Malignant gliomas: early diagnosis and clinical aspects

Silvani, Antonio; Gaviani, Paola; Lamperti, E.; Botturi, A.; Ferrari, Daniela; Simonetti, G.; Salmaggi, Andrea

doi:10.1007/s10072-011-0788-9

Cited by 13 publications

(9 citation statements)

References 5 publications

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“…The temporal lobes of the cerebral hemispheres are the most widely acknowledged location [11]. Although no single cause for gliomas has been identified, increased exposure to electric and magnetic fields, plastics, and rubber at work have been suggested as contributing factors [12].…”

Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Predicting the Grade of Glioma Keeping Histopathology as the Gold Standard

Rafique¹,

Awan²,

Iqbal³

et al. 2022

Cureus

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BackgroundGliomas are the most prevalent intrinsic tumors of the central nervous system and are categorized from grade I to grade IV. Magnetic resonance imaging (MRI) provides exact diagnosis, prognosis, and assessment of tumor response to current chemotherapy/immunotherapy and radiation therapy. With histopathology serving as the gold standard, we aimed to assess the diagnostic accuracy of magnetic resonance spectroscopy (MRS) in predicting glioma grade.

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Section: Discussionmentioning

confidence: 99%

Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Predicting the Grade of Glioma Keeping Histopathology as the Gold Standard

Rafique¹,

Awan²,

Iqbal³

et al. 2022

Cureus

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“…Patients with PBT have diverse clinical manifestations and impairments due to variability in underlying neurobiology, locations, and treatment regimens. 32,44 For instance, tumors located near the neural substrates that regulate sleep-wake rhythms and hormonal secretions may disrupt the patient's sleep patterns or quality. However, such an effect of tumor laterality or location on sleep or the HRQoL outcomes was not found in PBT patients.…”

Section: Neuro-oncologymentioning

confidence: 99%

Sleep disturbance of adults with a brain tumor and their family caregivers: a systematic review

2017

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The high incidence and psychophysiological morbidities of sleep disturbance in cancer have been increasingly recognized. Yet, more detailed understanding of sleep disturbance and options for management have been neglected areas in both clinical care and research. Brain tumor patients have been particularly overlooked. A systematic search of the literature from 1990 to 2015 was performed to review sleep disturbance in adults with primary or secondary brain tumor and their family caregivers. Fifty eligible studies were identified, of which 12 focused on sleep, 37 reported sleep items within a health-related quality of life measure and 1 reported caregivers' sleep. No sleep intervention has been developed or tested for brain tumor patients. Sleep disturbance and somnolence were frequently reported as the most severely rated symptoms within health-related quality of life across the disease course or treatments, along with fatigue. However, sleep-focused studies yielded inconsistent results in small samples of mostly benign brain tumors in long-term remission from total tumor resection. The research using standardized, multifaceted sleep assessments, particularly in patients with malignant brain tumor and caregivers who are undergoing treatment, is seriously lacking. A more systematic examination of sleep disturbance is warranted to inform the development of better symptom management programs in this population.

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“…5 Common symptoms and side effects include seizure, nausea and vomiting, and headache. [6][7][8] To address the neurologic symptoms associated with glioma, patients are often prescribed glucocorticoids (levetiracetam followed by lacosamide or valproic acid are agents of choice); however, long-term steroid use may have adverse effects. 9 While standard management for grade III-IV tumorsmaximal safe resection followed by chemoradiation 10 -may be associated with temporary amelioration of symptoms, the majority of patients suffer declining functional and cognitive status as the tumor progresses.…”

Section: Introductionmentioning

confidence: 99%

Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida

Reblin

Sahebjam

Peeri

et al. 2019

Journal of Palliative Medicine

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Background: Glioma is a devastating primary tumor of the central nervous system with difficult-to-manage symptoms. Cannabis products have been postulated to potentially benefit glioma patients. Recent state legalization allowed investigators an opportunity to study glioma patients' adoption of medical marijuana (MM). Objective: Our goals were to: (1) determine the prevalence of marijuana use, both through physician recommendation and self-medication, and (2) evaluate its perceived risks and benefits in glioma patients. Design: Self-report data were collected and descriptive analyses were conducted. Setting/Subjects: Participants were adult, English-speaking patients undergoing treatment for primary nonrecurrent malignant glioma in neuro-oncology clinics at an NCI-designated Comprehensive Cancer Center. Measurements: The survey on MM was adapted from previous research and included questions on knowledge and attitudes toward MM; use, frequency, type, and sourcing of MM; and reasons for use of MM and perceived symptom relief among users. Results: A total of 73 patients were surveyed. The majority of participants were aware that MM was legal in the state, and most reported learning of this through the media. Over 70% of participants reported having considered using MM, and a third reported using marijuana products after their diagnosis. Most received recommendations from friends/family rather than a medical provider, and only half of the users had obtained a physician's recommendation. Users generally reported benefits. Conclusions: With the increasing national conversation that accompanies legalization, glioma patients are pursuing marijuana for the treatment for their symptoms. More research and education is needed to bring health care providers into the conversation.

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Malignant gliomas: early diagnosis and clinical aspects

Cited by 13 publications

References 5 publications

Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Predicting the Grade of Glioma Keeping Histopathology as the Gold Standard

Diagnostic Accuracy of Magnetic Resonance Spectroscopy in Predicting the Grade of Glioma Keeping Histopathology as the Gold Standard

Sleep disturbance of adults with a brain tumor and their family caregivers: a systematic review

Medical Cannabis Use in Glioma Patients Treated at a Comprehensive Cancer Center in Florida

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