Malignant germ cell tumors of the ovary

Bakri, Younes N.; Ezzat, Adnan; Akhtar, M. A.; Dohami, Hessa Al; Zahrani, Ahlam Al

doi:10.1016/s0301-2115(99)00213-4

Cited by 53 publications

(38 citation statements)

References 21 publications

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“…Over the last few decades, fertility-sparing surgery has been the standard management of patients desiring fertility preservation, regardless of disease stage. Conservative surgery was not shown to affect the survival figures (10,23,24). OYSTs are characterized by a high malignant potential, but are also highly chemosensitive.…”

Section: Discussionmentioning

confidence: 90%

Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis

Guo¹,

Zhang²,

Zhu³

2014

Molecular and Clinical Oncology

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Abstract. This study was conducted to determine the prognostic value of serum α-fetoprotein (AFP) levels in patients with ovarian yolk sac tumor (OYST). We performed a systematic review and meta-analysis to assess the associations between serum AFP level and prognosis in OYST. A total of 12 quantitative studies met the inclusion criteria. Preoperative AFP was not found to be associated with overall survival (OS) [odds ratio (OR)= 0.84, 95% confidence interval (CI): 0.43-1.62] in OYST. However, a high postoperative AFP level was associated with worse OS (OR=0.16, 95% CI: 0.05-0.48) and relapse-free survival (RFS) (OR=0.18, 95% CI: 0.08-0.43) compared to a low postoperative AFP level in patients with OYST. In addition, a postoperative AFP level of >1,000 ng̸ml was associated with a decrease in OS (OR= 0.16, 95% CI: 0.05-0.50) and RFS (OR=0.21, 95% CI: 0.08-0.57). In conclusion, the postoperative, but not the preoperative, AFP level was found to be a prognostic factor in patients with OYST. In particular, a postoperative AFP level of >1,000 ng/ml was an indicator of poor prognosis in patients with OYST.

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Section: Discussionmentioning

confidence: 90%

Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis

Guo¹,

Zhang²,

Zhu³

2014

Molecular and Clinical Oncology

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“…Clinicopathologic features and therapeutic approaches for the pregnant pure immature teratoma cases were summarized in Table 1 Prognosis for immature teratomas has improved due to the routine use of imaging during pregnancy and because of chemotherapy. Most ovarian cancers associated with pregnancy were detected by ultrasonography (USG) (12). For immature ovarian teratomas during pregnancy; the main presenting symptom was adnexal mass (eight cases) followed by abdominal or pelvic pain (four cases).…”

Section: Discussionmentioning

confidence: 99%

Ovarian Immature Teratoma Detected During Pregnancy

Hasdemir¹,

Güvenal²,

Menekşe³

et al. 2015

Med Sci and Discov

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“…Treatment of malignant germ cell tumors of the ovary during pregnancy should be guided by the time and drug dependent of maternal and fetal prognosis during therapy. 6 Adverse fetal effects of using bleomycin, etopocide and cisplatin have been reported in two cases. One child exposed to this regimen was born at 28 weeks of gestation with ventriculomegaly secondary to cerebral atrophy.…”

Section: Discussionmentioning

confidence: 99%

A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

2009

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Ovarian cancer rarely complicates pregnancy. Usually these malignancies consist of germ cell tumors. Preserving maternal safety along with favorable neonatal outcome is a subject of debate in the management of ovarian cancer during pregnancy. In this report, the authors describe a 25-year-old primigravid woman who was diagnosed to with an ovarian immature teratoma which was diagnosed at 13th weeks of pregnancy during a routine sonography. She underwent oophorectomy at week 21 of her gestation. Then she received three cycles of BEP regimen (bleomycin, etoposide, and cisplatin) during her pregnancy until week 37 of gestation. At 36 weeks she delivered a male baby with mild glandular hypospadia who was otherwise normal. Management of immature teratoma after the first trimester of pregnancy is similar to non-pregnant patients and is safe for both the mother and the fetus.

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Malignant germ cell tumors of the ovary

Cited by 53 publications

References 21 publications

Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis

Prognostic value of serum α-fetoprotein in ovarian yolk sac tumors: A systematic review and meta-analysis

Ovarian Immature Teratoma Detected During Pregnancy

A favorable maternal and neonatal outcome following chemotherapy with etoposide, bleomycin, and cisplatin for management of grade 3 immature teratoma of the ovary

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