Malignant germ cell tumors in men aged 50 years and over are associated with adverse pathologic features and higher stage at presentation

Giant testicular mixed germ cell tumour in an elderly patient: A case report

“…The retrospective study by Fawaz Almutairi et al 10 provides valuable insights into malignant germ cell tumours (GCTs) in men aged 50 years and older, a population often overlooked in medical research. Covering the period from 2005 to 2021, the study shows a decline in GCT incidence after the age of 65, shedding light on age-specific patterns of tumour occurrence.…”

“… 11 Mixed GCTs, when present, often include embryonal carcinoma, seminoma and yolk sac tumour, with embryonal carcinoma being the most common component at 77 %. 10 12 In addition, a significant proportion of patients in this age group present with aggressive pathological features such as lymphovascular invasion, retroperitoneal/lymph node involvement and higher stage, accounting for 77 % of cases. Clinical follow-up data show that 14 % of patients aged 50 years and older die of disease-related causes.…”

“…Clinical follow-up data show that 14 % of patients aged 50 years and older die of disease-related causes. 10 …”

“…When compared to their younger counterparts, malignant GCTs in men aged 50 years and older tend to be larger, higher stage, more frequent vascular and rete testis invasion, and less associated with intratubular germ cell neoplasia, which is present in only 47 % of cases. 10 Here, testicular cancer was diagnosed with a size of 17 × 16 cm. Lack of knowledge and awareness unnecessarily delays consultation at an early stage.…”