Malignant fibrous histiocytoma of the mandible

Abstract

We report a case of malignant fibrous histiocytoma (MFH) primary within the mandible of a 32-year-old female. The mandible is a rare location of MFH, accounting for only 3% of all tumours of this type occurring within bone. The clinical, pathological and radiographic features are discussed with special emphasis on the radiographic features of this lesion.

Malignant Fibrous Histiocytoma of the Head and Neck: CT and MR Imaging Findings

“…2,17 Histopathologically, MFH can be divided into the following 4 morphologic subtypes in decreasing order, depending on the predominant cellular components: storiform-pleomorphic (50%-60%), myxoid (25%), giant cell (5%-10%), and inflammatory (Ͻ 5%), some of which have prognostic significance. 2,3,12,18 The myxoid variant has better prognosis compared with the storiform-pleomorphic type. It is not unusual for several morphologic patterns to be observed within 1 lesion.…”

“…It is not unusual for several morphologic patterns to be observed within 1 lesion. 12 Clinically, patients with MFH usually present with an enlarging, painless, solid soft-tissue mass, most frequently in the lower extremity followed by the upper extremity and the retroperitoneum. 2,3 Most patients are between 50 and 70 years of age, and men are affected 2-3 times as commonly as women.…”

“…2,7 Despite this ubiquity, however, MFH remains relatively uncommon in the head and neck region, accounting for 3%-10% of all cases. 8,9 To our knowledge, except in a limited number of case reports, [10][11][12][13] most of the previous reports on MFH of the head and neck focused on the clinicopathologic features, 8,9,[14][15][16] and the imaging features were not the major concern. The purpose of this study was to investigate the CT and MR imaging features of 13 cases of MFH arising in various locations of the head and neck.…”

Malignant Fibrous Histiocytoma of Maxilla

“…8 A history of antecedent trauma has been reported in about 20% of the cases suggesting that some of these tumors may represent an initial proliferative response to trauma. 6 So, trauma may be the etiologic factor in this case.…”

“…The etiology of this tumor is unknown but seems to be multifactorial. Genetic background, environmental factors such as trauma, 6 radiotherapy 1,7 and malignant transformation from benign lesions has been suggested to be involved in the etiology of this tumor.…”