Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: Ultrastructural and immunohistochemical study and review of the literature

Nielsen, Anne Bjerg; Kiaer, T

doi:10.1016/0046-8177(89)90070-1

Cited by 68 publications

(32 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The most consistent genetic rearrangement in both localized and diffuse types of PVNS is in chromosome 1p11-13, a site for CSF-1 gene, which most commonly fuses to COL6a3 on chromosome 2q35 (34,35). Trisomy of chromosomes 5 and 7 has also been reported in diffuse and malignant PVNS (8,36). These cytogenetic aberrations are seen in the majority but not all cases of PVNS.…”

Section: Pathologic Featuresmentioning

confidence: 88%

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Rhee²,

et al. 2008

View full text Add to dashboard Cite

Pigmented villonodular synovitis (PVNS) represents an uncommon benign neoplastic process that may involve the synovium of the joint diffusely or focally (PVNS) or that may occur extraarticularly in a bursa (pigmented villonodular bursitis [PVNB]) or tendon sheath (pigmented villonodular tenosynovitis [PVNTS]). Pathologic specimens of the hypertrophic synovium may appear villous, nodular, or villonodular, and hemosiderin deposition, often prominent, is seen in most cases. The knee, followed by the hip, is the most common location for PVNS or PVNB, whereas PVNTS occurs most often in the hand and foot. PVNTS is also referred to as giant cell tumor of the tendon sheath (GCTTS). PVNTS is the most common form of this disease by a ratio of approximately 3:1. Radiographs reveal nonspecific features of a joint effusion in PVNS, a focal soft-tissue mass in PVNB or PVNTS, or a normal appearance. Extrinsic erosion of bone (on both sides of the joint) may also be seen and is most frequent with intraarticular involvement of the hip (>90% of cases). Cross-sectional imaging reveals diffuse involvement of the synovium (PVNS), an intimate relationship to the tendon (PVTNS), or a typical bursal location (PVNB), findings that suggest the diagnosis. However, the magnetic resonance (MR) imaging findings of prominent low signal intensity (seen with T2-weighting) and "blooming" artifact from the hemosiderin (seen with gradient-echo sequences) are nearly pathognomonic of this diagnosis. In addition, MR imaging is optimal for evaluating lesion extent. This information is crucial to guide treatment and to achieve complete surgical resection. Recurrence is more common with diffuse intraarticular disease and is difficult to distinguish, both pathologically and radiologically, from the rare complication of malignant PVNS. Recognizing the appearances of the various types of PVNS, which reflect their pathologic characteristics, improves radiologic assessment and is important for optimal patient management.

show abstract

Section: Pathologic Featuresmentioning

confidence: 88%

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Rhee²,

et al. 2008

View full text Add to dashboard Cite

show abstract

“…9 However, their capacity for a certain degree of autonomous growth, local recurrence if inadequately excised and rarely metastasis speaks strongly for a neoplastic theory. 4,16,17 Although histomorphologically similar, TGCT-D, TGCT-L and PVNS differ in their clinical and biologic behavior and should not be used as synonyms. 2,8,14 TGCT-L may occur at any age but is most often seen in the third to fifth decades with a slight female predominance, unlike the younger age group, which is affected in TGCT-D and PVNS.…”

Section: Discussionmentioning

confidence: 99%

Localized Tenosynovial Giant Cell Tumor of Tendon Sheath

et al. 2000

View full text Add to dashboard Cite

“…Only 37 malignant tenosynovial GCTs have been reported in the literature since 1979, and these are summarized in ►Tables 1-3. [3][4][5][6][7][8][9][10][11][12][13][14][15][16][17] Of these 37 patients, follow-up outcome was known in 30 patients; one patient had died of other causes (DOC). Of the remaining 29 patients, 11 patients died of disease (DOD), 4 patients were living with disease (LWD) and 14 patients had no evidence of disease (NED) since their last treatment, with a follow-up of 6 months to 49 years.…”

Section: Discussionmentioning

confidence: 99%

Malignant Giant Cell Tumor in the Carpal Tunnel: A Case Report and Review of Literature

et al. 2013

View full text Add to dashboard Cite

Giant cell tumors (GCTs) of the soft tissues are, based on their site of origin, divided into nontenosynovial and tenosynovial. Nontenosynovial GCTs are less common, and their biological behavior varies from borderline malignant to full-blown malignant. Tenosynovial GCTs, also known as GCTs of the tendon sheath or pigmented villonodular synovitis are nearly always benign, with a strong capacity for local recurrence because of their pattern of growth. 1,2 We present a case of malignant tenosynovial GCT in the carpal tunnel and a review of the literature. Case ReportA 66-year-old man, with tingling and a loss of sensation in the left hand, was treated in our center for a ganglion cyst in the carpal tunnel of the left hand (►Fig. 1). This ganglion was Keywords ► malignant giant cell ► carpal tunnel syndrome AbstractBackground Malignant tenosynovial giant cell tumors (GCTs) are extremely rare, and their etiology is unknown. However, this type of malignancy is associated with high metastasis and mortality rates. Therefore, the treatment of choice is wide excision. Case Description A 66-year-old man complained of tingling and loss of sensation in the left hand, caused by a tumor that compressed the median nerve. The tumor was excised. Histopathologic examination revealed a ganglion cyst. Two years later, the patient visited our clinic with recurrent and similar complaints of the left hand. This time, however, the lesion turned out to be a malignant tenosynovial GCT and was treated by amputation of the forearm. Literature Review Since 1979, only 37 malignant tenosynovial GCTs have been reported in literature. Follow-up of these patients showed that 11 patients died of the disease, 4 patients were still living with the disease, and 14 patients had no evidence of disease after treatment. The other seven patients were lost to follow-up, and one patient died of other causes. In these 37 patients, a high incidence of lymph node metastasis (41%) and a high mortality rate (30%) were seen. Clinical Relevance Although this malignant tenosynovial GCT is very rare, high mortality rates have been observed because of the high incidence of lymph node metastases. Therefore, more awareness has to be created, to recognize and treat this tumor timely.

show abstract

Malignant giant cell tumor of synovium and locally destructive pigmented villonodular synovitis: Ultrastructural and immunohistochemical study and review of the literature

Cited by 68 publications

References 22 publications

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Pigmented Villonodular Synovitis: Radiologic-Pathologic Correlation

Localized Tenosynovial Giant Cell Tumor of Tendon Sheath

Malignant Giant Cell Tumor in the Carpal Tunnel: A Case Report and Review of Literature

Contact Info

Product

Resources

About