Malignant granular cell tumor: A look into the diagnostic criteria

Nasser, Haitham; Ahmed, Yasin; Szpunar, Susan; Kowalski, Paul

doi:10.1016/j.prp.2010.12.007

Cited by 92 publications

(92 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…They also evaluated the immunohistologic criteria and reported that the expression of p53 and Ki-67 was significantly higher in malignant tumors. Recently, Nasser et al [21], aiming to simplify these criteria, classified these tumors based on the presence of only necrosis and/or mitoses, but stressed the need to communicate abnormal findings in the pathology report. They reserve the malignant designation for tumors that present with metastatic disease.…”

Section: Discussionmentioning

confidence: 99%

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

Kardhashi

Deliso

Renna

et al. 2012

Gynecol Obstet Invest

View full text Add to dashboard Cite

Granular cell tumors (GCTs) are uncommon soft tissue tumors of neural derivation, as supported by immunohistochemical and ultrastructural evidence. Vulvar involvement has been reported in 7–16%. This paper presents the cases of a 60-year-old woman and her 32-year-old niece with a strong family history of cancer, both presenting with an enlarging mass on their left labia majora. The lesions were treated by simple surgical excision. Histopathological examination revealed a benign vulvar GCT in both lesions. This is the first reported case of GCT of the vulva in the same family. The possible familial component of GCT needs further investigation. A systematic review of the literature on vulvar GCTs is carried out, the most complete one to date. This review unexpectedly reveals that there have been more than 130 cases of GCT of the vulva reported to date, only 7 of which were malignant. Since 5–25% of patients have multiple lesions, before planning treatment, clinicians should exclude multicentric lesions. After surgical treatment, if there is any evidence of tumor in the surgical margin, wider local excision should be performed. Regular follow-up is important for diagnosing a possible recurrence or a new lesion.

show abstract

Section: Discussionmentioning

confidence: 99%

Benign Granular Cell Tumor of the Vulva: First Report of Multiple Cases in a Family

Kardhashi

Deliso

Renna

et al. 2012

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…Toutefois, Fanburg-Smith et al ont proposé d'associer 6 critères pour évaluer la malignité de ces tumeurs : nécrose « en carte de géographie », aspect « sarcomatoïde » des cellules, noyaux vésiculaires avec nucléole proéminent, mitoses > 2/10 HPF, augmentation du rapport nucléo-cytoplasmique, polymorphisme marqué. D'autres auteurs rapportent que la plupart des tumeurs à cellules géantes malignes présentent un index mitotique élevé et de la nécrose [69] ; mais ces paramètres ne permettent pas d'identifier toutes les tumeurs à cellules géantes malignes qui métastasent [70].…”

Section: Tumeurs à Cellules Granuleuses Malignesunclassified

Les tumeurs des gaines des nerfs périphériques

Guellec

2015

Annales de Pathologie

View full text Add to dashboard Cite

“…Puede aparecer en cualquier región anatómica excepto las vísceras, aunque tiene predilección por las extremidades y el tronco [9][10][11][12][13][14] . La FN debe incluirse en el diagnóstico diferencial, especialmente en pacientes con una lesión en partes blandas de rápido crecimiento o con una historia reciente de traumatismo.…”

Section: Fascitis Nodularunclassified

“…La FN se caracteriza histológicamente por una proliferación de fibroblastos y miofibroblastos asociados generalmente a un estroma mixoide. Las células no exhiben atipia citológica ni mitosis atípicas [9][10][11][12][13][14] .…”

Section: Fascitis Nodularunclassified

“…La cantidad de tumores benignos que pueden aparecer en la pared abdominal es muy amplia, e incluye todas aquellas neoplasias benignas originadas en cualquier estructura histológica de la piel, la grasa y los músculos de la pared abdominal [10][11][12][13][14] de músculo liso (leiomiomas), tejido nervioso (schwanomas, neurofibromas), quistes de inclusión epidérmica o sebáceos, fibromas, histiocitoma fibroso benigno y lesiones pigmentadas benignas (nevus) [10][11][12][13][14] . El aspecto macroscópico de la mayoría de estos tumores es de lesión benigna, con ciertos rasgos que definen algunos tipos histológicos específicos.…”

Section: Tumores Benignosunclassified

See 1 more Smart Citation