Malignant Fibrous Histiocytoma of the Chest Wall Masquerading as Medullary Breast Carcinoma

Sharma, Prashant; Jain, Shyama; Nigam, Sonu; Bahadur, Anil Kumar; Ouseph, Madhu M.

doi:10.1159/000326020

Cited by 5 publications

(3 citation statements)

References 7 publications

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“…However, clinical history, physical findings, or any histologic pattern is not specific of this tumor. We found many osteoclast-like giant cells also reported by Balbi et al in literature, and it can lead to diagnostic difficulty mimicking malignant fibrous histiocytoma [ 10 , 11 ]. Microscopically, it is impossible to differentiate as it mimics many of the malignant epithelial and mesenchymal tumors.…”

Section: Case Presentationsupporting

confidence: 77%

Primary undifferentiated pleomorphic sarcoma of the breast in a young female: a case report

et al. 2016

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BackgroundUndifferentiated pleomorphic sarcoma is a rare entity and requires extensive immunohistochemical markers to differentiate it from other tumors of the breast.Case presentationWe present a 29-year-old female with a left breast lump for 2 months. Initial diagnosis of malignant spindle cell tumor was done on core biopsy following which total mastectomy was done. After extensive sampling, on histology, highly pleomorphic spindle cells palisading the area of geographic necrosis with very high atypical mitosis were seen. As there was diagnostic difficulty, immunohistochemical antibody panel was used and diagnosis of undifferentiated pleomorphic sarcoma of the breast was made by exclusion.ConclusionsCore biopsy with immunostaining is possibly superior to FNA as an initial diagnostic modality for breast masses with atypical features.

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Section: Case Presentationsupporting

confidence: 77%

Primary undifferentiated pleomorphic sarcoma of the breast in a young female: a case report

et al. 2016

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“…[3][4][5] In these patients, CT chest/abdomen, mammography and FDG-PET are useful to pin-point the primary site but further extensive evaluation is inappropriate in the absence of specific symptoms or any indications from the brain biopsy, whether open or stereotactic. [6] Histopathology of the brain metastasis, though nearly always difficult to obtain, provides valuable clues in indicating a likely organ of origin. Immunohistochemical staining demonstrating antigen(s) specific for the tissue, organ or neoplasm of origin can be the clinching supplementary investigation.…”

Section: Commentarymentioning

confidence: 99%

“…Still, few cases become very difficult to interpret. Sharma et al, [6] reported a case of MFH of chest wall which on FNAC was reported as medullary carcinoma of breast in two separate institutions.…”

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confidence: 99%