Malignant Germ Cell Tumors of the Ovary

Tewari, Krishnansu S.; Cappuccini, Fabio; DiSaia, Philip J.; Berman, Michael L.; Manetta, Alberto; Kohler, Matthew F.

doi:10.1097/00006250-200001000-00024

Cited by 59 publications

(82 citation statements)

References 20 publications

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“…Fever is present in 10-25% of the cases. Ascites or peritonitis secondary to torsion, infection, or rupture of the ovarian tumor, is other possible clinical features [6].…”

Section: Resultsmentioning

confidence: 99%

Ovarian Germ Cell Tumours: Clinicopathological Features and Treatment Outcomes

Naqos¹,

Taleb²,

Bouchbika³

et al. 2016

IOSR

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“…Fever is present in 10-25% of the cases. Ascites or peritonitis secondary to torsion, infection, or rupture of the ovarian tumor, is other possible clinical features [6].…”

Section: Resultsmentioning

confidence: 99%

Ovarian Germ Cell Tumours: Clinicopathological Features and Treatment Outcomes

Naqos¹,

Taleb²,

Bouchbika³

et al. 2016

IOSR

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“…The mature type or benign is formed of well-differentiated tissue, the immature is derived from somatic embryo cell differentiation, whereas the malignant is characterized by the presence of one or more components malignant germ cell tumors (ISAACS, 1985;TEWARI, 2000). Hence in the present case the histopathological analysis showed adnexal structures of the skin: like hair, sebaceous gland, apocrine areas with cartilaginous tissue (Figures 3 and 4), and most cysts were lined by stratified squamous epithelium, histological features that allow the diagnosis of mature teratoma ( VALE et al 1984;LEFEBVRE et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

Uma Rara Ocorrência De Teratoma Bilateral Em Búfala – Descrição De Um Caso

Vale¹

2015

AVS

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RESUMO:O caso se refere a um estudo que avaliou n = 615 trato genital de fêmeas de búfalos abatidos num matadouro na cidade de Belém, Estado do Pará, Brasil, onde um caso de teratoma ovariano bilateral foi encontrado o que correspondeu a 0,16% de ocorrência de patologias totais. O teratoma é um tumor de células germinativas de ocorrência frequente em animais domésticos, porém raro em bubalinos. Macroscopicamente, o tumor de ovário bilateral mostrou duas estruturas medindo 10 x 10 x 10 cm e 9 x 9 x 9 cm para a gonada direita e para a esquerda, respectivamente. Ambos mostraram uma superfície multilobulada de consistência firme que, ao corte mostrou cistos macro no interior do estroma ovários, o qual continha material estranho como cabelo e material de consistência pastosa acinzentada. Na análise histopatológica observou-se a presença de um tecido epitelial escamoso estratificado, glândulas sebáceas e cartilagens, como estruturas representativas do tumor, confirmando o diagnóstico de teratoma em ambos ovários.Palavras-chave: Amazônia, búfalo, neoplasia ovariana, teratoma, tumor OCORRÊNCIA BILATERAL DE TERATOMA OVARIANO EM BÚFALA; DESCRIÇÃO DE UM CASO ABSTRACT:The case is referring to a study that evaluated n=615 genital tracts of female buffaloes slaughtered in an abattoir in Belem city, Para state, Brazil, where one case of bilateral ovarian teratoma was found which corresponded to 0.16% of total pathologies observed. The teratoma is a germ cell tumor of infrequent occurrence in domestic animals. Macroscopically, the bilateral ovarian tumor showed two structures measuring 10 x 10 x 10 cm and 9 x 9 x 9 cm to the right and left, respectively. Both showed a multilobulated surface of firm consistency that when cutting showed macro cysts inside the ovaries stroma, which contained hair and grayish pasty material. In the histopathological analysis it was observed a stratified squamous epithelial tissue, sebaceous glands and cartilage, as representative structures of the tumor, confirming the diagnosis of ovarian teratoma.

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“…Dysgerminomas on the other hand constitute a group of slower growing tumors, which can present with nonspecific abdominal symptoms. Less common signs include abdominal distension, fever, ascites and vaginal bleeding [1,3,42,43]. Staging is according to the FIGO system, as for epithelial ovarian cancers.…”

Section: Discussionmentioning

confidence: 99%

Systemic management of malignant ovarian germ cell tumors in older women: two case reports and a review of the literature

Luís

Boussios

Dumas

et al. 2016

CBN

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Background Ovarian germ cell tumors (OGCT) account for 2-5% of ovarian malignancies, with an annual incidence of 0.5-1:100,000, typically occurring in young women. Yolk sac tumor (YST) is the second most common type of OGCT and has an aggressive phenotype. The rarity of this pathology in postmenopausal women poses challenges in the diagnosis and treatment. Patients and Methods We report two clinical cases of YST in postmenopausal women treated at the Royal Marsden and discuss diagnosis and treatment issues of OGCTs in older women. A literature review was also performed, which identified thirty-nine cases, including the two reported in this article. Results and ConclusionThis showed that YSTs in older women are rare and are generally aggressive with poor clinical outcomes. Twelve of the described patients with malignant OGCTs died within 8 months of diagnosis.In conclusion, YST in postmenopausal women can have an aggressive disease course compared with younger patients. More evidence for the tolerability and outcomes of cytoreductive surgical approaches and intensive chemotherapy regimens in older patients is required.

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Malignant Germ Cell Tumors of the Ovary

Cited by 59 publications

References 20 publications

Ovarian Germ Cell Tumours: Clinicopathological Features and Treatment Outcomes

Ovarian Germ Cell Tumours: Clinicopathological Features and Treatment Outcomes

Uma Rara Ocorrência De Teratoma Bilateral Em Búfala – Descrição De Um Caso

Systemic management of malignant ovarian germ cell tumors in older women: two case reports and a review of the literature

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