Malignant fibrous histiocytoma of the head and neck: a case series

Hardison, Scott A.; Davis, Paul; Browne, J. Dale

doi:10.1016/j.amjoto.2012.06.010

Cited by 11 publications

(13 citation statements)

References 12 publications

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“…UPS commonly manifests as diffuse, ill-defined, painful swellings that typically affect the mandible and cause extensive bone destruction that is associated with irregular radiolucent uni-or multilocular images and may also be associated with floating teeth depending on tumor size 18,19 . The neoplasm may also cause pathological fractures 14 , as demonstrated in our case.…”

Section: Discussionsupporting

confidence: 70%

“…UPS is a very aggressive neoplasm that predominantly affects the upper and lower extremities and the retroperitoneum; only 10% of cases are diagnosed in the head and neck area and account for less than 0.5% of all malignant neoplasms located in this region 3,14 . The etiology of UPS is largely unknown, but some cases are thought to originate following radiation therapy 3,15 .…”

Section: Discussionmentioning

confidence: 99%

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Undifferentiated pleomorphic sarcoma of the mandible

Benites

Miranda-Silva

Fonseca

et al. 2020

JKAOMS

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Undifferentiated pleomorphic sarcoma (UPS) is a high-grade neoplasm that is usually located in the extremities and retroperitoneum. In the past, UPS was considered the most common soft tissue sarcoma in adults; due to improvements in diagnostic techniques, most cases have been reclassified as other lineage-specific tumors. Gnathic bones are rarely affected, and the clinicopathological characteristics of this neoplasm when diagnosed in the jaw remain to be better described. In this report, we present a rare case of mandibular UPS affecting an 88-year-old female who demonstrated a painful swelling on the right side of the mandible that was accompanied by a pathological fracture. Microscopic examination revealed a pleomorphic spindlecell neoplasm with mitotic figures and necrosis. The patient underwent surgery and adjuvant radiotherapy but experienced metastasis after 12 months of follow-up and died. Diagnosis of UPS is challenging, and oral pathologists must be aware of this entity when dealing with aggressive undifferentiated neoplasms.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 99%

Undifferentiated pleomorphic sarcoma of the mandible

Benites

Miranda-Silva

Fonseca

et al. 2020

JKAOMS

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“…MFH is reported to be one of the most common soft tissue sarcomas in adults; the majority of MFHs are high-grade lesions and frequently recur locally. Surgery is considered the primary treatment for MFH in the head and neck region, although the addition of chemotherapy and radiotherapy appears to be helpful for certain patients (14,15). Lymphatic metastases are also rare, ranging between 0 and 15% (11).…”

Section: Discussionmentioning

confidence: 99%

Computed tomography and magnetic resonance imaging findings of malignant fibrous histiocytoma of the head and neck

Geng

Xiaofei

et al. 2016

Molecular and Clinical Oncology

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Abstract. The aim of this study was to analyze the imaging findings of 15 cases of malignant fibrous histiocytoma (MFH) of the head and neck, in order to better understand the tumor characteristics based on computed tomography (CT) and magnetic resonance imaging (MRI). CT (n=11) and MRI (n=4) images from 15 patients with histologically diagnosed MFH of the head and neck were retrospectively analyzed. The imaging characteristics were analyzed and compared among different histological subtypes. The lesions were primarily located in the maxillary sinus in 5 patients, the ethmoid sinus in 1 patient, the infratemporal fossa in 2 patients, the neck in 4 patients, the left mandible in 1 patient, the gingiva in 1 patient and the epiglottis in 1 patient. A total of 4 cases were associated with radiotherapy. All the lesions were ill-defined, ranging in size from 2.1 to 5.1 cm in the largest diameter. Bone fractures were evident in 9 cases. The attenuation, signal and enhancement patterns varied, although inflammatory MFH exhibited prolonged enhancement in dual-phase enhanced CT scans. MFH of the head and neck is rare but may be associated with radiotherapy. Although the imaging manifestations of MFH are various and non-specific, inflammatory MFH exhibits prolonged enhancement on dual-phase enhanced CT scans.

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“…FH can be benign or malignant, and malignant FH is usually found in the lower extremities, upper extremities, and retroperitoneum, in order of frequency. Malignant FH in the head and neck area accounts for less than 10% of all malignant FH, and less than 0.5% of all malignant head and neck tumors 3 4 . The treatment of choice for malignant FH is surgical excision, and obtaining a clear surgical margin is crucial due to its survival benefit 2 3 5 .…”

Section: Introductionmentioning

confidence: 99%

Deep benign fibrous histiocytoma in the oral cavity: a case report

Cho

Kim

et al. 2015

J Korean Assoc Oral Maxillofac Surg

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Benign fibrous histiocytoma (FH) is a benign tumor composed of fibroblasts and histiocytes in varying proportions. This tumor is usually found in adult extremities but rarely occurs in deep soft tissues of the oral cavity. As it is difficult to diagnose with physical and radiologic exams, deep benign FH can only be diagnosed by histopathology. We report a case of a 36-year-old female patient who came to our department with painless swelling in the right buccal mucosa. This case report reviews the clinical, radiological, and histological aspects of this tumor.

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Malignant fibrous histiocytoma of the head and neck: a case series

Cited by 11 publications

References 12 publications

Undifferentiated pleomorphic sarcoma of the mandible

Undifferentiated pleomorphic sarcoma of the mandible

Computed tomography and magnetic resonance imaging findings of malignant fibrous histiocytoma of the head and neck

Deep benign fibrous histiocytoma in the oral cavity: a case report

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