were consistent with those of malignant granular cell tumors. In addition, no metastasis or recurrence was observed 15 years after the excision.Conclusion: Surgical resection is the standard treatment option. In our case, the diagnostic criteria for malignant granular cell tumors were histologically met. Patients with malignant granular cell tumors have a poor prognosis. However, no metastasis or recurrence was observed in this case 15 years after the surgery.

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