Malignant giant cell tumor of soft parts.
            <i>An analysis of 32 cases</i>

Guccion, John G.; Enzinger, Franz M.

doi:10.1002/1097-0142(197206)29:6<1518::aid-cncr2820290616>3.0.co;2-#

Cited by 251 publications

(150 citation statements)

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“…Three (cats 1, 2, and 3) were giant cell variants of malignant fibrous histiocytoma as described by Guccion and Enzinger [5] who reviewed 32 such malignant extraskeletal giant cell tumors in man and concluded that they were malignant tumors of histiocytes.…”

Section: Discussionmentioning

confidence: 95%

“…Furthermore, the histiocytic cells may assume an epithelioid appearance or they may be multinucleated, as in the giant cell tumor of soft tissues, which may contain extremely large giant cells with numerous nuclei [5]. This cellular pleomorphism was responsible for the plethora of names given to this group of tumors, including epithelioid sarcoma, malignant histiocytoma, and reticulum cell sarcoma of soft parts [4, 111. These tumors are malignant, and there are metastases and local recurrences.…”

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confidence: 99%

“…If superficial, it is more likely to recur after excision; distant metastases are exceptional [5]. The tumor of the deeper tissues is more likely to metastasize to distant sites such as the lung and regional lymph nodes [5]. clinical staging and treatment as part of a referral program designed for studies in comparative oncology.…”

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confidence: 99%

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Malignant Fibrous Histiocytoma in Dogs and Cats

et al. 1979

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Abstract. Five soft tissue tumors of varied morphology in dogs and cats were classified as malignant fibrous histiocytomas on the basis of their histologic composition. All were composed of varying mixtures of histiocytes and fibroblasts and three contained large multinucleated cells. This giant cell variant of malignant fibrous histiocytoma was seen only in cats. These tumors are comparable to those described in man as malignant fibrous histiocytoma on the basis of the malignant histiocyte and its varied morphology and function.

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Section: Discussionmentioning

confidence: 95%

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confidence: 99%

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Malignant Fibrous Histiocytoma in Dogs and Cats

et al. 1979

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“…The five previously described subtypes of MFH seem to have few links, if any, to tumors of fibrohistiocytic differentiation, and the angiomatoid variant is no longer thought to be a fully sarcomatous member of STS (Costa and Weiss, 1990;Fanburg-Smith and Miettinen, 1999). Rather, the giant cell variant shares characteristics common to giant-cell-rich osteosarcoma of soft tissues (Guccion and Enzinger, 1972) and a number of inflammatory MFH overlap with inflammatory LMS (Merchant et al, 1995). Additionally, poorly differentiated myxoid MFH merge with pleomorphic MFH (Weiss and Enzinger, 1977), which are no longer thought to be tumors of true histiocytic differentiation.…”

Section: Derré Et Almentioning

confidence: 99%

Leiomyosarcomas and Most Malignant Fibrous Histiocytomas Share Very Similar Comparative Genomic Hybridization Imbalances: An Analysis of a Series of 27 Leiomyosarcomas

Derré

Lagacé²,

André

et al. 2001

Laboratory Investigation

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SUMMARY:Twenty-seven tumor samples with a diagnosis of leiomyosarcomas (LMS) were characterized by comparative genomic hybridization. The results were compared with immunohistochemical analysis of the smooth muscle profile of the tumors and expression of the RB1 gene protein. The comparative genomic hybridization profiles suggested that 7 of the 27 tumors might have been misclassified. High levels of DNA amplification were detected in 20 different small regions and recurrently involved bands 1p34, 1q21, 12q13-15, 17p, and 22q. Most recurrent simple gains were noted at sites such as 1p3, 1q21, 15q12-15, 16p, 17p and 17q, 19, 20q, 22q, and Xp. Significant losses of chromosome 13 were detected in 19 of the 27 tumors with a putative common region of loss in bands 13q14 -21. Losses of chromosomes 1q, 2p and 2q, 4q, 9p, 10p and 10q, 11p and 11q23, and 16q were also highly recurrent. A comparative analysis between the most frequent genomic imbalances observed in this study of LMS and the genomic imbalances observed in a large proportion of malignant fibrous histiocytomas (MFH) from a previous study demonstrated that both types of tumors had similar recurrent imbalances. Although MFH were once thought to be a separate member of the soft tissue sarcoma family, our observations support the hypothesis that MFH are a morphologic modulation in the tumoral progression of other sarcomas, particularly LMS. (Lab Invest 2001, 81:211-215).L eiomyosarcomas (LMS) are relatively frequent sarcomas of adult life. They are principally tumors of uterine or gastrointestinal origin, but also account for 5% to 10% of soft tissue sarcomas (STS) (Enzinger and Weiss, 1995). Within the past few years, with better identification of dedifferentiated liposarcomas and the recognition of malignant fibrous histiocytomas (MFH) as a separate entity, the relative incidence of LMS among STS has changed. The recent characterization of gastrointestinal stromal tumors (GIST) as a distinct classification also influences the incidence of gastrointestinal and retroperitoneal LMS. Contrary to MFH, osteosarcomas, or fibrosarcomas, LMS rarely occur after radiation, but may develop in patients with a constitutional inactivation of one allele of the RB1 gene and with a previous diagnosis of bilateral retinoblastoma. LMS are much more common in women than men, even for nonuterine locations. Until now, few cytogenetic or molecular data were available for LMS (Mandahl et al, 2000), and only a few series were analyzed by comparative genomic hybridization (CGH) (El-Rifai et al, 1998;Otano-Joos et al, 1998;Packenham et al, 1997;Parente et al, 1999). In this study, we analyzed a series of 27 LMS by immunohistochemistry and CGH. We found that the most frequent genomic alterations in LMS were losses in the 13q14 -21 region. LMS and a large proportion of MFH were also found to share very similar CGH imbalance profiles, which suggests that these two tumors may correspond to different differentiation states of a single tumor type. Results Imbalances Detected by CGHOne of the ...

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“…Soon after the first definition of the tumor by Salm and Sissons in 1972, Guccion and Enzinger have described the malignant type of the tumor in the analysis of another series composed of 32 cases [4]. Later Soule and Enriquez has reported the benign and malignant forms of histiocytic lesions in 65 cases including 5 tumors which were histologically similar to the tumors defined by Guccion and Enzinger [5].…”

Section: Discussionmentioning

confidence: 93%